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Immunological implications of pregnancy-induced microchimerism

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Immunological implications of pregnancy-induced microchimerism. / Kinder, Jeremy M; Stelzer, Ina A; Arck, Petra C; Way, Sing Sing.

In: NAT REV IMMUNOL, Vol. 17, No. 8, 08.2017, p. 483-494.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kinder, JM, Stelzer, IA, Arck, PC & Way, SS 2017, 'Immunological implications of pregnancy-induced microchimerism', NAT REV IMMUNOL, vol. 17, no. 8, pp. 483-494. https://doi.org/10.1038/nri.2017.38

APA

Kinder, J. M., Stelzer, I. A., Arck, P. C., & Way, S. S. (2017). Immunological implications of pregnancy-induced microchimerism. NAT REV IMMUNOL, 17(8), 483-494. https://doi.org/10.1038/nri.2017.38

Vancouver

Kinder JM, Stelzer IA, Arck PC, Way SS. Immunological implications of pregnancy-induced microchimerism. NAT REV IMMUNOL. 2017 Aug;17(8):483-494. https://doi.org/10.1038/nri.2017.38

Bibtex

@article{981545d23b3841f583613d8616d6d405,
title = "Immunological implications of pregnancy-induced microchimerism",
abstract = "Immunological identity is traditionally defined by genetically encoded antigens, with equal maternal and paternal contributions as a result of Mendelian inheritance. However, vertically transferred maternal cells also persist in individuals at very low levels throughout postnatal development. Reciprocally, mothers are seeded during pregnancy with genetically foreign fetal cells that persist long after parturition. Recent findings suggest that these microchimeric cells expressing non-inherited, familially relevant antigenic traits are not accidental 'souvenirs' of pregnancy, but are purposefully retained within mothers and their offspring to promote genetic fitness by improving the outcome of future pregnancies. In this Review, we discuss the immunological implications, benefits and potential consequences of individuals being constitutively chimeric with a biologically active 'microchiome' of genetically foreign cells.",
keywords = "Journal Article, Review",
author = "Kinder, {Jeremy M} and Stelzer, {Ina A} and Arck, {Petra C} and Way, {Sing Sing}",
year = "2017",
month = aug,
doi = "10.1038/nri.2017.38",
language = "English",
volume = "17",
pages = "483--494",
journal = "NAT REV IMMUNOL",
issn = "1474-1733",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Immunological implications of pregnancy-induced microchimerism

AU - Kinder, Jeremy M

AU - Stelzer, Ina A

AU - Arck, Petra C

AU - Way, Sing Sing

PY - 2017/8

Y1 - 2017/8

N2 - Immunological identity is traditionally defined by genetically encoded antigens, with equal maternal and paternal contributions as a result of Mendelian inheritance. However, vertically transferred maternal cells also persist in individuals at very low levels throughout postnatal development. Reciprocally, mothers are seeded during pregnancy with genetically foreign fetal cells that persist long after parturition. Recent findings suggest that these microchimeric cells expressing non-inherited, familially relevant antigenic traits are not accidental 'souvenirs' of pregnancy, but are purposefully retained within mothers and their offspring to promote genetic fitness by improving the outcome of future pregnancies. In this Review, we discuss the immunological implications, benefits and potential consequences of individuals being constitutively chimeric with a biologically active 'microchiome' of genetically foreign cells.

AB - Immunological identity is traditionally defined by genetically encoded antigens, with equal maternal and paternal contributions as a result of Mendelian inheritance. However, vertically transferred maternal cells also persist in individuals at very low levels throughout postnatal development. Reciprocally, mothers are seeded during pregnancy with genetically foreign fetal cells that persist long after parturition. Recent findings suggest that these microchimeric cells expressing non-inherited, familially relevant antigenic traits are not accidental 'souvenirs' of pregnancy, but are purposefully retained within mothers and their offspring to promote genetic fitness by improving the outcome of future pregnancies. In this Review, we discuss the immunological implications, benefits and potential consequences of individuals being constitutively chimeric with a biologically active 'microchiome' of genetically foreign cells.

KW - Journal Article

KW - Review

U2 - 10.1038/nri.2017.38

DO - 10.1038/nri.2017.38

M3 - SCORING: Journal article

C2 - 28480895

VL - 17

SP - 483

EP - 494

JO - NAT REV IMMUNOL

JF - NAT REV IMMUNOL

SN - 1474-1733

IS - 8

ER -