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IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.

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IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. / Alter, Galit; Kavanagh, Daniel; Rihn, Suzannah; Luteijn, Rutger; Brooks, David; Oldstone, Michael; van Lunzen, Jan; Altfeld, Marcus.

In: J CLIN INVEST, Vol. 120, No. 6, 6, 2010, p. 1905-1913.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Alter, G, Kavanagh, D, Rihn, S, Luteijn, R, Brooks, D, Oldstone, M, van Lunzen, J & Altfeld, M 2010, 'IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.', J CLIN INVEST, vol. 120, no. 6, 6, pp. 1905-1913. <http://www.ncbi.nlm.nih.gov/pubmed/20440075?dopt=Citation>

APA

Alter, G., Kavanagh, D., Rihn, S., Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J., & Altfeld, M. (2010). IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J CLIN INVEST, 120(6), 1905-1913. [6]. http://www.ncbi.nlm.nih.gov/pubmed/20440075?dopt=Citation

Vancouver

Alter G, Kavanagh D, Rihn S, Luteijn R, Brooks D, Oldstone M et al. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J CLIN INVEST. 2010;120(6):1905-1913. 6.

Bibtex

@article{520c74e30e804f56a11b3f64109d6e5f,
title = "IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.",
abstract = "Persistent levels of IL-10 play a central role in progressive immune dysfunction associated with chronic viral infections such as HIV, but the underlying mechanisms are poorly understood. Because IL-10 affects the phenotypic and functional properties of DCs, which are responsible for initiating adaptive immune responses, we investigated whether IL-10 induces changes in DC phenotype and function in the context of HIV infection. Here, we show that IL-10 treatment of immature and mature human DCs in culture induced contrasting phenotypic changes in these populations: immature DCs exhibited aberrant resistance to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-dependent NK elimination. Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion and the same phenotypic and functional changes observed in the IL-10-treated cells. Consistent with these in vitro data, LNs isolated from individuals infected with HIV exhibited aberrant accumulation of a partially {"}immature{"} DC population. Together, these data suggest that the progressive immune dysfunction observed in chronic viral infections might be caused in part by IL-10-induced reversal of DC susceptibility to NK cell-mediated elimination, resulting in the accumulation of poorly immunogenic DCs in LNs, the sites of adaptive immune response induction.",
keywords = "Humans, HIV Infections immunology, Cell Differentiation immunology, Dendritic Cells cytology, HIV immunology, Interleukin-10 immunology, Killer Cells, Natural immunology, Humans, HIV Infections immunology, Cell Differentiation immunology, Dendritic Cells cytology, HIV immunology, Interleukin-10 immunology, Killer Cells, Natural immunology",
author = "Galit Alter and Daniel Kavanagh and Suzannah Rihn and Rutger Luteijn and David Brooks and Michael Oldstone and {van Lunzen}, Jan and Marcus Altfeld",
year = "2010",
language = "Deutsch",
volume = "120",
pages = "1905--1913",
journal = "J CLIN INVEST",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "6",

}

RIS

TY - JOUR

T1 - IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.

AU - Alter, Galit

AU - Kavanagh, Daniel

AU - Rihn, Suzannah

AU - Luteijn, Rutger

AU - Brooks, David

AU - Oldstone, Michael

AU - van Lunzen, Jan

AU - Altfeld, Marcus

PY - 2010

Y1 - 2010

N2 - Persistent levels of IL-10 play a central role in progressive immune dysfunction associated with chronic viral infections such as HIV, but the underlying mechanisms are poorly understood. Because IL-10 affects the phenotypic and functional properties of DCs, which are responsible for initiating adaptive immune responses, we investigated whether IL-10 induces changes in DC phenotype and function in the context of HIV infection. Here, we show that IL-10 treatment of immature and mature human DCs in culture induced contrasting phenotypic changes in these populations: immature DCs exhibited aberrant resistance to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-dependent NK elimination. Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion and the same phenotypic and functional changes observed in the IL-10-treated cells. Consistent with these in vitro data, LNs isolated from individuals infected with HIV exhibited aberrant accumulation of a partially "immature" DC population. Together, these data suggest that the progressive immune dysfunction observed in chronic viral infections might be caused in part by IL-10-induced reversal of DC susceptibility to NK cell-mediated elimination, resulting in the accumulation of poorly immunogenic DCs in LNs, the sites of adaptive immune response induction.

AB - Persistent levels of IL-10 play a central role in progressive immune dysfunction associated with chronic viral infections such as HIV, but the underlying mechanisms are poorly understood. Because IL-10 affects the phenotypic and functional properties of DCs, which are responsible for initiating adaptive immune responses, we investigated whether IL-10 induces changes in DC phenotype and function in the context of HIV infection. Here, we show that IL-10 treatment of immature and mature human DCs in culture induced contrasting phenotypic changes in these populations: immature DCs exhibited aberrant resistance to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-dependent NK elimination. Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion and the same phenotypic and functional changes observed in the IL-10-treated cells. Consistent with these in vitro data, LNs isolated from individuals infected with HIV exhibited aberrant accumulation of a partially "immature" DC population. Together, these data suggest that the progressive immune dysfunction observed in chronic viral infections might be caused in part by IL-10-induced reversal of DC susceptibility to NK cell-mediated elimination, resulting in the accumulation of poorly immunogenic DCs in LNs, the sites of adaptive immune response induction.

KW - Humans

KW - HIV Infections immunology

KW - Cell Differentiation immunology

KW - Dendritic Cells cytology

KW - HIV immunology

KW - Interleukin-10 immunology

KW - Killer Cells, Natural immunology

KW - Humans

KW - HIV Infections immunology

KW - Cell Differentiation immunology

KW - Dendritic Cells cytology

KW - HIV immunology

KW - Interleukin-10 immunology

KW - Killer Cells, Natural immunology

M3 - SCORING: Zeitschriftenaufsatz

VL - 120

SP - 1905

EP - 1913

JO - J CLIN INVEST

JF - J CLIN INVEST

SN - 0021-9738

IS - 6

M1 - 6

ER -