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Human cytomegalovirus replication induces endothelial cell interleukin-11

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Human cytomegalovirus replication induces endothelial cell interleukin-11. / Gustafsson, K L R; Renné, T; Söderberg-Naucler, C; Butler, L M.

In: CYTOKINE, Vol. 111, 11.2018, p. 563-566.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gustafsson, KLR, Renné, T, Söderberg-Naucler, C & Butler, LM 2018, 'Human cytomegalovirus replication induces endothelial cell interleukin-11', CYTOKINE, vol. 111, pp. 563-566. https://doi.org/10.1016/j.cyto.2018.05.018

APA

Gustafsson, K. L. R., Renné, T., Söderberg-Naucler, C., & Butler, L. M. (2018). Human cytomegalovirus replication induces endothelial cell interleukin-11. CYTOKINE, 111, 563-566. https://doi.org/10.1016/j.cyto.2018.05.018

Vancouver

Gustafsson KLR, Renné T, Söderberg-Naucler C, Butler LM. Human cytomegalovirus replication induces endothelial cell interleukin-11. CYTOKINE. 2018 Nov;111:563-566. https://doi.org/10.1016/j.cyto.2018.05.018

Bibtex

@article{2b5f3cbdc66d45ec964a2c8f346000aa,
title = "Human cytomegalovirus replication induces endothelial cell interleukin-11",
abstract = "Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.",
keywords = "Journal Article",
author = "Gustafsson, {K L R} and T Renn{\'e} and C S{\"o}derberg-Naucler and Butler, {L M}",
note = "Document Type: Short Communication",
year = "2018",
month = nov,
doi = "10.1016/j.cyto.2018.05.018",
language = "English",
volume = "111",
pages = "563--566",
journal = "CYTOKINE",
issn = "1043-4666",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Human cytomegalovirus replication induces endothelial cell interleukin-11

AU - Gustafsson, K L R

AU - Renné, T

AU - Söderberg-Naucler, C

AU - Butler, L M

N1 - Document Type: Short Communication

PY - 2018/11

Y1 - 2018/11

N2 - Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.

AB - Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.

KW - Journal Article

U2 - 10.1016/j.cyto.2018.05.018

DO - 10.1016/j.cyto.2018.05.018

M3 - SCORING: Journal article

C2 - 29807687

VL - 111

SP - 563

EP - 566

JO - CYTOKINE

JF - CYTOKINE

SN - 1043-4666

ER -