Research ExplorerPublicationsIdentical lesion morphology in primary progressive and relap...

Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study

Standard

Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study. / Kuchling, Joseph; Ramien, Caren; Bozin, Ivan; Dörr, Jan; Harms, Lutz; Rosche, Berit; Niendorf, Thoralf; Paul, Friedemann; Sinnecker, Tim; Wuerfel, Jens.

In: MULT SCLER J, Vol. 20, No. 14, 12.2014, p. 1866-71.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kuchling, J, Ramien, C, Bozin, I, Dörr, J, Harms, L, Rosche, B, Niendorf, T, Paul, F, Sinnecker, T & Wuerfel, J 2014, 'Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study', MULT SCLER J, vol. 20, no. 14, pp. 1866-71. https://doi.org/10.1177/1352458514531084

APA

Kuchling, J., Ramien, C., Bozin, I., Dörr, J., Harms, L., Rosche, B., Niendorf, T., Paul, F., Sinnecker, T., & Wuerfel, J. (2014). Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study. MULT SCLER J, 20(14), 1866-71. https://doi.org/10.1177/1352458514531084

Vancouver

Kuchling J, Ramien C, Bozin I, Dörr J, Harms L, Rosche B et al. Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study. MULT SCLER J. 2014 Dec;20(14):1866-71. https://doi.org/10.1177/1352458514531084

Bibtex

@article{798a5d1d30bd401e97dc4aa0720f746a,
title = "Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study",
abstract = "Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g., perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.",
keywords = "Adult, Brain/pathology, Cerebral Cortex/pathology, Cohort Studies, Disease Progression, Female, Gray Matter/pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive/pathology, Multiple Sclerosis, Relapsing-Remitting/pathology, White Matter/pathology",
author = "Joseph Kuchling and Caren Ramien and Ivan Bozin and Jan D{\"o}rr and Lutz Harms and Berit Rosche and Thoralf Niendorf and Friedemann Paul and Tim Sinnecker and Jens Wuerfel",
note = "{\textcopyright} The Author(s), 2014.",
year = "2014",
month = dec,
doi = "10.1177/1352458514531084",
language = "English",
volume = "20",
pages = "1866--71",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "14",

}

RIS

TY - JOUR

T1 - Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study

AU - Kuchling, Joseph

AU - Ramien, Caren

AU - Bozin, Ivan

AU - Dörr, Jan

AU - Harms, Lutz

AU - Rosche, Berit

AU - Niendorf, Thoralf

AU - Paul, Friedemann

AU - Sinnecker, Tim

AU - Wuerfel, Jens

N1 - © The Author(s), 2014.

PY - 2014/12

Y1 - 2014/12

N2 - Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g., perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.

AB - Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g., perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.

KW - Adult

KW - Brain/pathology

KW - Cerebral Cortex/pathology

KW - Cohort Studies

KW - Disease Progression

KW - Female

KW - Gray Matter/pathology

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Chronic Progressive/pathology

KW - Multiple Sclerosis, Relapsing-Remitting/pathology

KW - White Matter/pathology

U2 - 10.1177/1352458514531084

DO - 10.1177/1352458514531084

M3 - SCORING: Journal article

C2 - 24781284

VL - 20

SP - 1866

EP - 1871

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 14

ER -