Hyperthyroidism in non-seminomatous testicular germ cell tumors
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Hyperthyroidism in non-seminomatous testicular germ cell tumors : two case reports and literature review. / Favero, Diletta; Oing, Christoph; Seidel, Christoph; Rescigno, Pasquale; Catalano, Fabio; Cremante, Malvina; Rebuzzi, Sara Elena; Gatto, Federico; Rosti, Giovanni; Ferone, Diego; Fornarini, Giuseppe; Cocchiara, Francesco.
In: FRONT ONCOL, Vol. 14, 1338438, 2024.Research output: SCORING: Contribution to journal › Case report › Research › peer-review
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TY - JOUR
T1 - Hyperthyroidism in non-seminomatous testicular germ cell tumors
T2 - two case reports and literature review
AU - Favero, Diletta
AU - Oing, Christoph
AU - Seidel, Christoph
AU - Rescigno, Pasquale
AU - Catalano, Fabio
AU - Cremante, Malvina
AU - Rebuzzi, Sara Elena
AU - Gatto, Federico
AU - Rosti, Giovanni
AU - Ferone, Diego
AU - Fornarini, Giuseppe
AU - Cocchiara, Francesco
N1 - Case Report
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Human chorionic gonadotropin (hCG)-induced hyperthyroidism is a rare paraneoplastic syndrome observed in non-seminomatous testicular germ cell tumors, due to a cross-reaction between the β-subunit of hCG with the thyroid-stimulating hormone receptor. The precise prevalence of this paraneoplastic phenomenon is unclear as, in the majority of cases, hyperthyroidism remains subclinical.CASE PRESENTATION: Here, we present two cases of advanced metastatic non-seminomatous testicular germ cell tumors where patients exhibited signs and symptoms of thyrotoxicosis at primary diagnosis due to excessive serum β-hCG elevation, with complete remission of symptomatology after the start of oncological treatments and no signs of relapse at the time of publication of this report. Additionally, we provide a comprehensive review of the existing literature concerning this uncommon occurrence.CONCLUSION: Despite being a rare event, the presence of hyperthyroidism or thyrotoxicosis without clear etiology in a young man should lead to consider less frequent causes such as testicular tumors. Even if patients typically have mild symptoms that resolve after chemotherapy, in rare cases, it can be a life-threatening condition that requires prompt recognition and specific intervention.
AB - BACKGROUND: Human chorionic gonadotropin (hCG)-induced hyperthyroidism is a rare paraneoplastic syndrome observed in non-seminomatous testicular germ cell tumors, due to a cross-reaction between the β-subunit of hCG with the thyroid-stimulating hormone receptor. The precise prevalence of this paraneoplastic phenomenon is unclear as, in the majority of cases, hyperthyroidism remains subclinical.CASE PRESENTATION: Here, we present two cases of advanced metastatic non-seminomatous testicular germ cell tumors where patients exhibited signs and symptoms of thyrotoxicosis at primary diagnosis due to excessive serum β-hCG elevation, with complete remission of symptomatology after the start of oncological treatments and no signs of relapse at the time of publication of this report. Additionally, we provide a comprehensive review of the existing literature concerning this uncommon occurrence.CONCLUSION: Despite being a rare event, the presence of hyperthyroidism or thyrotoxicosis without clear etiology in a young man should lead to consider less frequent causes such as testicular tumors. Even if patients typically have mild symptoms that resolve after chemotherapy, in rare cases, it can be a life-threatening condition that requires prompt recognition and specific intervention.
U2 - 10.3389/fonc.2024.1338438
DO - 10.3389/fonc.2024.1338438
M3 - Case report
C2 - 38601761
VL - 14
JO - FRONT ONCOL
JF - FRONT ONCOL
SN - 2234-943X
M1 - 1338438
ER -
