Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma
Standard
Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma. / Bisht, Kamlesh; Fukao, Taro; Chiron, Marielle; Richardson, Paul; Atanackovic, Djordje; Chini, Eduardo; Chng, Wee Joo; Van De Velde, Helgi; Malavasi, Fabio.
In: CANCER MED-US, Vol. 12, No. 20, 15.10.2023, p. 20332-20352.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma
AU - Bisht, Kamlesh
AU - Fukao, Taro
AU - Chiron, Marielle
AU - Richardson, Paul
AU - Atanackovic, Djordje
AU - Chini, Eduardo
AU - Chng, Wee Joo
AU - Van De Velde, Helgi
AU - Malavasi, Fabio
N1 - © 2023 Sanofi and The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2023/10/15
Y1 - 2023/10/15
N2 - BACKGROUND: CD38 has been established as an important therapeutic target for multiple myeloma (MM), for which two CD38 antibodies are currently approved-daratumumab and isatuximab. CD38 is an ectoenzyme that degrades NAD and its precursors and is involved in the production of adenosine and other metabolites.AIM: Among the various mechanisms by which CD38 antibodies can induce MM cell death is immunomodulation, including multiple pathways for CD38-mediated T-cell activation. Patients who respond to anti-CD38 targeting treatment experience more marked changes in T-cell expansion, activity, and clonality than nonresponders.IMPLICATIONS: Resistance mechanisms that undermine the immunomodulatory effects of CD38-targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune microenvironment-related, such as changes to the natural killer (NK) cell numbers and function in the bone marrow niche. There are numerous strategies to overcome this resistance, which include identifying and targeting other therapeutic targets involved in, for example, adenosine production, the activation of NK cells or monocytes through immunomodulatory drugs and their combination with elotuzumab, or with bispecific T-cell engagers.
AB - BACKGROUND: CD38 has been established as an important therapeutic target for multiple myeloma (MM), for which two CD38 antibodies are currently approved-daratumumab and isatuximab. CD38 is an ectoenzyme that degrades NAD and its precursors and is involved in the production of adenosine and other metabolites.AIM: Among the various mechanisms by which CD38 antibodies can induce MM cell death is immunomodulation, including multiple pathways for CD38-mediated T-cell activation. Patients who respond to anti-CD38 targeting treatment experience more marked changes in T-cell expansion, activity, and clonality than nonresponders.IMPLICATIONS: Resistance mechanisms that undermine the immunomodulatory effects of CD38-targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune microenvironment-related, such as changes to the natural killer (NK) cell numbers and function in the bone marrow niche. There are numerous strategies to overcome this resistance, which include identifying and targeting other therapeutic targets involved in, for example, adenosine production, the activation of NK cells or monocytes through immunomodulatory drugs and their combination with elotuzumab, or with bispecific T-cell engagers.
U2 - 10.1002/cam4.6619
DO - 10.1002/cam4.6619
M3 - SCORING: Review article
C2 - 37840445
VL - 12
SP - 20332
EP - 20352
JO - CANCER MED-US
JF - CANCER MED-US
SN - 2045-7634
IS - 20
ER -
