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IL-22BP controls the progression of liver metastasis in colorectal cancer

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IL-22BP controls the progression of liver metastasis in colorectal cancer. / Giannou, Anastasios D; Kempski, Jan; Zhang, Tao; Lücke, Jöran; Shiri, Ahmad Mustafa; Zazara, Dimitra E; Belios, Ioannis; Machicote, Andres; Seeger, Philipp; Agalioti, Theodora; Tintelnot, Joseph; Sagebiel, Adrian; Tomczak, Miriam; Bauditz, Lennart; Bedke, Tanja; Kocheise, Lorenz; Mercanoglu, Baris; Fard-Aghaie, Mohammad; Giorgakis, Emmanouil; Lykoudis, Panagis M; Pikouli, Anastasia; Grass, Julia-Kristin; Wahib, Ramez; Bardenhagen, Jan; Brunswig, Benjamin; Heumann, Asmus; Ghadban, Tarik; Duprée, Anna; Tachezy, Michael; Melling, Nathaniel; Arck, Petra C; Stringa, Pablo; Gentilini, Maria Virginia; Gondolesi, Gabriel E; Nakano, Ryosuke; Thomson, Angus W; Perez, Daniel; Li, Jun; Mann, Oliver; Izbicki, Jakob R; Gagliani, Nicola; Maroulis, Ioannis C; Huber, Samuel.

In: FRONT ONCOL, Vol. 13, 2023, p. 1170502.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Giannou, AD, Kempski, J, Zhang, T, Lücke, J, Shiri, AM, Zazara, DE, Belios, I, Machicote, A, Seeger, P, Agalioti, T, Tintelnot, J, Sagebiel, A, Tomczak, M, Bauditz, L, Bedke, T, Kocheise, L, Mercanoglu, B, Fard-Aghaie, M, Giorgakis, E, Lykoudis, PM, Pikouli, A, Grass, J-K, Wahib, R, Bardenhagen, J, Brunswig, B, Heumann, A, Ghadban, T, Duprée, A, Tachezy, M, Melling, N, Arck, PC, Stringa, P, Gentilini, MV, Gondolesi, GE, Nakano, R, Thomson, AW, Perez, D, Li, J, Mann, O, Izbicki, JR, Gagliani, N, Maroulis, IC & Huber, S 2023, 'IL-22BP controls the progression of liver metastasis in colorectal cancer', FRONT ONCOL, vol. 13, pp. 1170502. https://doi.org/10.3389/fonc.2023.1170502

APA

Giannou, A. D., Kempski, J., Zhang, T., Lücke, J., Shiri, A. M., Zazara, D. E., Belios, I., Machicote, A., Seeger, P., Agalioti, T., Tintelnot, J., Sagebiel, A., Tomczak, M., Bauditz, L., Bedke, T., Kocheise, L., Mercanoglu, B., Fard-Aghaie, M., Giorgakis, E., ... Huber, S. (2023). IL-22BP controls the progression of liver metastasis in colorectal cancer. FRONT ONCOL, 13, 1170502. https://doi.org/10.3389/fonc.2023.1170502

Vancouver

Giannou AD, Kempski J, Zhang T, Lücke J, Shiri AM, Zazara DE et al. IL-22BP controls the progression of liver metastasis in colorectal cancer. FRONT ONCOL. 2023;13:1170502. https://doi.org/10.3389/fonc.2023.1170502

Bibtex

@article{8785a97ad77644c79707a7c88324f04f,
title = "IL-22BP controls the progression of liver metastasis in colorectal cancer",
abstract = "BACKGROUND: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown.METHODS: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages.RESULTS: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice.CONCLUSIONS: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC.",
author = "Giannou, {Anastasios D} and Jan Kempski and Tao Zhang and J{\"o}ran L{\"u}cke and Shiri, {Ahmad Mustafa} and Zazara, {Dimitra E} and Ioannis Belios and Andres Machicote and Philipp Seeger and Theodora Agalioti and Joseph Tintelnot and Adrian Sagebiel and Miriam Tomczak and Lennart Bauditz and Tanja Bedke and Lorenz Kocheise and Baris Mercanoglu and Mohammad Fard-Aghaie and Emmanouil Giorgakis and Lykoudis, {Panagis M} and Anastasia Pikouli and Julia-Kristin Grass and Ramez Wahib and Jan Bardenhagen and Benjamin Brunswig and Asmus Heumann and Tarik Ghadban and Anna Dupr{\'e}e and Michael Tachezy and Nathaniel Melling and Arck, {Petra C} and Pablo Stringa and Gentilini, {Maria Virginia} and Gondolesi, {Gabriel E} and Ryosuke Nakano and Thomson, {Angus W} and Daniel Perez and Jun Li and Oliver Mann and Izbicki, {Jakob R} and Nicola Gagliani and Maroulis, {Ioannis C} and Samuel Huber",
note = "Copyright {\textcopyright} 2023 Giannou, Kempski, Zhang, L{\"u}cke, Shiri, Zazara, Belios, Machicote, Seeger, Agalioti, Tintelnot, Sagebiel, Tomczak, Bauditz, Bedke, Kocheise, Mercanoglu, Fard-Aghaie, Giorgakis, Lykoudis, Pikouli, Grass, Wahib, Bardenhagen, Brunswig, Heumann, Ghadban, Dupr{\'e}e, Tachezy, Melling, Arck, Stringa, Gentilini, Gondolesi, Nakano, Thomson, Perez, Li, Mann, Izbicki, Gagliani, Maroulis and Huber.",
year = "2023",
doi = "10.3389/fonc.2023.1170502",
language = "English",
volume = "13",
pages = "1170502",
journal = "FRONT ONCOL",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - IL-22BP controls the progression of liver metastasis in colorectal cancer

AU - Giannou, Anastasios D

AU - Kempski, Jan

AU - Zhang, Tao

AU - Lücke, Jöran

AU - Shiri, Ahmad Mustafa

AU - Zazara, Dimitra E

AU - Belios, Ioannis

AU - Machicote, Andres

AU - Seeger, Philipp

AU - Agalioti, Theodora

AU - Tintelnot, Joseph

AU - Sagebiel, Adrian

AU - Tomczak, Miriam

AU - Bauditz, Lennart

AU - Bedke, Tanja

AU - Kocheise, Lorenz

AU - Mercanoglu, Baris

AU - Fard-Aghaie, Mohammad

AU - Giorgakis, Emmanouil

AU - Lykoudis, Panagis M

AU - Pikouli, Anastasia

AU - Grass, Julia-Kristin

AU - Wahib, Ramez

AU - Bardenhagen, Jan

AU - Brunswig, Benjamin

AU - Heumann, Asmus

AU - Ghadban, Tarik

AU - Duprée, Anna

AU - Tachezy, Michael

AU - Melling, Nathaniel

AU - Arck, Petra C

AU - Stringa, Pablo

AU - Gentilini, Maria Virginia

AU - Gondolesi, Gabriel E

AU - Nakano, Ryosuke

AU - Thomson, Angus W

AU - Perez, Daniel

AU - Li, Jun

AU - Mann, Oliver

AU - Izbicki, Jakob R

AU - Gagliani, Nicola

AU - Maroulis, Ioannis C

AU - Huber, Samuel

N1 - Copyright © 2023 Giannou, Kempski, Zhang, Lücke, Shiri, Zazara, Belios, Machicote, Seeger, Agalioti, Tintelnot, Sagebiel, Tomczak, Bauditz, Bedke, Kocheise, Mercanoglu, Fard-Aghaie, Giorgakis, Lykoudis, Pikouli, Grass, Wahib, Bardenhagen, Brunswig, Heumann, Ghadban, Duprée, Tachezy, Melling, Arck, Stringa, Gentilini, Gondolesi, Nakano, Thomson, Perez, Li, Mann, Izbicki, Gagliani, Maroulis and Huber.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown.METHODS: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages.RESULTS: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice.CONCLUSIONS: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC.

AB - BACKGROUND: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown.METHODS: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages.RESULTS: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice.CONCLUSIONS: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC.

U2 - 10.3389/fonc.2023.1170502

DO - 10.3389/fonc.2023.1170502

M3 - SCORING: Journal article

C2 - 37324022

VL - 13

SP - 1170502

JO - FRONT ONCOL

JF - FRONT ONCOL

SN - 2234-943X

ER -