Immune regulation in renal inflammation
Standard
Immune regulation in renal inflammation. / Neumann, Katrin; Tiegs, Gisa.
In: CELL TISSUE RES, Vol. 385, No. 2, 08.2021, p. 305-322.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Immune regulation in renal inflammation
AU - Neumann, Katrin
AU - Tiegs, Gisa
PY - 2021/8
Y1 - 2021/8
N2 - Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also innate immune responses in the inflamed kidney. However, there is also evidence for other immune cell populations with immunosuppressive function in renal inflammation. This review summarizes mechanisms of immune cell regulation in immune-mediated glomerulonephritis and acute and chronic nephrotoxicity.
AB - Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also innate immune responses in the inflamed kidney. However, there is also evidence for other immune cell populations with immunosuppressive function in renal inflammation. This review summarizes mechanisms of immune cell regulation in immune-mediated glomerulonephritis and acute and chronic nephrotoxicity.
U2 - 10.1007/s00441-020-03351-1
DO - 10.1007/s00441-020-03351-1
M3 - SCORING: Review article
C2 - 33496881
VL - 385
SP - 305
EP - 322
JO - CELL TISSUE RES
JF - CELL TISSUE RES
SN - 0302-766X
IS - 2
ER -