Research ExplorerPublicationsHuman cardiac organoids to model COVID-19 cytokine storm ind...

Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries

Standard

Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. / Arhontoulis, Dimitrios C; Kerr, Charles M; Richards, Dylan; Tjen, Kelsey; Hyams, Nathaniel; Jones, Jefferey A; Deleon-Pennell, Kristine; Menick, Donald; Bräuninger, Hanna; Lindner, Diana; Westermann, Dirk; Mei, Ying.

In: J TISSUE ENG REGEN M, Vol. 16, No. 9, 09.2022, p. 799-811.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Arhontoulis, DC, Kerr, CM, Richards, D, Tjen, K, Hyams, N, Jones, JA, Deleon-Pennell, K, Menick, D, Bräuninger, H, Lindner, D, Westermann, D & Mei, Y 2022, 'Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries', J TISSUE ENG REGEN M, vol. 16, no. 9, pp. 799-811. https://doi.org/10.1002/term.3327

APA

Arhontoulis, D. C., Kerr, C. M., Richards, D., Tjen, K., Hyams, N., Jones, J. A., Deleon-Pennell, K., Menick, D., Bräuninger, H., Lindner, D., Westermann, D., & Mei, Y. (2022). Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. J TISSUE ENG REGEN M, 16(9), 799-811. https://doi.org/10.1002/term.3327

Vancouver

Arhontoulis DC, Kerr CM, Richards D, Tjen K, Hyams N, Jones JA et al. Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. J TISSUE ENG REGEN M. 2022 Sep;16(9):799-811. https://doi.org/10.1002/term.3327

Bibtex

@article{ed132269cf354c61b863126d59ae3917,
title = "Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries",
abstract = "Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.",
keywords = "COVID-19/complications, Cytokine Release Syndrome/virology, Cytokines/metabolism, Heart Diseases/virology, Humans, Models, Biological, Organoids",
author = "Arhontoulis, {Dimitrios C} and Kerr, {Charles M} and Dylan Richards and Kelsey Tjen and Nathaniel Hyams and Jones, {Jefferey A} and Kristine Deleon-Pennell and Donald Menick and Hanna Br{\"a}uninger and Diana Lindner and Dirk Westermann and Ying Mei",
note = "{\textcopyright} 2022 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd.",
year = "2022",
month = sep,
doi = "10.1002/term.3327",
language = "English",
volume = "16",
pages = "799--811",
journal = "J TISSUE ENG REGEN M",
issn = "1932-6254",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries

AU - Arhontoulis, Dimitrios C

AU - Kerr, Charles M

AU - Richards, Dylan

AU - Tjen, Kelsey

AU - Hyams, Nathaniel

AU - Jones, Jefferey A

AU - Deleon-Pennell, Kristine

AU - Menick, Donald

AU - Bräuninger, Hanna

AU - Lindner, Diana

AU - Westermann, Dirk

AU - Mei, Ying

N1 - © 2022 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd.

PY - 2022/9

Y1 - 2022/9

N2 - Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.

AB - Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.

KW - COVID-19/complications

KW - Cytokine Release Syndrome/virology

KW - Cytokines/metabolism

KW - Heart Diseases/virology

KW - Humans

KW - Models, Biological

KW - Organoids

U2 - 10.1002/term.3327

DO - 10.1002/term.3327

M3 - SCORING: Journal article

C2 - 35689600

VL - 16

SP - 799

EP - 811

JO - J TISSUE ENG REGEN M

JF - J TISSUE ENG REGEN M

SN - 1932-6254

IS - 9

ER -