Immune Monitoring
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Immune Monitoring. / Berger, Susanna Carolina; Fehse, Boris; Rubio, Marie-Thérèse.
The EBMT/EHA CAR-T Cell Handbook. ed. / Nicolaus Kröger; John Gribben; Christian Chabannon; Ibrahim Yakoub-Agha; Hermann Einsele. 1. ed. Cham : Springer International Publishing, 2022. p. 177-182.Research output: SCORING: Contribution to book/anthology › Chapter › Research
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TY - CHAP
T1 - Immune Monitoring
AU - Berger, Susanna Carolina
AU - Fehse, Boris
AU - Rubio, Marie-Thérèse
PY - 2022
Y1 - 2022
N2 - CAR-T cell expansion and persistence are critical parameters for therapeutic efficacy and toxicity (Locke et al. 2020). However, CAR-T cells are patient-specific ‘living drugs’ with an unpredictable ability to expand in vivo. Thus, close postinfusion monitoring should be a major prerequisite to better manage this therapy. Critical parameters include CAR-T cell expansion kinetics and phenotype immune reconstitution and serum biomarkers (Fig. 35.1; Kalos et al. 2011; Hu and Huang 2020). Additionally, prospective collection and storage of patient specimens should be planned for future hypothesis-driven studies at specialized research centres. To date, despite the rapid expansion of CAR-T cell therapy, no standard recommendations exist for CAR monitoring, and harmonization of efforts across multiple centres is urgently needed.
AB - CAR-T cell expansion and persistence are critical parameters for therapeutic efficacy and toxicity (Locke et al. 2020). However, CAR-T cells are patient-specific ‘living drugs’ with an unpredictable ability to expand in vivo. Thus, close postinfusion monitoring should be a major prerequisite to better manage this therapy. Critical parameters include CAR-T cell expansion kinetics and phenotype immune reconstitution and serum biomarkers (Fig. 35.1; Kalos et al. 2011; Hu and Huang 2020). Additionally, prospective collection and storage of patient specimens should be planned for future hypothesis-driven studies at specialized research centres. To date, despite the rapid expansion of CAR-T cell therapy, no standard recommendations exist for CAR monitoring, and harmonization of efforts across multiple centres is urgently needed.
U2 - 10.1007/978-3-030-94353-0_35
DO - 10.1007/978-3-030-94353-0_35
M3 - Chapter
SN - 978-3-030-94352-3
SP - 177
EP - 182
BT - The EBMT/EHA CAR-T Cell Handbook
A2 - Kröger, Nicolaus
A2 - Gribben, John
A2 - Chabannon, Christian
A2 - Yakoub-Agha, Ibrahim
A2 - Einsele, Hermann
PB - Springer International Publishing
CY - Cham
ER -
