Hydrogel coated and dexamethasone releasing cochlear implantsquantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model
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Hydrogel coated and dexamethasone releasing cochlear implantsquantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model. / Wrzeszcz, Antonina; Steffens, Melanie; Balster, Sven; Warnecke, Athanasia; Dittrich, Barbara; Lenarz, Thomas; Reuter, Günter.
In: J BIOMED MATER RES B, Vol. 103, No. 1, 01.2015, p. 169-78.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hydrogel coated and dexamethasone releasing cochlear implantsquantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model
AU - Wrzeszcz, Antonina
AU - Steffens, Melanie
AU - Balster, Sven
AU - Warnecke, Athanasia
AU - Dittrich, Barbara
AU - Lenarz, Thomas
AU - Reuter, Günter
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2015/1
Y1 - 2015/1
N2 - The insertion of cochlear implants (CIs) often causes fibrous tissue growth around the electrode, which leads to attenuation of function of CIs. Inhibition of fibrosis in vivo using dexamethasone (Dex) released from the implant base material (polydimethylsiloxane [PDMS]) coated with a protein repelling hydrogel (star-shaped polyethylene glycol prepolymer, sPEG) was, therefore, the aim of the study. PDMS filaments with Dex or sPEG were implanted into guinea pigs. The hearing status after implantation did not differ significantly in the treated groups. Using confocal laser scanning microscopy in transparent whole mount preparations, Dex, Dex/sPEG, as well as sPEG showed a tendency toward reduced formation of connective tissue around the implant. To apply such coatings for glass fibers for optical stimulation of the inner ear, insertion forces were measured into a human scala tympani model using fibers with sPEG coating. The results show that the hydrogel did not reduce insertion forces compared to the uncoated samples. However, PDMS-embedded fibers provide comparable insertion forces and depth to those measured with conventional CI electrodes, demonstrating the suitability of laser fibers for a minimal traumatic cochlear implantation.
AB - The insertion of cochlear implants (CIs) often causes fibrous tissue growth around the electrode, which leads to attenuation of function of CIs. Inhibition of fibrosis in vivo using dexamethasone (Dex) released from the implant base material (polydimethylsiloxane [PDMS]) coated with a protein repelling hydrogel (star-shaped polyethylene glycol prepolymer, sPEG) was, therefore, the aim of the study. PDMS filaments with Dex or sPEG were implanted into guinea pigs. The hearing status after implantation did not differ significantly in the treated groups. Using confocal laser scanning microscopy in transparent whole mount preparations, Dex, Dex/sPEG, as well as sPEG showed a tendency toward reduced formation of connective tissue around the implant. To apply such coatings for glass fibers for optical stimulation of the inner ear, insertion forces were measured into a human scala tympani model using fibers with sPEG coating. The results show that the hydrogel did not reduce insertion forces compared to the uncoated samples. However, PDMS-embedded fibers provide comparable insertion forces and depth to those measured with conventional CI electrodes, demonstrating the suitability of laser fibers for a minimal traumatic cochlear implantation.
KW - Animals
KW - Cochlear Implants
KW - Dexamethasone
KW - Dimethylpolysiloxanes
KW - Fibrosis
KW - Guinea Pigs
KW - Humans
KW - Hydrogels
KW - Materials Testing
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/jbm.b.33187
DO - 10.1002/jbm.b.33187
M3 - SCORING: Journal article
C2 - 24811046
VL - 103
SP - 169
EP - 178
JO - J BIOMED MATER RES B
JF - J BIOMED MATER RES B
SN - 1552-4973
IS - 1
ER -
