Impact of a 4th Generation Iterative Reconstruction Technique on Image Quality in Low-Dose Computed Tomography of the Chest in Immunocompromised Patients.
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Impact of a 4th Generation Iterative Reconstruction Technique on Image Quality in Low-Dose Computed Tomography of the Chest in Immunocompromised Patients. / Laqmani, A; Buhk, J H; Henes, F O; Klink, T; Sehner, S; von Schultzendorff, H C; Hammerle, D; Nagel, H D; Adam, G; Regier, M.
In: ROFO-FORTSCHR RONTG, Vol. 185, No. 8, 8, 2013, p. 749-757.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of a 4th Generation Iterative Reconstruction Technique on Image Quality in Low-Dose Computed Tomography of the Chest in Immunocompromised Patients.
AU - Laqmani, A
AU - Buhk, J H
AU - Henes, F O
AU - Klink, T
AU - Sehner, S
AU - von Schultzendorff, H C
AU - Hammerle, D
AU - Nagel, H D
AU - Adam, G
AU - Regier, M
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2013
Y1 - 2013
N2 - PURPOSE: To determine the image quality of an iterative reconstruction (IR) technique in low-dose MDCT (LDCT) of the chest of immunocompromised patients in an intraindividual comparison to filtered back projection (FBP) and to evaluate the dose reduction capability.MATERIALS AND METHODS: 30 chest LDCT scans were performed in immunocompromised patients (Brilliance iCT; 20-40 mAs; mean CTDIvol: 1.7 mGy). The raw data were reconstructed using FBP and the IR technique (iDose4™, Philips, Best, The Netherlands) set to seven iteration levels. 30 routine-dose MDCT (RDCT) reconstructed with FBP served as controls (mean exposure: 116 mAs; mean CDTIvol: 7.6 mGy). Three blinded radiologists scored subjective image quality and lesion conspicuity. Quantitative parameters including CT attenuation and objective image noise (OIN) were determined.RESULTS: In LDCT high iDose4™ levels lead to a significant decrease in OIN (FBP vs. iDose7: subscapular muscle 139.4 vs. 40.6 HU). The high iDose4™ levels provided significant improvements in image quality and artifact and noise reduction compared to LDCT FBP images. The conspicuity of subtle lesions was limited in LDCT FBP images. It significantly improved with high iDose4™ levels (> iDose4). LDCT with iDose4™ level 6 was determined to be of equivalent image quality as RDCT with FBP.CONCLUSION: iDose4™ substantially improves image quality and lesion conspicuity and reduces noise in low-dose chest CT. Compared to RDCT, high iDose4™ levels provide equivalent image quality in LDCT, hence suggesting a potential dose reduction of almost 80%.
AB - PURPOSE: To determine the image quality of an iterative reconstruction (IR) technique in low-dose MDCT (LDCT) of the chest of immunocompromised patients in an intraindividual comparison to filtered back projection (FBP) and to evaluate the dose reduction capability.MATERIALS AND METHODS: 30 chest LDCT scans were performed in immunocompromised patients (Brilliance iCT; 20-40 mAs; mean CTDIvol: 1.7 mGy). The raw data were reconstructed using FBP and the IR technique (iDose4™, Philips, Best, The Netherlands) set to seven iteration levels. 30 routine-dose MDCT (RDCT) reconstructed with FBP served as controls (mean exposure: 116 mAs; mean CDTIvol: 7.6 mGy). Three blinded radiologists scored subjective image quality and lesion conspicuity. Quantitative parameters including CT attenuation and objective image noise (OIN) were determined.RESULTS: In LDCT high iDose4™ levels lead to a significant decrease in OIN (FBP vs. iDose7: subscapular muscle 139.4 vs. 40.6 HU). The high iDose4™ levels provided significant improvements in image quality and artifact and noise reduction compared to LDCT FBP images. The conspicuity of subtle lesions was limited in LDCT FBP images. It significantly improved with high iDose4™ levels (> iDose4). LDCT with iDose4™ level 6 was determined to be of equivalent image quality as RDCT with FBP.CONCLUSION: iDose4™ substantially improves image quality and lesion conspicuity and reduces noise in low-dose chest CT. Compared to RDCT, high iDose4™ levels provide equivalent image quality in LDCT, hence suggesting a potential dose reduction of almost 80%.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Algorithms
KW - Anthropometry
KW - Artifacts
KW - Female
KW - Humans
KW - Image Enhancement
KW - Image Processing, Computer-Assisted
KW - Male
KW - Middle Aged
KW - Multidetector Computed Tomography
KW - Observer Variation
KW - Opportunistic Infections
KW - Pneumonia
KW - Radiation Dosage
KW - Young Adult
U2 - 10.1055/s-0033-1335577
DO - 10.1055/s-0033-1335577
M3 - SCORING: Journal article
C2 - 23749649
VL - 185
SP - 749
EP - 757
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 8
M1 - 8
ER -
