Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia.
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Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia. / Müller-Schmah, Claudia; Solari, Leticia; Weis, Roland; Pfeifer, Dietmar; Scheibenbogen, Carmen; Trepel, Martin; May, Annette M; Engelhardt, Rupert; Lübbert, Michael.
In: ANN HEMATOL, Vol. 91, No. 1, 1, 2012, p. 27-32.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia.
AU - Müller-Schmah, Claudia
AU - Solari, Leticia
AU - Weis, Roland
AU - Pfeifer, Dietmar
AU - Scheibenbogen, Carmen
AU - Trepel, Martin
AU - May, Annette M
AU - Engelhardt, Rupert
AU - Lübbert, Michael
PY - 2012
Y1 - 2012
N2 - Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62-66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient's serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient's natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.
AB - Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62-66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient's serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient's natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.
KW - Humans
KW - Male
KW - Middle Aged
KW - Follow-Up Studies
KW - Lymphocyte Activation
KW - K562 Cells
KW - Tumor Cells, Cultured
KW - Antigens, CD/immunology
KW - T-Lymphocytes/immunology
KW - Cytotoxicity, Immunologic/immunology
KW - Immunity/immunology
KW - Killer Cells, Natural/immunology
KW - Leukemia, Myeloid, Acute/genetics/immunology
KW - Myeloid Cells/cytology/immunology
KW - Myeloid-Lymphoid Leukemia Protein/genetics/immunology
KW - Oncogene Proteins, Fusion/genetics/immunology
KW - Remission, Spontaneous
KW - Humans
KW - Male
KW - Middle Aged
KW - Follow-Up Studies
KW - Lymphocyte Activation
KW - K562 Cells
KW - Tumor Cells, Cultured
KW - Antigens, CD/immunology
KW - T-Lymphocytes/immunology
KW - Cytotoxicity, Immunologic/immunology
KW - Immunity/immunology
KW - Killer Cells, Natural/immunology
KW - Leukemia, Myeloid, Acute/genetics/immunology
KW - Myeloid Cells/cytology/immunology
KW - Myeloid-Lymphoid Leukemia Protein/genetics/immunology
KW - Oncogene Proteins, Fusion/genetics/immunology
KW - Remission, Spontaneous
M3 - SCORING: Journal article
VL - 91
SP - 27
EP - 32
JO - ANN HEMATOL
JF - ANN HEMATOL
SN - 0939-5555
IS - 1
M1 - 1
ER -
