Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Reiner K W Mailer; Anton Gisterå; Konstantinos A Polyzos; Daniel F J Ketelhuth; Göran K Hansson

doi:10.1038/s41598-017-15546-8

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Standard

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. / Mailer, Reiner K W; Gisterå, Anton; Polyzos, Konstantinos A; Ketelhuth, Daniel F J; Hansson, Göran K.

In: SCI REP-UK, Vol. 7, No. 1, 15.11.2017, p. 15655.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mailer, RKW, Gisterå, A, Polyzos, KA, Ketelhuth, DFJ & Hansson, GK 2017, 'Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population', SCI REP-UK, vol. 7, no. 1, pp. 15655. https://doi.org/10.1038/s41598-017-15546-8

APA

Mailer, R. K. W., Gisterå, A., Polyzos, K. A., Ketelhuth, D. F. J., & Hansson, G. K. (2017). Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. SCI REP-UK, 7(1), 15655. https://doi.org/10.1038/s41598-017-15546-8

Vancouver

Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. SCI REP-UK. 2017 Nov 15;7(1):15655. https://doi.org/10.1038/s41598-017-15546-8

Bibtex

@article{ec4a6792e4a643bf81145fc350a0602c,

title = "Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population",

abstract = "Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses.",

keywords = "Journal Article",

author = "Mailer, {Reiner K W} and Anton Gister{\aa} and Polyzos, {Konstantinos A} and Ketelhuth, {Daniel F J} and Hansson, {G{\"o}ran K}",

year = "2017",

month = nov,

day = "15",

doi = "10.1038/s41598-017-15546-8",

language = "English",

volume = "7",

pages = "15655",

journal = "SCI REP-UK",

issn = "2045-2322",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

AU - Mailer, Reiner K W

AU - Gisterå, Anton

AU - Polyzos, Konstantinos A

AU - Ketelhuth, Daniel F J

AU - Hansson, Göran K

PY - 2017/11/15

Y1 - 2017/11/15

N2 - Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses.

AB - Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses.

KW - Journal Article

U2 - 10.1038/s41598-017-15546-8

DO - 10.1038/s41598-017-15546-8

M3 - SCORING: Journal article

C2 - 29142309

VL - 7

SP - 15655

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -