Human hepatitis D virus-specific T cell epitopes
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Human hepatitis D virus-specific T cell epitopes. / Kohsar, Matin; Landahl, Johanna; Neumann-Haefelin, Christoph; Schulze Zur Wiesch, Julian.
In: JHEP REP, Vol. 3, No. 4, 08.2021, p. 100294.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Human hepatitis D virus-specific T cell epitopes
AU - Kohsar, Matin
AU - Landahl, Johanna
AU - Neumann-Haefelin, Christoph
AU - Schulze Zur Wiesch, Julian
N1 - © 2021 The Authors.
PY - 2021/8
Y1 - 2021/8
N2 - HDV is a small, defective RNA virus that requires the HBsAg of HBV for its assembly, release, and transmission. Chronic HBV/HDV infection often has a severe clinical outcome and is difficult to treat. The important role of a robust virus-specific T cell response for natural viral control has been established for many other chronic viral infections, but the exact role of the T cell response in the control and progression of chronic HDV infection is far less clear. Several recent studies have characterised HDV-specific CD4+ and CD8+ T cell responses on a peptide level. This review comprehensively summarises all HDV-specific T cell epitopes described to date and describes our current knowledge of the role of T cells in HDV infection. While we now have better tools to study the adaptive anti-HDV-specific T cell response, further efforts are needed to define the HLA restriction of additional HDV-specific T cell epitopes, establish additional HDV-specific MHC tetramers, understand the degree of cross HDV genotype reactivity of individual epitopes and understand the correlation of the HBV- and HDV-specific T cell response, as well as the breadth and specificity of the intrahepatic HDV-specific T cell response.
AB - HDV is a small, defective RNA virus that requires the HBsAg of HBV for its assembly, release, and transmission. Chronic HBV/HDV infection often has a severe clinical outcome and is difficult to treat. The important role of a robust virus-specific T cell response for natural viral control has been established for many other chronic viral infections, but the exact role of the T cell response in the control and progression of chronic HDV infection is far less clear. Several recent studies have characterised HDV-specific CD4+ and CD8+ T cell responses on a peptide level. This review comprehensively summarises all HDV-specific T cell epitopes described to date and describes our current knowledge of the role of T cells in HDV infection. While we now have better tools to study the adaptive anti-HDV-specific T cell response, further efforts are needed to define the HLA restriction of additional HDV-specific T cell epitopes, establish additional HDV-specific MHC tetramers, understand the degree of cross HDV genotype reactivity of individual epitopes and understand the correlation of the HBV- and HDV-specific T cell response, as well as the breadth and specificity of the intrahepatic HDV-specific T cell response.
U2 - 10.1016/j.jhepr.2021.100294
DO - 10.1016/j.jhepr.2021.100294
M3 - SCORING: Review article
C2 - 34308324
VL - 3
SP - 100294
JO - JHEP REP
JF - JHEP REP
SN - 2589-5559
IS - 4
ER -