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IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks

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IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. / Meyer, Christian G; Calixto Fernandes, Maria H; Intemann, Christopher D; Kreuels, Benno; Kobbe, Robin; Kreuzberg, Christina; Ayim, Matilda; Ruether, Andreas; Loag, Wibke; Ehmen, Christa; Adjei, Samuel; Adjei, Ohene; Horstmann, Rolf D; May, Jürgen.

In: HUM MOL GENET, Vol. 20, No. 6, 15.03.2011, p. 1173-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, CG, Calixto Fernandes, MH, Intemann, CD, Kreuels, B, Kobbe, R, Kreuzberg, C, Ayim, M, Ruether, A, Loag, W, Ehmen, C, Adjei, S, Adjei, O, Horstmann, RD & May, J 2011, 'IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks', HUM MOL GENET, vol. 20, no. 6, pp. 1173-81. https://doi.org/10.1093/hmg/ddq562

APA

Meyer, C. G., Calixto Fernandes, M. H., Intemann, C. D., Kreuels, B., Kobbe, R., Kreuzberg, C., Ayim, M., Ruether, A., Loag, W., Ehmen, C., Adjei, S., Adjei, O., Horstmann, R. D., & May, J. (2011). IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. HUM MOL GENET, 20(6), 1173-81. https://doi.org/10.1093/hmg/ddq562

Vancouver

Meyer CG, Calixto Fernandes MH, Intemann CD, Kreuels B, Kobbe R, Kreuzberg C et al. IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. HUM MOL GENET. 2011 Mar 15;20(6):1173-81. https://doi.org/10.1093/hmg/ddq562

Bibtex

@article{34759e7d851741b7884b7f7e4373f440,
title = "IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks",
abstract = "Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31-33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have not yet been identified for this chromosomal region. In order to perform association analyses of 5q31-33 locus candidate single nucleotide polymorphisms (SNPs), 1015 children were recruited at the age of 3 months and followed monthly until the age of 2 years in an area holoendemic for Plasmodium falciparum malaria in Ghana. Quantitative (incidence rates of malaria episodes) and qualitative phenotypes (i.e. 'more than one malaria episode' or 'not more than one malaria episode') were used in population- and family-based analyses. The strongest signal was observed for the interleukin 3 gene (IL3) SNP rs40401 (P = 3.4 × 10(-7), P(c)= 1.4 × 10(-4)). The IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect of 25% [incidence rate ratio (IRR) 0.75, P = 4.1 × 10(-5)] and 33% (IRR 0.67, P = 3.2 × 10(-8)), respectively, against malaria attacks. The association was confirmed in transmission disequilibrium tests (TDT, qTDT). The results could argue for a role of IL3 in the pathophysiology of falciparum malaria.",
keywords = "Child, Preschool, Chromosomes, Human, Pair 5, Female, Genetic Variation, Ghana, Humans, Immunity, Innate, Infant, Interleukin-3, Malaria, Falciparum, Male, Plasmodium falciparum, Polymorphism, Single Nucleotide, Recurrence",
author = "Meyer, {Christian G} and {Calixto Fernandes}, {Maria H} and Intemann, {Christopher D} and Benno Kreuels and Robin Kobbe and Christina Kreuzberg and Matilda Ayim and Andreas Ruether and Wibke Loag and Christa Ehmen and Samuel Adjei and Ohene Adjei and Horstmann, {Rolf D} and J{\"u}rgen May",
year = "2011",
month = mar,
day = "15",
doi = "10.1093/hmg/ddq562",
language = "English",
volume = "20",
pages = "1173--81",
journal = "HUM MOL GENET",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks

AU - Meyer, Christian G

AU - Calixto Fernandes, Maria H

AU - Intemann, Christopher D

AU - Kreuels, Benno

AU - Kobbe, Robin

AU - Kreuzberg, Christina

AU - Ayim, Matilda

AU - Ruether, Andreas

AU - Loag, Wibke

AU - Ehmen, Christa

AU - Adjei, Samuel

AU - Adjei, Ohene

AU - Horstmann, Rolf D

AU - May, Jürgen

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31-33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have not yet been identified for this chromosomal region. In order to perform association analyses of 5q31-33 locus candidate single nucleotide polymorphisms (SNPs), 1015 children were recruited at the age of 3 months and followed monthly until the age of 2 years in an area holoendemic for Plasmodium falciparum malaria in Ghana. Quantitative (incidence rates of malaria episodes) and qualitative phenotypes (i.e. 'more than one malaria episode' or 'not more than one malaria episode') were used in population- and family-based analyses. The strongest signal was observed for the interleukin 3 gene (IL3) SNP rs40401 (P = 3.4 × 10(-7), P(c)= 1.4 × 10(-4)). The IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect of 25% [incidence rate ratio (IRR) 0.75, P = 4.1 × 10(-5)] and 33% (IRR 0.67, P = 3.2 × 10(-8)), respectively, against malaria attacks. The association was confirmed in transmission disequilibrium tests (TDT, qTDT). The results could argue for a role of IL3 in the pathophysiology of falciparum malaria.

AB - Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31-33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have not yet been identified for this chromosomal region. In order to perform association analyses of 5q31-33 locus candidate single nucleotide polymorphisms (SNPs), 1015 children were recruited at the age of 3 months and followed monthly until the age of 2 years in an area holoendemic for Plasmodium falciparum malaria in Ghana. Quantitative (incidence rates of malaria episodes) and qualitative phenotypes (i.e. 'more than one malaria episode' or 'not more than one malaria episode') were used in population- and family-based analyses. The strongest signal was observed for the interleukin 3 gene (IL3) SNP rs40401 (P = 3.4 × 10(-7), P(c)= 1.4 × 10(-4)). The IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect of 25% [incidence rate ratio (IRR) 0.75, P = 4.1 × 10(-5)] and 33% (IRR 0.67, P = 3.2 × 10(-8)), respectively, against malaria attacks. The association was confirmed in transmission disequilibrium tests (TDT, qTDT). The results could argue for a role of IL3 in the pathophysiology of falciparum malaria.

KW - Child, Preschool

KW - Chromosomes, Human, Pair 5

KW - Female

KW - Genetic Variation

KW - Ghana

KW - Humans

KW - Immunity, Innate

KW - Infant

KW - Interleukin-3

KW - Malaria, Falciparum

KW - Male

KW - Plasmodium falciparum

KW - Polymorphism, Single Nucleotide

KW - Recurrence

U2 - 10.1093/hmg/ddq562

DO - 10.1093/hmg/ddq562

M3 - SCORING: Journal article

C2 - 21224257

VL - 20

SP - 1173

EP - 1181

JO - HUM MOL GENET

JF - HUM MOL GENET

SN - 0964-6906

IS - 6

ER -