Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
Standard
Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy. / Daeschlein, Georg; Rutkowski, Rico; Lutze, Stine; von Podewils, Sebastian; Sicher, Claudia; Wild, Thomas; Metelmann, Hans-Robert; von Woedkte, Thomas; Jünger, Michael.
In: BIOMED ENG-BIOMED TE, Vol. 63, No. 5, 25.10.2018, p. 603-608.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Hyperspectral imaging: innovative diagnostics to visualize hemodynamic effects of cold plasma in wound therapy
AU - Daeschlein, Georg
AU - Rutkowski, Rico
AU - Lutze, Stine
AU - von Podewils, Sebastian
AU - Sicher, Claudia
AU - Wild, Thomas
AU - Metelmann, Hans-Robert
AU - von Woedkte, Thomas
AU - Jünger, Michael
PY - 2018/10/25
Y1 - 2018/10/25
N2 - An important clinical potential of cold atmospheric plasma (CAP) lies in tumor and wound treatment, whereby the last-mentioned is well-referenced already. However, the underlying mechanisms of improved wound healing have not been sufficiently clarified yet, in particular the influence of CAP on microcirculation. Hyperspectral imaging (HSI) enables the visualization of microcirculation of large tissue areas, thus this technique seems to be a candidate to examine CAP effects on perfusion and oxygen saturation in wounds. During clinical wound management, one chronic wound caused by peripheral arterial occlusive disease and one acute wound after surgical removal of cervical lymph nodes were examined using HSI before and after CAP treatment. HSI was able to demonstrate CAP effects on microcirculation showing a relevant increase of superficial and deeper cutaneous oxygen saturation together with elevated hemoglobin concentration in treated and also surrounding wound area. For the first time, it was shown that CAP improves the superficial and deeper oxygenation and hemoglobin perfusion in and around the treated area of acute and chronic wounds. This effect may contribute to healing support by CAP in wounds. HSI seems suitable for evaluating and monitoring CAP effects in clinical settings.
AB - An important clinical potential of cold atmospheric plasma (CAP) lies in tumor and wound treatment, whereby the last-mentioned is well-referenced already. However, the underlying mechanisms of improved wound healing have not been sufficiently clarified yet, in particular the influence of CAP on microcirculation. Hyperspectral imaging (HSI) enables the visualization of microcirculation of large tissue areas, thus this technique seems to be a candidate to examine CAP effects on perfusion and oxygen saturation in wounds. During clinical wound management, one chronic wound caused by peripheral arterial occlusive disease and one acute wound after surgical removal of cervical lymph nodes were examined using HSI before and after CAP treatment. HSI was able to demonstrate CAP effects on microcirculation showing a relevant increase of superficial and deeper cutaneous oxygen saturation together with elevated hemoglobin concentration in treated and also surrounding wound area. For the first time, it was shown that CAP improves the superficial and deeper oxygenation and hemoglobin perfusion in and around the treated area of acute and chronic wounds. This effect may contribute to healing support by CAP in wounds. HSI seems suitable for evaluating and monitoring CAP effects in clinical settings.
KW - Hemodynamics
KW - Humans
KW - Microcirculation/physiology
KW - Plasma Gases/chemistry
KW - Skin/diagnostic imaging
KW - Wound Healing/physiology
U2 - 10.1515/bmt-2017-0085
DO - 10.1515/bmt-2017-0085
M3 - SCORING: Journal article
C2 - 29727297
VL - 63
SP - 603
EP - 608
JO - BIOMED ENG-BIOMED TE
JF - BIOMED ENG-BIOMED TE
SN - 0013-5585
IS - 5
ER -