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Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome.

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Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome. / Roedl, Kevin; Spiel, Alexander O; Nürnberger, Alexander; Horvatits, Thomas; Drolz, Andreas; Hubner, Pia; Warenits, Alexandra-Maria; Sterz, Fritz; Herkner, Harald; Fuhrmann, Valentin.

In: RESUSCITATION, Vol. 137, 04.2019, p. 175-182.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Roedl, K, Spiel, AO, Nürnberger, A, Horvatits, T, Drolz, A, Hubner, P, Warenits, A-M, Sterz, F, Herkner, H & Fuhrmann, V 2019, 'Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome.', RESUSCITATION, vol. 137, pp. 175-182. https://doi.org/10.1016/j.resuscitation.2019.02.038

APA

Roedl, K., Spiel, A. O., Nürnberger, A., Horvatits, T., Drolz, A., Hubner, P., Warenits, A-M., Sterz, F., Herkner, H., & Fuhrmann, V. (2019). Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome. RESUSCITATION, 137, 175-182. https://doi.org/10.1016/j.resuscitation.2019.02.038

Vancouver

Roedl K, Spiel AO, Nürnberger A, Horvatits T, Drolz A, Hubner P et al. Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome. RESUSCITATION. 2019 Apr;137:175-182. https://doi.org/10.1016/j.resuscitation.2019.02.038

Bibtex

@article{5f15591960c844fa9842d56f6dee71ca,
title = "Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome.",
abstract = "BACKGROUND: Hypoxic liver injury (HLI) is a frequent and life-threatening complication in critically ill patients that occurs in up to ten percent of critically ill patients. However, there is a lack of data on HLI following cardiac arrest and its clinical implications on outcome. Aim of this study was to investigate incidence, outcome and functional outcome of patients with HLI after in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA).METHODS: We conducted an analysis of a cardiac arrest registry data over a 7-year period. All patients with non-traumatic OHCA and IHCA with return of spontaneous circulation (ROSC) treated at the emergency department of a tertiary care hospital were included in the study. HLI was defined according to established criteria. Predictors of HLI, occurrence, clinical and neurological outcome were assessed using multivariable regression.RESULTS: Out of 1068 patients after IHCA and OHCA with ROSC, 219 (21%) patients developed HLI. Rate of HLI did not differ significantly in IHCA and OHCA patients. Multivariate regression analysis identified time-to-ROSC [OR 1.18, 95% CI (1.01-1.38); p < 0.05], presence of cardiac failure [OR 2.57, 95% CI (1.65-4.01); p < 0.001] and Charlson comorbidity index [OR 0.83, 95% CI (0.72-0.95); p < 0.01] as independent predictors for occurrence of HLI. Good functional outcome was significantly lower in patients suffering from HLI after 28-days (35% vs. 48%, p < 0.001) and 1-year (34% vs. 44%, p < 0.001). Occurrence of HLI was associated with unfavourable neurological outcome [OR 1.74, 95% CI (1.16-2.61); p < 0.01] in multivariate regression analysis.CONCLUSION: New onset of HLI is a frequent finding after IHCA and OHCA. HLI is associated with increased mortality, unfavourable neurological and overall outcome.",
keywords = "Journal Article",
author = "Kevin Roedl and Spiel, {Alexander O} and Alexander N{\"u}rnberger and Thomas Horvatits and Andreas Drolz and Pia Hubner and Alexandra-Maria Warenits and Fritz Sterz and Harald Herkner and Valentin Fuhrmann",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = apr,
doi = "10.1016/j.resuscitation.2019.02.038",
language = "English",
volume = "137",
pages = "175--182",
journal = "RESUSCITATION",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Hypoxic liver injury after in- and out-of-hospital cardiac Arrest: Risk factors and neurological outcome.

AU - Roedl, Kevin

AU - Spiel, Alexander O

AU - Nürnberger, Alexander

AU - Horvatits, Thomas

AU - Drolz, Andreas

AU - Hubner, Pia

AU - Warenits, Alexandra-Maria

AU - Sterz, Fritz

AU - Herkner, Harald

AU - Fuhrmann, Valentin

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: Hypoxic liver injury (HLI) is a frequent and life-threatening complication in critically ill patients that occurs in up to ten percent of critically ill patients. However, there is a lack of data on HLI following cardiac arrest and its clinical implications on outcome. Aim of this study was to investigate incidence, outcome and functional outcome of patients with HLI after in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA).METHODS: We conducted an analysis of a cardiac arrest registry data over a 7-year period. All patients with non-traumatic OHCA and IHCA with return of spontaneous circulation (ROSC) treated at the emergency department of a tertiary care hospital were included in the study. HLI was defined according to established criteria. Predictors of HLI, occurrence, clinical and neurological outcome were assessed using multivariable regression.RESULTS: Out of 1068 patients after IHCA and OHCA with ROSC, 219 (21%) patients developed HLI. Rate of HLI did not differ significantly in IHCA and OHCA patients. Multivariate regression analysis identified time-to-ROSC [OR 1.18, 95% CI (1.01-1.38); p < 0.05], presence of cardiac failure [OR 2.57, 95% CI (1.65-4.01); p < 0.001] and Charlson comorbidity index [OR 0.83, 95% CI (0.72-0.95); p < 0.01] as independent predictors for occurrence of HLI. Good functional outcome was significantly lower in patients suffering from HLI after 28-days (35% vs. 48%, p < 0.001) and 1-year (34% vs. 44%, p < 0.001). Occurrence of HLI was associated with unfavourable neurological outcome [OR 1.74, 95% CI (1.16-2.61); p < 0.01] in multivariate regression analysis.CONCLUSION: New onset of HLI is a frequent finding after IHCA and OHCA. HLI is associated with increased mortality, unfavourable neurological and overall outcome.

AB - BACKGROUND: Hypoxic liver injury (HLI) is a frequent and life-threatening complication in critically ill patients that occurs in up to ten percent of critically ill patients. However, there is a lack of data on HLI following cardiac arrest and its clinical implications on outcome. Aim of this study was to investigate incidence, outcome and functional outcome of patients with HLI after in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA).METHODS: We conducted an analysis of a cardiac arrest registry data over a 7-year period. All patients with non-traumatic OHCA and IHCA with return of spontaneous circulation (ROSC) treated at the emergency department of a tertiary care hospital were included in the study. HLI was defined according to established criteria. Predictors of HLI, occurrence, clinical and neurological outcome were assessed using multivariable regression.RESULTS: Out of 1068 patients after IHCA and OHCA with ROSC, 219 (21%) patients developed HLI. Rate of HLI did not differ significantly in IHCA and OHCA patients. Multivariate regression analysis identified time-to-ROSC [OR 1.18, 95% CI (1.01-1.38); p < 0.05], presence of cardiac failure [OR 2.57, 95% CI (1.65-4.01); p < 0.001] and Charlson comorbidity index [OR 0.83, 95% CI (0.72-0.95); p < 0.01] as independent predictors for occurrence of HLI. Good functional outcome was significantly lower in patients suffering from HLI after 28-days (35% vs. 48%, p < 0.001) and 1-year (34% vs. 44%, p < 0.001). Occurrence of HLI was associated with unfavourable neurological outcome [OR 1.74, 95% CI (1.16-2.61); p < 0.01] in multivariate regression analysis.CONCLUSION: New onset of HLI is a frequent finding after IHCA and OHCA. HLI is associated with increased mortality, unfavourable neurological and overall outcome.

KW - Journal Article

U2 - 10.1016/j.resuscitation.2019.02.038

DO - 10.1016/j.resuscitation.2019.02.038

M3 - SCORING: Journal article

C2 - 30831218

VL - 137

SP - 175

EP - 182

JO - RESUSCITATION

JF - RESUSCITATION

SN - 0300-9572

ER -