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Immune System Remodelling by Prenatal Betamethasone

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Immune System Remodelling by Prenatal Betamethasone : Effects on β-Cells and Type 1 Diabetes. / Perna-Barrull, David; Gieras, Anna; Rodriguez-Fernandez, Silvia; Tolosa, Eva; Vives-Pi, Marta.

In: FRONT ENDOCRINOL, Vol. 11, 2020, p. 540.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Perna-Barrull, D, Gieras, A, Rodriguez-Fernandez, S, Tolosa, E & Vives-Pi, M 2020, 'Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes', FRONT ENDOCRINOL, vol. 11, pp. 540. https://doi.org/10.3389/fendo.2020.00540

APA

Perna-Barrull, D., Gieras, A., Rodriguez-Fernandez, S., Tolosa, E., & Vives-Pi, M. (2020). Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes. FRONT ENDOCRINOL, 11, 540. https://doi.org/10.3389/fendo.2020.00540

Vancouver

Perna-Barrull D, Gieras A, Rodriguez-Fernandez S, Tolosa E, Vives-Pi M. Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes. FRONT ENDOCRINOL. 2020;11:540. https://doi.org/10.3389/fendo.2020.00540

Bibtex

@article{410d5500a4d34857b6a482ade8f8d25b,
title = "Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes",
abstract = "Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic β-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against β-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects β-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D.",
author = "David Perna-Barrull and Anna Gieras and Silvia Rodriguez-Fernandez and Eva Tolosa and Marta Vives-Pi",
note = "Copyright {\textcopyright} 2020 Perna-Barrull, Gieras, Rodriguez-Fernandez, Tolosa and Vives-Pi.",
year = "2020",
doi = "10.3389/fendo.2020.00540",
language = "English",
volume = "11",
pages = "540",
journal = "FRONT ENDOCRINOL",
issn = "1664-2392",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Immune System Remodelling by Prenatal Betamethasone

T2 - Effects on β-Cells and Type 1 Diabetes

AU - Perna-Barrull, David

AU - Gieras, Anna

AU - Rodriguez-Fernandez, Silvia

AU - Tolosa, Eva

AU - Vives-Pi, Marta

N1 - Copyright © 2020 Perna-Barrull, Gieras, Rodriguez-Fernandez, Tolosa and Vives-Pi.

PY - 2020

Y1 - 2020

N2 - Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic β-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against β-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects β-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D.

AB - Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic β-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against β-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects β-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D.

U2 - 10.3389/fendo.2020.00540

DO - 10.3389/fendo.2020.00540

M3 - SCORING: Review article

C2 - 32849311

VL - 11

SP - 540

JO - FRONT ENDOCRINOL

JF - FRONT ENDOCRINOL

SN - 1664-2392

ER -