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Identification of sensory blockade by somatosensory and pain-induced evoked potentials

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Identification of sensory blockade by somatosensory and pain-induced evoked potentials. / Schmidt, Gunter Niels; Scharein, Eckehard; Siegel, Markus; Müller, Jakob; Debener, Stefan; Nitzschke, Rainer; Engel, Andreas K.; Bischoff, Petra.

In: ANESTHESIOLOGY, Vol. 106, No. 4, 4, 04.2007, p. 707-714.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schmidt, GN, Scharein, E, Siegel, M, Müller, J, Debener, S, Nitzschke, R, Engel, AK & Bischoff, P 2007, 'Identification of sensory blockade by somatosensory and pain-induced evoked potentials', ANESTHESIOLOGY, vol. 106, no. 4, 4, pp. 707-714. https://doi.org/10.1097/01.anes.0000264774.09910.c6

APA

Schmidt, G. N., Scharein, E., Siegel, M., Müller, J., Debener, S., Nitzschke, R., Engel, A. K., & Bischoff, P. (2007). Identification of sensory blockade by somatosensory and pain-induced evoked potentials. ANESTHESIOLOGY, 106(4), 707-714. [4]. https://doi.org/10.1097/01.anes.0000264774.09910.c6

Vancouver

Schmidt GN, Scharein E, Siegel M, Müller J, Debener S, Nitzschke R et al. Identification of sensory blockade by somatosensory and pain-induced evoked potentials. ANESTHESIOLOGY. 2007 Apr;106(4):707-714. 4. https://doi.org/10.1097/01.anes.0000264774.09910.c6

Bibtex

@article{25eeacdc8e1142e89740c4e7804f5d29,
title = "Identification of sensory blockade by somatosensory and pain-induced evoked potentials",
abstract = "BACKGROUND: To date, the anesthesia-induced blockade of nociceptive inputs is insufficiently reflected by commercially available electroencephalographic depth-of-anesthesia monitors. The aim of the current study was to evaluate the potential of somatosensory (SSEP) and intracutaneous pain evoked (iSEP) potentials during remifentanil and propofol anesthesia as electroencephalographic indicators of the nociceptive blockade.METHODS: Ten healthy men were investigated in a double-blind crossover design during three sessions with remifentanil, propofol, and placebo administration. All dosages were increased in a step-by-step mode. SSEP and iSEP recordings were performed followed by subjective pain ratings and measurement of level of sedation (modified Observer's Assessment of Alertness and Sedation Scale). Changes from baseline in evoked potential components, pain ratings, and sedation scale were assessed by Bonferroni-Holms-corrected Wilcoxon tests.RESULTS: Pain ratings were significantly reduced by remifentanil. Sedation scale was significantly reduced by propofol. Early SSEP components were not affected by medication. The amplitudes of the long latency SSEP components increased significantly with remifentanil, decreased with propofol, and did not change with placebo. The amplitudes of long latency components of the iSEP decreased significantly with both remifentanil and propofol and did not change with placebo.CONCLUSION: Long latency components of the SSEP are differently affected by remifentanil and propofol administration. Further studies are needed to clarify whether they can serve as a specific indicator of the nociceptive blockade during anesthesia.",
keywords = "Adult, Analgesics, Opioid/pharmacology, Double-Blind Method, Electroencephalography/drug effects, Evoked Potentials/drug effects, Evoked Potentials, Somatosensory/drug effects, Humans, Hypnotics and Sedatives/pharmacology, Male, Pain/physiopathology, Piperidines/pharmacology, Propofol/pharmacology, Remifentanil",
author = "Schmidt, {Gunter Niels} and Eckehard Scharein and Markus Siegel and Jakob M{\"u}ller and Stefan Debener and Rainer Nitzschke and Engel, {Andreas K.} and Petra Bischoff",
year = "2007",
month = apr,
doi = "10.1097/01.anes.0000264774.09910.c6",
language = "English",
volume = "106",
pages = "707--714",
journal = "ANESTHESIOLOGY",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Identification of sensory blockade by somatosensory and pain-induced evoked potentials

AU - Schmidt, Gunter Niels

AU - Scharein, Eckehard

AU - Siegel, Markus

AU - Müller, Jakob

AU - Debener, Stefan

AU - Nitzschke, Rainer

AU - Engel, Andreas K.

AU - Bischoff, Petra

PY - 2007/4

Y1 - 2007/4

N2 - BACKGROUND: To date, the anesthesia-induced blockade of nociceptive inputs is insufficiently reflected by commercially available electroencephalographic depth-of-anesthesia monitors. The aim of the current study was to evaluate the potential of somatosensory (SSEP) and intracutaneous pain evoked (iSEP) potentials during remifentanil and propofol anesthesia as electroencephalographic indicators of the nociceptive blockade.METHODS: Ten healthy men were investigated in a double-blind crossover design during three sessions with remifentanil, propofol, and placebo administration. All dosages were increased in a step-by-step mode. SSEP and iSEP recordings were performed followed by subjective pain ratings and measurement of level of sedation (modified Observer's Assessment of Alertness and Sedation Scale). Changes from baseline in evoked potential components, pain ratings, and sedation scale were assessed by Bonferroni-Holms-corrected Wilcoxon tests.RESULTS: Pain ratings were significantly reduced by remifentanil. Sedation scale was significantly reduced by propofol. Early SSEP components were not affected by medication. The amplitudes of the long latency SSEP components increased significantly with remifentanil, decreased with propofol, and did not change with placebo. The amplitudes of long latency components of the iSEP decreased significantly with both remifentanil and propofol and did not change with placebo.CONCLUSION: Long latency components of the SSEP are differently affected by remifentanil and propofol administration. Further studies are needed to clarify whether they can serve as a specific indicator of the nociceptive blockade during anesthesia.

AB - BACKGROUND: To date, the anesthesia-induced blockade of nociceptive inputs is insufficiently reflected by commercially available electroencephalographic depth-of-anesthesia monitors. The aim of the current study was to evaluate the potential of somatosensory (SSEP) and intracutaneous pain evoked (iSEP) potentials during remifentanil and propofol anesthesia as electroencephalographic indicators of the nociceptive blockade.METHODS: Ten healthy men were investigated in a double-blind crossover design during three sessions with remifentanil, propofol, and placebo administration. All dosages were increased in a step-by-step mode. SSEP and iSEP recordings were performed followed by subjective pain ratings and measurement of level of sedation (modified Observer's Assessment of Alertness and Sedation Scale). Changes from baseline in evoked potential components, pain ratings, and sedation scale were assessed by Bonferroni-Holms-corrected Wilcoxon tests.RESULTS: Pain ratings were significantly reduced by remifentanil. Sedation scale was significantly reduced by propofol. Early SSEP components were not affected by medication. The amplitudes of the long latency SSEP components increased significantly with remifentanil, decreased with propofol, and did not change with placebo. The amplitudes of long latency components of the iSEP decreased significantly with both remifentanil and propofol and did not change with placebo.CONCLUSION: Long latency components of the SSEP are differently affected by remifentanil and propofol administration. Further studies are needed to clarify whether they can serve as a specific indicator of the nociceptive blockade during anesthesia.

KW - Adult

KW - Analgesics, Opioid/pharmacology

KW - Double-Blind Method

KW - Electroencephalography/drug effects

KW - Evoked Potentials/drug effects

KW - Evoked Potentials, Somatosensory/drug effects

KW - Humans

KW - Hypnotics and Sedatives/pharmacology

KW - Male

KW - Pain/physiopathology

KW - Piperidines/pharmacology

KW - Propofol/pharmacology

KW - Remifentanil

U2 - 10.1097/01.anes.0000264774.09910.c6

DO - 10.1097/01.anes.0000264774.09910.c6

M3 - SCORING: Journal article

C2 - 17413908

VL - 106

SP - 707

EP - 714

JO - ANESTHESIOLOGY

JF - ANESTHESIOLOGY

SN - 0003-3022

IS - 4

M1 - 4

ER -