IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
Standard
IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. / Tzartos, John S; Craner, Matthew J; Friese, Manuel A.; Jakobsen, Karen B; Newcombe, Jia; Esiri, Margaret M; Fugger, Lars.
In: AM J PATHOL, Vol. 178, No. 2, 2, 2011, p. 794-802.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
AU - Tzartos, John S
AU - Craner, Matthew J
AU - Friese, Manuel A.
AU - Jakobsen, Karen B
AU - Newcombe, Jia
AU - Esiri, Margaret M
AU - Fugger, Lars
PY - 2011
Y1 - 2011
N2 - IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor- ). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21(+) infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4(+) cells. In contrast, IL-21R was much more broadly distributed on CD4(+), CD19(+), and CD8(+) lymphocytes but not major histocompatibility complex class-II(+) macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons.
AB - IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor- ). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21(+) infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4(+) cells. In contrast, IL-21R was much more broadly distributed on CD4(+), CD19(+), and CD8(+) lymphocytes but not major histocompatibility complex class-II(+) macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons.
M3 - SCORING: Zeitschriftenaufsatz
VL - 178
SP - 794
EP - 802
JO - AM J PATHOL
JF - AM J PATHOL
SN - 0002-9440
IS - 2
M1 - 2
ER -
