[Immuno-isolation of xenogenic islands of Langerhans in a tissue engineered autologous cartilage capsule]
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[Immuno-isolation of xenogenic islands of Langerhans in a tissue engineered autologous cartilage capsule]. / Pollok, Jörg-Matthias; Ibarra, C; Broelsch, C E; Vacanti, J P.
In: ZBL CHIR, Vol. 123, No. 7, 7, 1998, p. 830-833.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - [Immuno-isolation of xenogenic islands of Langerhans in a tissue engineered autologous cartilage capsule]
AU - Pollok, Jörg-Matthias
AU - Ibarra, C
AU - Broelsch, C E
AU - Vacanti, J P
PY - 1998
Y1 - 1998
N2 - Islet transplantation is a potential cure for diabetes mellitus. The major problem for clinical application remains the prevention of transplant rejection without major side effects. Broad application in early disease will make the usage of xenogeneic tissue necessary. Immunoisolation is an experimental strategy to prevent rejection, by separating the transplanted allogeneic or xenogeneic cells from the host immune system using a barrier device. Current methods of immunoisolation use artificial, not completely inert materials as barrier devices and induce an unwanted foreign body reaction. Using recipient own cells for encapsulation the foreign body reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chondrocyte matrix and demonstrates the functional survival of the encapsulated islets in vivo.
AB - Islet transplantation is a potential cure for diabetes mellitus. The major problem for clinical application remains the prevention of transplant rejection without major side effects. Broad application in early disease will make the usage of xenogeneic tissue necessary. Immunoisolation is an experimental strategy to prevent rejection, by separating the transplanted allogeneic or xenogeneic cells from the host immune system using a barrier device. Current methods of immunoisolation use artificial, not completely inert materials as barrier devices and induce an unwanted foreign body reaction. Using recipient own cells for encapsulation the foreign body reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chondrocyte matrix and demonstrates the functional survival of the encapsulated islets in vivo.
M3 - SCORING: Zeitschriftenaufsatz
VL - 123
SP - 830
EP - 833
JO - ZBL CHIR
JF - ZBL CHIR
SN - 0044-409X
IS - 7
M1 - 7
ER -
