Research ExplorerPublicationsIFITM proteins drive type 2 T helper cell differentiation an...

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

Standard

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. / Yánez, Diana C; Sahni, Hemant; Ross, Susan; Solanki, Anisha; Lau, Ching-In; Papaioannou, Eleftheria; Barbarulo, Alessandro; Powell, Rebecca; Lange, Ulrike C; Adams, David J; Barenco, Martino; Ono, Masahiro; D'Acquisto, Fulvio; Furmanski, Anna L; Crompton, Tessa.

In: EUR J IMMUNOL, Vol. 49, No. 1, 01.2019, p. 66-78.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yánez, DC, Sahni, H, Ross, S, Solanki, A, Lau, C-I, Papaioannou, E, Barbarulo, A, Powell, R, Lange, UC, Adams, DJ, Barenco, M, Ono, M, D'Acquisto, F, Furmanski, AL & Crompton, T 2019, 'IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation', EUR J IMMUNOL, vol. 49, no. 1, pp. 66-78. https://doi.org/10.1002/eji.201847692

APA

Yánez, D. C., Sahni, H., Ross, S., Solanki, A., Lau, C-I., Papaioannou, E., Barbarulo, A., Powell, R., Lange, U. C., Adams, D. J., Barenco, M., Ono, M., D'Acquisto, F., Furmanski, A. L., & Crompton, T. (2019). IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. EUR J IMMUNOL, 49(1), 66-78. https://doi.org/10.1002/eji.201847692

Vancouver

Yánez DC, Sahni H, Ross S, Solanki A, Lau C-I, Papaioannou E et al. IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. EUR J IMMUNOL. 2019 Jan;49(1):66-78. https://doi.org/10.1002/eji.201847692

Bibtex

@article{970c89285314419f849a12dfbcadf38f,
title = "IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation",
abstract = "The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4+ Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild-type (WT) CD4+ T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm-family-deficient CD4+ T cells had higher expression of Th1-associated genes than WT and purified naive Ifitm-family-deficient CD4+ T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.",
keywords = "Animals, Cell Differentiation/genetics, Cells, Cultured, Hypersensitivity/immunology, Inflammation/immunology, Interferon-gamma/metabolism, Interleukin-27/metabolism, Interleukin-4/metabolism, Lymphocyte Activation/genetics, Membrane Proteins/genetics, Mice, Mice, Inbred C57BL, Mice, Knockout, Respiratory System/immunology, Th1 Cells/immunology, Th1-Th2 Balance/genetics, Th2 Cells/immunology",
author = "Y{\'a}nez, {Diana C} and Hemant Sahni and Susan Ross and Anisha Solanki and Ching-In Lau and Eleftheria Papaioannou and Alessandro Barbarulo and Rebecca Powell and Lange, {Ulrike C} and Adams, {David J} and Martino Barenco and Masahiro Ono and Fulvio D'Acquisto and Furmanski, {Anna L} and Tessa Crompton",
note = "{\textcopyright} 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2019",
month = jan,
doi = "10.1002/eji.201847692",
language = "English",
volume = "49",
pages = "66--78",
journal = "EUR J IMMUNOL",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH",
number = "1",

}

RIS

TY - JOUR

T1 - IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

AU - Yánez, Diana C

AU - Sahni, Hemant

AU - Ross, Susan

AU - Solanki, Anisha

AU - Lau, Ching-In

AU - Papaioannou, Eleftheria

AU - Barbarulo, Alessandro

AU - Powell, Rebecca

AU - Lange, Ulrike C

AU - Adams, David J

AU - Barenco, Martino

AU - Ono, Masahiro

AU - D'Acquisto, Fulvio

AU - Furmanski, Anna L

AU - Crompton, Tessa

N1 - © 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2019/1

Y1 - 2019/1

N2 - The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4+ Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild-type (WT) CD4+ T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm-family-deficient CD4+ T cells had higher expression of Th1-associated genes than WT and purified naive Ifitm-family-deficient CD4+ T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

AB - The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4+ Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild-type (WT) CD4+ T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm-family-deficient CD4+ T cells had higher expression of Th1-associated genes than WT and purified naive Ifitm-family-deficient CD4+ T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

KW - Animals

KW - Cell Differentiation/genetics

KW - Cells, Cultured

KW - Hypersensitivity/immunology

KW - Inflammation/immunology

KW - Interferon-gamma/metabolism

KW - Interleukin-27/metabolism

KW - Interleukin-4/metabolism

KW - Lymphocyte Activation/genetics

KW - Membrane Proteins/genetics

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Respiratory System/immunology

KW - Th1 Cells/immunology

KW - Th1-Th2 Balance/genetics

KW - Th2 Cells/immunology

U2 - 10.1002/eji.201847692

DO - 10.1002/eji.201847692

M3 - SCORING: Journal article

C2 - 30365177

VL - 49

SP - 66

EP - 78

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 1

ER -