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Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection

Standard

Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. / Beitzen-Heineke, Antonia; Bouzani, Maria; Schmitt, Anna-Lena; Kurzai, Oliver; Hünniger, Kerstin; Einsele, Hermann; Loeffler, Juergen.

In: MED MYCOL, Vol. 54, No. 2, 18.10.2015, p. 169-176.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beitzen-Heineke, A, Bouzani, M, Schmitt, A-L, Kurzai, O, Hünniger, K, Einsele, H & Loeffler, J 2015, 'Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection', MED MYCOL, vol. 54, no. 2, pp. 169-176. https://doi.org/10.1093/mmy/myv074

APA

Beitzen-Heineke, A., Bouzani, M., Schmitt, A-L., Kurzai, O., Hünniger, K., Einsele, H., & Loeffler, J. (2015). Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. MED MYCOL, 54(2), 169-176. https://doi.org/10.1093/mmy/myv074

Vancouver

Beitzen-Heineke A, Bouzani M, Schmitt A-L, Kurzai O, Hünniger K, Einsele H et al. Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. MED MYCOL. 2015 Oct 18;54(2):169-176. https://doi.org/10.1093/mmy/myv074

Bibtex

@article{8c3bab8494624678bb885ffd5f309992,
title = "Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection",
abstract = "Aspergillus fumigatus is the most common cause for invasive fungal infections, a disease associated with high mortality in immune-compromised patients. CD1d-restricted invariant natural killer T (iNKT) cells compose a small subset of T cells known to impact the immune response toward various infectious pathogens. To investigate the role of human iNKT cells during A. fumigatus infection, we studied their activation as determined by CD69 expression and cytokine production in response to distinct fungal morphotypes in the presence of different CD1d(+) antigen presenting cells using flow cytometry and multiplex enzyme-linked immunosorbent assay (ELISA). Among CD1d(+) subpopulations, CD1d(+)CD1c(+) mDCs showed the highest potential to activate iNKT cells on a per cell basis. The presence of A. fumigatus decreased this effect of CD1d(+)CD1c(+) mDCs on iNKT cells and led to reduced secretion of TNF-α, G-CSF and RANTES. Production of other Th1 and Th2 cytokines was not affected by the fungus, suggesting an immune-modulating function for human iNKT cells during A. fumigatus infection.",
author = "Antonia Beitzen-Heineke and Maria Bouzani and Anna-Lena Schmitt and Oliver Kurzai and Kerstin H{\"u}nniger and Hermann Einsele and Juergen Loeffler",
note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2015",
month = oct,
day = "18",
doi = "10.1093/mmy/myv074",
language = "English",
volume = "54",
pages = "169--176",
journal = "MED MYCOL",
issn = "1369-3786",
publisher = "informa healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection

AU - Beitzen-Heineke, Antonia

AU - Bouzani, Maria

AU - Schmitt, Anna-Lena

AU - Kurzai, Oliver

AU - Hünniger, Kerstin

AU - Einsele, Hermann

AU - Loeffler, Juergen

N1 - © The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/10/18

Y1 - 2015/10/18

N2 - Aspergillus fumigatus is the most common cause for invasive fungal infections, a disease associated with high mortality in immune-compromised patients. CD1d-restricted invariant natural killer T (iNKT) cells compose a small subset of T cells known to impact the immune response toward various infectious pathogens. To investigate the role of human iNKT cells during A. fumigatus infection, we studied their activation as determined by CD69 expression and cytokine production in response to distinct fungal morphotypes in the presence of different CD1d(+) antigen presenting cells using flow cytometry and multiplex enzyme-linked immunosorbent assay (ELISA). Among CD1d(+) subpopulations, CD1d(+)CD1c(+) mDCs showed the highest potential to activate iNKT cells on a per cell basis. The presence of A. fumigatus decreased this effect of CD1d(+)CD1c(+) mDCs on iNKT cells and led to reduced secretion of TNF-α, G-CSF and RANTES. Production of other Th1 and Th2 cytokines was not affected by the fungus, suggesting an immune-modulating function for human iNKT cells during A. fumigatus infection.

AB - Aspergillus fumigatus is the most common cause for invasive fungal infections, a disease associated with high mortality in immune-compromised patients. CD1d-restricted invariant natural killer T (iNKT) cells compose a small subset of T cells known to impact the immune response toward various infectious pathogens. To investigate the role of human iNKT cells during A. fumigatus infection, we studied their activation as determined by CD69 expression and cytokine production in response to distinct fungal morphotypes in the presence of different CD1d(+) antigen presenting cells using flow cytometry and multiplex enzyme-linked immunosorbent assay (ELISA). Among CD1d(+) subpopulations, CD1d(+)CD1c(+) mDCs showed the highest potential to activate iNKT cells on a per cell basis. The presence of A. fumigatus decreased this effect of CD1d(+)CD1c(+) mDCs on iNKT cells and led to reduced secretion of TNF-α, G-CSF and RANTES. Production of other Th1 and Th2 cytokines was not affected by the fungus, suggesting an immune-modulating function for human iNKT cells during A. fumigatus infection.

U2 - 10.1093/mmy/myv074

DO - 10.1093/mmy/myv074

M3 - SCORING: Journal article

C2 - 26483428

VL - 54

SP - 169

EP - 176

JO - MED MYCOL

JF - MED MYCOL

SN - 1369-3786

IS - 2

ER -