Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study
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Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study. / Haider, Dominik G; Lindner, Gregor; Ahmad, Sufian S; Sauter, Thomas; Wolzt, Michael; Leichtle, Alexander Benedikt; Fiedler, Georg-Martin; Exadaktylos, Aristomenis K; Fuhrmann, Valentin.
In: EUR J INTERN MED, Vol. 26, No. 7, 09.2015, p. 504-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study
AU - Haider, Dominik G
AU - Lindner, Gregor
AU - Ahmad, Sufian S
AU - Sauter, Thomas
AU - Wolzt, Michael
AU - Leichtle, Alexander Benedikt
AU - Fiedler, Georg-Martin
AU - Exadaktylos, Aristomenis K
AU - Fuhrmann, Valentin
N1 - Copyright © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
PY - 2015/9
Y1 - 2015/9
N2 - BACKGROUND: Patients with electrolyte imbalances or disorders have a high risk of mortality. It is unknown if this finding from sodium or potassium disorders extends to alterations of magnesium levels.METHODS AND PATIENTS: In this cross-sectional analysis, all emergency room patients between 2010 and 2011 at the Inselspital Bern, Switzerland, were included. A multivariable logistic regression model was performed to assess the association between magnesium levels and in-hospital mortality up to 28days.RESULTS: A total of 22,239 subjects were screened for the study. A total of 5339 patients had plasma magnesium concentrations measured at hospital admission and were included into the analysis. A total of 6.3% of the 352 patients with hypomagnesemia and 36.9% of the 151 patients with hypermagnesemia died. In a multivariate Cox regression model hypermagnesemia (HR 11.6, p<0.001) was a strong independent risk factor for mortality. In these patients diuretic therapy revealed to be protective (HR 0.5, p=0.007). Hypomagnesemia was not associated with mortality (p>0.05). Age was an independent risk factor for mortality (both p<0.001).CONCLUSION: The study does demonstrate a possible association between hypermagnesemia measured upon admission in the emergency department, and early in-hospital mortality.
AB - BACKGROUND: Patients with electrolyte imbalances or disorders have a high risk of mortality. It is unknown if this finding from sodium or potassium disorders extends to alterations of magnesium levels.METHODS AND PATIENTS: In this cross-sectional analysis, all emergency room patients between 2010 and 2011 at the Inselspital Bern, Switzerland, were included. A multivariable logistic regression model was performed to assess the association between magnesium levels and in-hospital mortality up to 28days.RESULTS: A total of 22,239 subjects were screened for the study. A total of 5339 patients had plasma magnesium concentrations measured at hospital admission and were included into the analysis. A total of 6.3% of the 352 patients with hypomagnesemia and 36.9% of the 151 patients with hypermagnesemia died. In a multivariate Cox regression model hypermagnesemia (HR 11.6, p<0.001) was a strong independent risk factor for mortality. In these patients diuretic therapy revealed to be protective (HR 0.5, p=0.007). Hypomagnesemia was not associated with mortality (p>0.05). Age was an independent risk factor for mortality (both p<0.001).CONCLUSION: The study does demonstrate a possible association between hypermagnesemia measured upon admission in the emergency department, and early in-hospital mortality.
U2 - 10.1016/j.ejim.2015.05.013
DO - 10.1016/j.ejim.2015.05.013
M3 - SCORING: Journal article
C2 - 26049918
VL - 26
SP - 504
EP - 507
JO - EUR J INTERN MED
JF - EUR J INTERN MED
SN - 0953-6205
IS - 7
ER -
