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Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model

Standard

Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model. / Deuse, Tobias; Ikeno, Fumiaki; Robbins, Robert C; Schrepfer, Sonja.

In: JOVE-J VIS EXP, No. 31, 14.09.2009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Deuse, T, Ikeno, F, Robbins, RC & Schrepfer, S 2009, 'Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model', JOVE-J VIS EXP, no. 31. https://doi.org/10.3791/1346

APA

Deuse, T., Ikeno, F., Robbins, R. C., & Schrepfer, S. (2009). Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model. JOVE-J VIS EXP, (31). https://doi.org/10.3791/1346

Vancouver

Deuse T, Ikeno F, Robbins RC, Schrepfer S. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model. JOVE-J VIS EXP. 2009 Sep 14;(31). https://doi.org/10.3791/1346

Bibtex

@article{7ffa954c58ef45b4b51ff8437e4775ba,
title = "Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model",
abstract = "Preclinical models of restenosis are essential to unravel the pathophysiological processes that lead to in-stent restenosis and to optimize existing and future drug-eluting stents. A variety of antibodies and transgenic and knockout strains are available in rats. Consequently, a model for in-stent restenosis in the rat would be convenient for pathobiological and pathophysiological studies. In this video, we present the full procedure and pit-falls of a rat stent model suitable for high throughput stent research. We will show the surgical procedure of stent deployment, and the assessment of in-stent restenosis using the most elegant technique of OCT (Optical Coherence Tomography). This technique provides high accuracy in assessing plaque CSAs (cross section areas) and correlates well with histological sections, which require special and time consuming embedding and sectioning techniques. OCT imaging further allows longitudinal monitoring of the development of in-stent restenosis within the same animal compared to one-time snapshots using histology.",
keywords = "Animals, Aorta, Abdominal/pathology, Arterial Occlusive Diseases/pathology, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley, Stents, Tunica Intima/pathology",
author = "Tobias Deuse and Fumiaki Ikeno and Robbins, {Robert C} and Sonja Schrepfer",
year = "2009",
month = sep,
day = "14",
doi = "10.3791/1346",
language = "English",
journal = "JOVE-J VIS EXP",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "31",

}

RIS

TY - JOUR

T1 - Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model

AU - Deuse, Tobias

AU - Ikeno, Fumiaki

AU - Robbins, Robert C

AU - Schrepfer, Sonja

PY - 2009/9/14

Y1 - 2009/9/14

N2 - Preclinical models of restenosis are essential to unravel the pathophysiological processes that lead to in-stent restenosis and to optimize existing and future drug-eluting stents. A variety of antibodies and transgenic and knockout strains are available in rats. Consequently, a model for in-stent restenosis in the rat would be convenient for pathobiological and pathophysiological studies. In this video, we present the full procedure and pit-falls of a rat stent model suitable for high throughput stent research. We will show the surgical procedure of stent deployment, and the assessment of in-stent restenosis using the most elegant technique of OCT (Optical Coherence Tomography). This technique provides high accuracy in assessing plaque CSAs (cross section areas) and correlates well with histological sections, which require special and time consuming embedding and sectioning techniques. OCT imaging further allows longitudinal monitoring of the development of in-stent restenosis within the same animal compared to one-time snapshots using histology.

AB - Preclinical models of restenosis are essential to unravel the pathophysiological processes that lead to in-stent restenosis and to optimize existing and future drug-eluting stents. A variety of antibodies and transgenic and knockout strains are available in rats. Consequently, a model for in-stent restenosis in the rat would be convenient for pathobiological and pathophysiological studies. In this video, we present the full procedure and pit-falls of a rat stent model suitable for high throughput stent research. We will show the surgical procedure of stent deployment, and the assessment of in-stent restenosis using the most elegant technique of OCT (Optical Coherence Tomography). This technique provides high accuracy in assessing plaque CSAs (cross section areas) and correlates well with histological sections, which require special and time consuming embedding and sectioning techniques. OCT imaging further allows longitudinal monitoring of the development of in-stent restenosis within the same animal compared to one-time snapshots using histology.

KW - Animals

KW - Aorta, Abdominal/pathology

KW - Arterial Occlusive Diseases/pathology

KW - Disease Models, Animal

KW - Male

KW - Rats

KW - Rats, Sprague-Dawley

KW - Stents

KW - Tunica Intima/pathology

U2 - 10.3791/1346

DO - 10.3791/1346

M3 - SCORING: Journal article

C2 - 19752856

JO - JOVE-J VIS EXP

JF - JOVE-J VIS EXP

SN - 1940-087X

IS - 31

ER -