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Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans

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Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans. / Harrer, Caroline E; Mayer, Leonie; Fathi, Anahita; Lassen, Susan; Ly, My L; Zinser, Madeleine E; Wolf, Timo; Becker, Stephan; Sutter, Gerd; Dahlke, Christine; Addo, Marylyn M; MVA-MERS-S Study Group.

In: J INFECT DIS, Vol. 230, No. 2, 16.08.2024, p. e327-e332.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Harrer, CE, Mayer, L, Fathi, A, Lassen, S, Ly, ML, Zinser, ME, Wolf, T, Becker, S, Sutter, G, Dahlke, C, Addo, MM & MVA-MERS-S Study Group 2024, 'Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans', J INFECT DIS, vol. 230, no. 2, pp. e327-e332. https://doi.org/10.1093/infdis/jiad612

APA

Harrer, C. E., Mayer, L., Fathi, A., Lassen, S., Ly, M. L., Zinser, M. E., Wolf, T., Becker, S., Sutter, G., Dahlke, C., Addo, M. M., & MVA-MERS-S Study Group (2024). Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans. J INFECT DIS, 230(2), e327-e332. https://doi.org/10.1093/infdis/jiad612

Vancouver

Harrer CE, Mayer L, Fathi A, Lassen S, Ly ML, Zinser ME et al. Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans. J INFECT DIS. 2024 Aug 16;230(2):e327-e332. https://doi.org/10.1093/infdis/jiad612

Bibtex

@article{8bd9108dd86d4062979c31f1e53dc63a,
title = "Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans",
abstract = "Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S-specific CD8+ T-cell epitope in an HLA-A*03:01/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction. As evidence from MERS-CoV infection suggests a protective role of long-lasting CD8+ T-cell responses, the identification of epitopes will facilitate longitudinal analyses of vaccine-induced T-cell immunity.",
author = "Harrer, {Caroline E} and Leonie Mayer and Anahita Fathi and Susan Lassen and Ly, {My L} and Zinser, {Madeleine E} and Timo Wolf and Stephan Becker and Gerd Sutter and Christine Dahlke and Addo, {Marylyn M} and {MVA-MERS-S Study Group}",
note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2024",
month = aug,
day = "16",
doi = "10.1093/infdis/jiad612",
language = "English",
volume = "230",
pages = "e327--e332",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Identification of a spike-specific CD8+ T cell epitope following vaccination against the Middle East respiratory syndrome coronavirus in humans

AU - Harrer, Caroline E

AU - Mayer, Leonie

AU - Fathi, Anahita

AU - Lassen, Susan

AU - Ly, My L

AU - Zinser, Madeleine E

AU - Wolf, Timo

AU - Becker, Stephan

AU - Sutter, Gerd

AU - Dahlke, Christine

AU - Addo, Marylyn M

AU - MVA-MERS-S Study Group

N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2024/8/16

Y1 - 2024/8/16

N2 - Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S-specific CD8+ T-cell epitope in an HLA-A*03:01/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction. As evidence from MERS-CoV infection suggests a protective role of long-lasting CD8+ T-cell responses, the identification of epitopes will facilitate longitudinal analyses of vaccine-induced T-cell immunity.

AB - Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S-specific CD8+ T-cell epitope in an HLA-A*03:01/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction. As evidence from MERS-CoV infection suggests a protective role of long-lasting CD8+ T-cell responses, the identification of epitopes will facilitate longitudinal analyses of vaccine-induced T-cell immunity.

U2 - 10.1093/infdis/jiad612

DO - 10.1093/infdis/jiad612

M3 - SCORING: Journal article

C2 - 38195212

VL - 230

SP - e327-e332

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 2

ER -