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Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens.

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Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens. / Henke, R P; Milde-Langosch, K; Löning, T; Koppang, H S.

In: Virchows Arch A Pathol Anat Histopathol, Vol. 411, No. 2, 2, 1987, p. 193-198.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Henke, RP, Milde-Langosch, K, Löning, T & Koppang, HS 1987, 'Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens.', Virchows Arch A Pathol Anat Histopathol, vol. 411, no. 2, 2, pp. 193-198. <http://www.ncbi.nlm.nih.gov/pubmed/3037771?dopt=Citation>

APA

Henke, R. P., Milde-Langosch, K., Löning, T., & Koppang, H. S. (1987). Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens. Virchows Arch A Pathol Anat Histopathol, 411(2), 193-198. [2]. http://www.ncbi.nlm.nih.gov/pubmed/3037771?dopt=Citation

Vancouver

Henke RP, Milde-Langosch K, Löning T, Koppang HS. Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens. Virchows Arch A Pathol Anat Histopathol. 1987;411(2):193-198. 2.

Bibtex

@article{bcfb842c73cc49af85c832f2024a4bb1,
title = "Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens.",
abstract = "16 cases of focal epithelial hyperplasia (Heck's disease) were studied for the presence of human papillomavirus DNA by means of nucleic acid hybridization. Hybridization was carried out in situ with biotin-labelled probes of HPV 1, 6, 11, 13, 16, and 18 DNA under stringent and non-stringent conditions. Under non-stringent conditions, 6 of 16 cases (38%) hybridized to a mixture of HPV 1, 6, 11, 16, and 18 DNA. When these probes were applied under stringent conditions, only one case could be shown to be weakly positive for HPV 6/11 DNA. Further stringent hybridizations, which were conducted with a HPV 13 probe on 12 of our 16 cases, revealed a positive result in 9 of 12 cases (75%). The results of our study strongly substantiate the concept that HPV 13 or a closely related HPV type is associated with lesions morphologically presenting as focal epithelial hyperplasia.",
keywords = "Adult, Aged, DNA, Viral, Epithelium, Female, Histological Techniques, Humans, Hyperplasia, Male, Middle Aged, Mouth Mucosa, Nucleic Acid Hybridization, Papillomaviridae",
author = "Henke, {R P} and K Milde-Langosch and T L{\"o}ning and Koppang, {H S}",
year = "1987",
language = "English",
volume = "411",
pages = "193--198",
journal = "VIRCHOWS ARCH",
issn = "0945-6317",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens.

AU - Henke, R P

AU - Milde-Langosch, K

AU - Löning, T

AU - Koppang, H S

PY - 1987

Y1 - 1987

N2 - 16 cases of focal epithelial hyperplasia (Heck's disease) were studied for the presence of human papillomavirus DNA by means of nucleic acid hybridization. Hybridization was carried out in situ with biotin-labelled probes of HPV 1, 6, 11, 13, 16, and 18 DNA under stringent and non-stringent conditions. Under non-stringent conditions, 6 of 16 cases (38%) hybridized to a mixture of HPV 1, 6, 11, 16, and 18 DNA. When these probes were applied under stringent conditions, only one case could be shown to be weakly positive for HPV 6/11 DNA. Further stringent hybridizations, which were conducted with a HPV 13 probe on 12 of our 16 cases, revealed a positive result in 9 of 12 cases (75%). The results of our study strongly substantiate the concept that HPV 13 or a closely related HPV type is associated with lesions morphologically presenting as focal epithelial hyperplasia.

AB - 16 cases of focal epithelial hyperplasia (Heck's disease) were studied for the presence of human papillomavirus DNA by means of nucleic acid hybridization. Hybridization was carried out in situ with biotin-labelled probes of HPV 1, 6, 11, 13, 16, and 18 DNA under stringent and non-stringent conditions. Under non-stringent conditions, 6 of 16 cases (38%) hybridized to a mixture of HPV 1, 6, 11, 16, and 18 DNA. When these probes were applied under stringent conditions, only one case could be shown to be weakly positive for HPV 6/11 DNA. Further stringent hybridizations, which were conducted with a HPV 13 probe on 12 of our 16 cases, revealed a positive result in 9 of 12 cases (75%). The results of our study strongly substantiate the concept that HPV 13 or a closely related HPV type is associated with lesions morphologically presenting as focal epithelial hyperplasia.

KW - Adult

KW - Aged

KW - DNA, Viral

KW - Epithelium

KW - Female

KW - Histological Techniques

KW - Humans

KW - Hyperplasia

KW - Male

KW - Middle Aged

KW - Mouth Mucosa

KW - Nucleic Acid Hybridization

KW - Papillomaviridae

M3 - SCORING: Journal article

C2 - 3037771

VL - 411

SP - 193

EP - 198

JO - VIRCHOWS ARCH

JF - VIRCHOWS ARCH

SN - 0945-6317

IS - 2

M1 - 2

ER -