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Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays

Standard

Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays. / Röser, K; Jäkel, K T; Herbst, H; Löning, T.

In: PATHOLOGE, Vol. 26, No. 5, 09.2005, p. 345-52.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Röser, K, Jäkel, KT, Herbst, H & Löning, T 2005, 'Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays', PATHOLOGE, vol. 26, no. 5, pp. 345-52. https://doi.org/10.1007/s00292-005-0777-y

APA

Röser, K., Jäkel, K. T., Herbst, H., & Löning, T. (2005). Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays. PATHOLOGE, 26(5), 345-52. https://doi.org/10.1007/s00292-005-0777-y

Vancouver

Röser K, Jäkel KT, Herbst H, Löning T. Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays. PATHOLOGE. 2005 Sep;26(5):345-52. https://doi.org/10.1007/s00292-005-0777-y

Bibtex

@article{fc0032dacfa24c75bb0b8032550165ab,
title = "Immunph{\"a}notypische Charakterisierung von Speicheldr{\"u}sentumoren unter Verwendung von Gewebe-Micro-Arrays",
abstract = "Systematic analysis of gene expression in salivary gland tumors is necessary to identify genes associated with specific tumor types. From the salivary gland register of the University Hospital Hamburg-Eppendorf sufficient samples of various tumors were available to generate Tissue Micro-Arrays (TMA). In light of the considerable heterogeneity of salivary gland tumors, this study was aimed at evaluating the suitability of TMA in salivary gland diagnostics and research. Epithelial antigens are not sufficient for a tumor-type-specific characterization. Myoepithelial markers are suitable for distinguishing biphasic tumor types from purely epithelial tumors. The detection of amylase in acinic cell carcinomas, and the detection of steroid hormone receptors in these and other malignant salivary gland tumors particularly in combination with the expression of transcription factors, oncogenes and proliferation associated antigens result in characteristic expression profiles. These may prove to be valuable for further investigations, especially on the molecular level.",
keywords = "Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Myoepithelioma, Oligonucleotide Array Sequence Analysis, Receptors, Steroid, Salivary Gland Neoplasms, Transcription Factors, English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "K R{\"o}ser and J{\"a}kel, {K T} and H Herbst and T L{\"o}ning",
year = "2005",
month = sep,
doi = "10.1007/s00292-005-0777-y",
language = "Deutsch",
volume = "26",
pages = "345--52",
journal = "PATHOLOGE",
issn = "0172-8113",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Immunphänotypische Charakterisierung von Speicheldrüsentumoren unter Verwendung von Gewebe-Micro-Arrays

AU - Röser, K

AU - Jäkel, K T

AU - Herbst, H

AU - Löning, T

PY - 2005/9

Y1 - 2005/9

N2 - Systematic analysis of gene expression in salivary gland tumors is necessary to identify genes associated with specific tumor types. From the salivary gland register of the University Hospital Hamburg-Eppendorf sufficient samples of various tumors were available to generate Tissue Micro-Arrays (TMA). In light of the considerable heterogeneity of salivary gland tumors, this study was aimed at evaluating the suitability of TMA in salivary gland diagnostics and research. Epithelial antigens are not sufficient for a tumor-type-specific characterization. Myoepithelial markers are suitable for distinguishing biphasic tumor types from purely epithelial tumors. The detection of amylase in acinic cell carcinomas, and the detection of steroid hormone receptors in these and other malignant salivary gland tumors particularly in combination with the expression of transcription factors, oncogenes and proliferation associated antigens result in characteristic expression profiles. These may prove to be valuable for further investigations, especially on the molecular level.

AB - Systematic analysis of gene expression in salivary gland tumors is necessary to identify genes associated with specific tumor types. From the salivary gland register of the University Hospital Hamburg-Eppendorf sufficient samples of various tumors were available to generate Tissue Micro-Arrays (TMA). In light of the considerable heterogeneity of salivary gland tumors, this study was aimed at evaluating the suitability of TMA in salivary gland diagnostics and research. Epithelial antigens are not sufficient for a tumor-type-specific characterization. Myoepithelial markers are suitable for distinguishing biphasic tumor types from purely epithelial tumors. The detection of amylase in acinic cell carcinomas, and the detection of steroid hormone receptors in these and other malignant salivary gland tumors particularly in combination with the expression of transcription factors, oncogenes and proliferation associated antigens result in characteristic expression profiles. These may prove to be valuable for further investigations, especially on the molecular level.

KW - Biomarkers, Tumor

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - Myoepithelioma

KW - Oligonucleotide Array Sequence Analysis

KW - Receptors, Steroid

KW - Salivary Gland Neoplasms

KW - Transcription Factors

KW - English Abstract

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00292-005-0777-y

DO - 10.1007/s00292-005-0777-y

M3 - SCORING: Zeitschriftenaufsatz

C2 - 16049672

VL - 26

SP - 345

EP - 352

JO - PATHOLOGE

JF - PATHOLOGE

SN - 0172-8113

IS - 5

ER -