Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial
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Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial. / Steinke, Sabine; Zeidler, Claudia; Riepe, Claudia; Bruland, Philipp; Soto-Rey, Iñaki; Storck, Michael; Augustin, Matthias; Bobko, Svetlana; Garcovich, Simone; Legat, Franz J; Lvov, Andrey; Misery, Laurent; Osada, Nani; Reich, Adam; Şavk, Ekin; Serra-Baldrich, Esther; Streit, Markus; Szepietowski, Jacek C; Weger, Wolfgang; Dugas, Martin; Ständer, Sonja.
In: J AM ACAD DERMATOL, Vol. 79, No. 3, 09.2018, p. 457-463.e5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial
AU - Steinke, Sabine
AU - Zeidler, Claudia
AU - Riepe, Claudia
AU - Bruland, Philipp
AU - Soto-Rey, Iñaki
AU - Storck, Michael
AU - Augustin, Matthias
AU - Bobko, Svetlana
AU - Garcovich, Simone
AU - Legat, Franz J
AU - Lvov, Andrey
AU - Misery, Laurent
AU - Osada, Nani
AU - Reich, Adam
AU - Şavk, Ekin
AU - Serra-Baldrich, Esther
AU - Streit, Markus
AU - Szepietowski, Jacek C
AU - Weger, Wolfgang
AU - Dugas, Martin
AU - Ständer, Sonja
N1 - Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - BACKGROUND: Chronic pruritus is a multifactorial, challenging symptom of global relevance.OBJECTIVE: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe.METHODS: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL).RESULTS: Duration, frequency, and intensity of pruritus (according to a numeric rating scale and visual analog scale) and related impairment of quality of life differed between European centers and dermatologic diagnoses (P < .05). The country in which the center was located had a greater impact on how patients evaluated pruritus intensity and quality of life than diagnosis did (P < .001).LIMITATIONS: One center per country was included.CONCLUSION: The humanistic burden of chronic pruritus in patients with inflammatory dermatoses is high. European cross-cultural factors may have a stronger influence than a specific dermatologic diagnosis on how patients rate intensity of pruritus and quality of life.
AB - BACKGROUND: Chronic pruritus is a multifactorial, challenging symptom of global relevance.OBJECTIVE: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe.METHODS: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL).RESULTS: Duration, frequency, and intensity of pruritus (according to a numeric rating scale and visual analog scale) and related impairment of quality of life differed between European centers and dermatologic diagnoses (P < .05). The country in which the center was located had a greater impact on how patients evaluated pruritus intensity and quality of life than diagnosis did (P < .001).LIMITATIONS: One center per country was included.CONCLUSION: The humanistic burden of chronic pruritus in patients with inflammatory dermatoses is high. European cross-cultural factors may have a stronger influence than a specific dermatologic diagnosis on how patients rate intensity of pruritus and quality of life.
KW - Adult
KW - Aged
KW - Chronic Disease
KW - Cost of Illness
KW - Cross-Sectional Studies
KW - Dermatitis, Atopic
KW - Dermatitis, Contact
KW - Europe
KW - Female
KW - Humans
KW - Lichen Planus
KW - Male
KW - Middle Aged
KW - Mycosis Fungoides
KW - Prurigo
KW - Pruritus
KW - Psoriasis
KW - Quality of Life
KW - Severity of Illness Index
KW - Journal Article
U2 - 10.1016/j.jaad.2018.04.044
DO - 10.1016/j.jaad.2018.04.044
M3 - SCORING: Journal article
C2 - 30119869
VL - 79
SP - 457-463.e5
JO - J AM ACAD DERMATOL
JF - J AM ACAD DERMATOL
SN - 0190-9622
IS - 3
ER -
