Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus.
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Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus. / Förster, Eckart; Zhao, S; Frotscher, M.
In: DEVELOPMENT, Vol. 128, No. 15, 15, 2001, p. 3029-3039.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus.
AU - Förster, Eckart
AU - Zhao, S
AU - Frotscher, M
PY - 2001
Y1 - 2001
N2 - In various brain regions, particularly in the hippocampus, afferent fiber projections terminate in specific layers. Little is known about the molecular cues governing this laminar specificity. To this end we have recently shown that the innervation pattern of entorhinal fibers to the hippocampus is mimicked by the lamina-specific adhesion of entorhinal cells on living hippocampal slices, suggesting a role of adhesion molecules in the positioning of entorhinal fibers. Here, we have analyzed the role of extracellular matrix components in mediating this lamina-specific adhesion. We show that hyaluronidase treatment of hippocampal slices abolishes lamina-specific adhesion as well as layer-specific growth of entorhinal fibers to the dentate outer molecular layer in organotypic slice cultures. We conclude that hyaluronan-associated molecules play a crucial role in the formation of the lamina-specific entorhinal projection to the hippocampus.
AB - In various brain regions, particularly in the hippocampus, afferent fiber projections terminate in specific layers. Little is known about the molecular cues governing this laminar specificity. To this end we have recently shown that the innervation pattern of entorhinal fibers to the hippocampus is mimicked by the lamina-specific adhesion of entorhinal cells on living hippocampal slices, suggesting a role of adhesion molecules in the positioning of entorhinal fibers. Here, we have analyzed the role of extracellular matrix components in mediating this lamina-specific adhesion. We show that hyaluronidase treatment of hippocampal slices abolishes lamina-specific adhesion as well as layer-specific growth of entorhinal fibers to the dentate outer molecular layer in organotypic slice cultures. We conclude that hyaluronan-associated molecules play a crucial role in the formation of the lamina-specific entorhinal projection to the hippocampus.
M3 - SCORING: Zeitschriftenaufsatz
VL - 128
SP - 3029
EP - 3039
JO - DEVELOPMENT
JF - DEVELOPMENT
SN - 0950-1991
IS - 15
M1 - 15
ER -
