Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. / Guadalupe, Tulio; Mathias, Samuel R; vanErp, Theo G M; Whelan, Christopher D; Zwiers, Marcel P; Abe, Yoshinari; Abramovic, Lucija; Agartz, Ingrid; Andreassen, Ole A; Arias-Vásquez, Alejandro; Aribisala, Benjamin S; Armstrong, Nicola J; Arolt, Volker; Artiges, Eric; Ayesa-Arriola, Rosa; Baboyan, Vatche G; Banaschewski, Tobias; Barker, Gareth; Bastin, Mark E; Baune, Bernhard T; Blangero, John; Bokde, Arun L W; Boedhoe, Premika S W; Bose, Anushree; Brem, Silvia; Brodaty, Henry; Bromberg, Uli; Brooks, Samantha; Büchel, Christian; Buitelaar, Jan; Calhoun, Vince D; Cannon, Dara M; Cattrell, Anna; Cheng, Yuqi; Conrod, Patricia J; Conzelmann, Annette; Corvin, Aiden; Crespo-Facorro, Benedicto; Crivello, Fabrice; Dannlowski, Udo; de Zubicaray, Greig I; de Zwarte, Sonja M C; Deary, Ian J; Desrivières, Sylvane; Doan, Nhat Trung; Donohoe, Gary; Dørum, Erlend S; Ehrlich, Stefan; Espeseth, Thomas; Fernández, Guillén; Flor, Herta; Fouche, Jean-Paul; Frouin, Vincent; Fukunaga, Masaki; Gallinat, Jürgen; Garavan, Hugh; Gill, Michael; Suarez, Andrea Gonzalez; Gowland, Penny; Grabe, Hans J; Grotegerd, Dominik; Gruber, Oliver; Hagenaars, Saskia; Hashimoto, Ryota; Hauser, Tobias U; Heinz, Andreas; Hibar, Derrek P; Hoekstra, Pieter J; Hoogman, Martine; Howells, Fleur M; Hu, Hao; Hulshoff Pol, Hilleke E; Huyser, Chaim; Ittermann, Bernd; Jahanshad, Neda; Jönsson, Erik G; Jurk, Sarah; Kahn, Rene S; Kelly, Sinead; Kraemer, Bernd; Kugel, Harald; Kwon, Jun Soo; Lemaitre, Herve; Lesch, Klaus-Peter; Lochner, Christine; Luciano, Michelle; Marquand, Andre F; Martin, Nicholas G; Martínez-Zalacaín, Ignacio; Martinot, Jean-Luc; Mataix-Cols, David; Mather, Karen; McDonald, Colm; McMahon, Katie L; Medland, Sarah E; Menchón, José M; Morris, Derek W; Mothersill, Omar; Maniega, Susana Munoz; Mwangi, Benson; Nakamae, Takashi; Nakao, Tomohiro; Narayanaswaamy, Janardhanan C; Nees, Frauke; Nordvik, Jan E; Onnink, A Marten H; Opel, Nils; Ophoff, Roel; Paillère Martinot, Marie-Laure; Papadopoulos Orfanos, Dimitri; Pauli, Paul; Paus, Tomáš; Poustka, Luise; Reddy, Janardhan Yc; Renteria, Miguel E; Roiz-Santiáñez, Roberto; Roos, Annerine; Royle, Natalie A; Sachdev, Perminder; Sánchez-Juan, Pascual; Schmaal, Lianne; Schumann, Gunter; Shumskaya, Elena; Smolka, Michael N; Soares, Jair C; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Toro, Roberto; Turner, Jessica A; Tzourio-Mazoyer, Nathalie; Uhlmann, Anne; Hernández, Maria Valdés; van den Heuvel, Odile A; van der Meer, Dennis; van Haren, Neeltje E M; Veltman, Dick J; Venkatasubramanian, Ganesan; Vetter, Nora C; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wang, Zhen; Wardlaw, Joanna; Wen, Wei; Westlye, Lars T; Whelan, Robert; Wittfeld, Katharina; Wolfers, Thomas; Wright, Margaret J; Xu, Jian; Xu, Xiufeng; Yun, Je-Yeon; Zhao, JingJing; Franke, Barbara; Thompson, Paul M; Glahn, David C; Mazoyer, Bernard; Fisher, Simon E; Francks, Clyde.
In: BRAIN IMAGING BEHAV, Vol. 11, No. 5, 10.2017, p. 1497-1514.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
AU - Guadalupe, Tulio
AU - Mathias, Samuel R
AU - vanErp, Theo G M
AU - Whelan, Christopher D
AU - Zwiers, Marcel P
AU - Abe, Yoshinari
AU - Abramovic, Lucija
AU - Agartz, Ingrid
AU - Andreassen, Ole A
AU - Arias-Vásquez, Alejandro
AU - Aribisala, Benjamin S
AU - Armstrong, Nicola J
AU - Arolt, Volker
AU - Artiges, Eric
AU - Ayesa-Arriola, Rosa
AU - Baboyan, Vatche G
AU - Banaschewski, Tobias
AU - Barker, Gareth
AU - Bastin, Mark E
AU - Baune, Bernhard T
AU - Blangero, John
AU - Bokde, Arun L W
AU - Boedhoe, Premika S W
AU - Bose, Anushree
AU - Brem, Silvia
AU - Brodaty, Henry
AU - Bromberg, Uli
AU - Brooks, Samantha
AU - Büchel, Christian
AU - Buitelaar, Jan
AU - Calhoun, Vince D
AU - Cannon, Dara M
AU - Cattrell, Anna
AU - Cheng, Yuqi
AU - Conrod, Patricia J
AU - Conzelmann, Annette
AU - Corvin, Aiden
AU - Crespo-Facorro, Benedicto
AU - Crivello, Fabrice
AU - Dannlowski, Udo
AU - de Zubicaray, Greig I
AU - de Zwarte, Sonja M C
AU - Deary, Ian J
AU - Desrivières, Sylvane
AU - Doan, Nhat Trung
AU - Donohoe, Gary
AU - Dørum, Erlend S
AU - Ehrlich, Stefan
AU - Espeseth, Thomas
AU - Fernández, Guillén
AU - Flor, Herta
AU - Fouche, Jean-Paul
AU - Frouin, Vincent
AU - Fukunaga, Masaki
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gill, Michael
AU - Suarez, Andrea Gonzalez
AU - Gowland, Penny
AU - Grabe, Hans J
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Hagenaars, Saskia
AU - Hashimoto, Ryota
AU - Hauser, Tobias U
AU - Heinz, Andreas
AU - Hibar, Derrek P
AU - Hoekstra, Pieter J
AU - Hoogman, Martine
AU - Howells, Fleur M
AU - Hu, Hao
AU - Hulshoff Pol, Hilleke E
AU - Huyser, Chaim
AU - Ittermann, Bernd
AU - Jahanshad, Neda
AU - Jönsson, Erik G
AU - Jurk, Sarah
AU - Kahn, Rene S
AU - Kelly, Sinead
AU - Kraemer, Bernd
AU - Kugel, Harald
AU - Kwon, Jun Soo
AU - Lemaitre, Herve
AU - Lesch, Klaus-Peter
AU - Lochner, Christine
AU - Luciano, Michelle
AU - Marquand, Andre F
AU - Martin, Nicholas G
AU - Martínez-Zalacaín, Ignacio
AU - Martinot, Jean-Luc
AU - Mataix-Cols, David
AU - Mather, Karen
AU - McDonald, Colm
AU - McMahon, Katie L
AU - Medland, Sarah E
AU - Menchón, José M
AU - Morris, Derek W
AU - Mothersill, Omar
AU - Maniega, Susana Munoz
AU - Mwangi, Benson
AU - Nakamae, Takashi
AU - Nakao, Tomohiro
AU - Narayanaswaamy, Janardhanan C
AU - Nees, Frauke
AU - Nordvik, Jan E
AU - Onnink, A Marten H
AU - Opel, Nils
AU - Ophoff, Roel
AU - Paillère Martinot, Marie-Laure
AU - Papadopoulos Orfanos, Dimitri
AU - Pauli, Paul
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Reddy, Janardhan Yc
AU - Renteria, Miguel E
AU - Roiz-Santiáñez, Roberto
AU - Roos, Annerine
AU - Royle, Natalie A
AU - Sachdev, Perminder
AU - Sánchez-Juan, Pascual
AU - Schmaal, Lianne
AU - Schumann, Gunter
AU - Shumskaya, Elena
AU - Smolka, Michael N
AU - Soares, Jair C
AU - Soriano-Mas, Carles
AU - Stein, Dan J
AU - Strike, Lachlan T
AU - Toro, Roberto
AU - Turner, Jessica A
AU - Tzourio-Mazoyer, Nathalie
AU - Uhlmann, Anne
AU - Hernández, Maria Valdés
AU - van den Heuvel, Odile A
AU - van der Meer, Dennis
AU - van Haren, Neeltje E M
AU - Veltman, Dick J
AU - Venkatasubramanian, Ganesan
AU - Vetter, Nora C
AU - Vuletic, Daniella
AU - Walitza, Susanne
AU - Walter, Henrik
AU - Walton, Esther
AU - Wang, Zhen
AU - Wardlaw, Joanna
AU - Wen, Wei
AU - Westlye, Lars T
AU - Whelan, Robert
AU - Wittfeld, Katharina
AU - Wolfers, Thomas
AU - Wright, Margaret J
AU - Xu, Jian
AU - Xu, Xiufeng
AU - Yun, Je-Yeon
AU - Zhao, JingJing
AU - Franke, Barbara
AU - Thompson, Paul M
AU - Glahn, David C
AU - Mazoyer, Bernard
AU - Fisher, Simon E
AU - Francks, Clyde
PY - 2017/10
Y1 - 2017/10
N2 - The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
AB - The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
U2 - 10.1007/s11682-016-9629-z
DO - 10.1007/s11682-016-9629-z
M3 - SCORING: Journal article
C2 - 27738994
VL - 11
SP - 1497
EP - 1514
JO - BRAIN IMAGING BEHAV
JF - BRAIN IMAGING BEHAV
SN - 1931-7557
IS - 5
ER -
