Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002.
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Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002. / de Pedro-Cuesta, Jesús; Glatzel, Markus; Almazán, Javier; Stoeck, Katharina; Mellina, Vittorio; Puopolo, Maria; Pocchiari, Maurizio; Zerr, Inga; Kretszchmar, Hans A; Brandel, Jean-Philippe; Delasnerie-Lauprêtre, Nicole; Alpérovitch, Annick; Cornelia, Van Duijn; Sanchez-Juan, Pascual; Collins, Steven; Lewis, Victoria; Jansen, Gerard H; Coulthart, Michael B; Gelpi, Ellen; Budka, Herbert; Mitrova, Eva.
In: BMC PUBLIC HEALTH, Vol. 6, 2006, p. 278.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002.
AU - de Pedro-Cuesta, Jesús
AU - Glatzel, Markus
AU - Almazán, Javier
AU - Stoeck, Katharina
AU - Mellina, Vittorio
AU - Puopolo, Maria
AU - Pocchiari, Maurizio
AU - Zerr, Inga
AU - Kretszchmar, Hans A
AU - Brandel, Jean-Philippe
AU - Delasnerie-Lauprêtre, Nicole
AU - Alpérovitch, Annick
AU - Cornelia, Van Duijn
AU - Sanchez-Juan, Pascual
AU - Collins, Steven
AU - Lewis, Victoria
AU - Jansen, Gerard H
AU - Coulthart, Michael B
AU - Gelpi, Ellen
AU - Budka, Herbert
AU - Mitrova, Eva
PY - 2006
Y1 - 2006
N2 - BACKGROUND: The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. METHODS: From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993-2002, as well as variations in the use of diagnostic tests. Using logistic models we quantified international differences and changes across time. RESULTS: In general, pre-mortem use of diagnostic investigations increased with time. International differences in pathological confirmation of sporadic Creutzfeldt-Jakob disease, stable over time, were evident. Compared to their counterparts, some countries displayed remarkable patterns, such as: 1) the high proportion, increasing with time, of variant Creutzfeldt-Jakob disease in the United Kingdom, (OR 607.99 95% CI 84.72-4363.40), and France (OR 18.35, 95% CI 2.20-152.83); 2) high, decreasing proportions of iatrogenic Creutzfeldt-Jakob disease in France, (OR 5.81 95% CI 4.09-8.24), and the United Kingdom, (OR 1.54 95% CI 1.03-2.30); and, 3) high and stable ratios of genetic forms in Slovakia (OR 21.82 95% CI 12.42-38.33) and Italy (OR 2.12 95% CI 1.69-2.68). CONCLUSION: Considerable international variation in aetiological subtypes of human transmissible spongiform encephalopathies was evident over the observation period. With the exception of variant Creutzfeldt-Jakob disease and iatrogenic Creutzfeldt-Jakob disease in France and the United Kingdom, these differences persisted across time.
AB - BACKGROUND: The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. METHODS: From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993-2002, as well as variations in the use of diagnostic tests. Using logistic models we quantified international differences and changes across time. RESULTS: In general, pre-mortem use of diagnostic investigations increased with time. International differences in pathological confirmation of sporadic Creutzfeldt-Jakob disease, stable over time, were evident. Compared to their counterparts, some countries displayed remarkable patterns, such as: 1) the high proportion, increasing with time, of variant Creutzfeldt-Jakob disease in the United Kingdom, (OR 607.99 95% CI 84.72-4363.40), and France (OR 18.35, 95% CI 2.20-152.83); 2) high, decreasing proportions of iatrogenic Creutzfeldt-Jakob disease in France, (OR 5.81 95% CI 4.09-8.24), and the United Kingdom, (OR 1.54 95% CI 1.03-2.30); and, 3) high and stable ratios of genetic forms in Slovakia (OR 21.82 95% CI 12.42-38.33) and Italy (OR 2.12 95% CI 1.69-2.68). CONCLUSION: Considerable international variation in aetiological subtypes of human transmissible spongiform encephalopathies was evident over the observation period. With the exception of variant Creutzfeldt-Jakob disease and iatrogenic Creutzfeldt-Jakob disease in France and the United Kingdom, these differences persisted across time.
U2 - 10.1186/1471-2458-6-278
DO - 10.1186/1471-2458-6-278
M3 - SCORING: Zeitschriftenaufsatz
VL - 6
SP - 278
JO - BMC PUBLIC HEALTH
JF - BMC PUBLIC HEALTH
SN - 1471-2458
ER -
