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Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

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Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. / de Jong, Jasper M A; Sun, Wenfei; Pires, Nuno D; Frontini, Andrea; Balaz, Miroslav; Jespersen, Naja Z; Feizi, Amir; Petrovic, Katarina; Fischer, Alexander W; Bokhari, Muhammad Hamza; Niemi, Tarja; Nuutila, Pirjo; Cinti, Saverio; Nielsen, Søren; Scheele, Camilla; Virtanen, Kirsi; Cannon, Barbara; Nedergaard, Jan; Wolfrum, Christian; Petrovic, Natasa.

In: NAT METAB, Vol. 1, No. 8, 08.2019, p. 830-843.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

de Jong, JMA, Sun, W, Pires, ND, Frontini, A, Balaz, M, Jespersen, NZ, Feizi, A, Petrovic, K, Fischer, AW, Bokhari, MH, Niemi, T, Nuutila, P, Cinti, S, Nielsen, S, Scheele, C, Virtanen, K, Cannon, B, Nedergaard, J, Wolfrum, C & Petrovic, N 2019, 'Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice', NAT METAB, vol. 1, no. 8, pp. 830-843. https://doi.org/10.1038/s42255-019-0101-4

APA

de Jong, J. M. A., Sun, W., Pires, N. D., Frontini, A., Balaz, M., Jespersen, N. Z., Feizi, A., Petrovic, K., Fischer, A. W., Bokhari, M. H., Niemi, T., Nuutila, P., Cinti, S., Nielsen, S., Scheele, C., Virtanen, K., Cannon, B., Nedergaard, J., Wolfrum, C., & Petrovic, N. (2019). Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. NAT METAB, 1(8), 830-843. https://doi.org/10.1038/s42255-019-0101-4

Vancouver

de Jong JMA, Sun W, Pires ND, Frontini A, Balaz M, Jespersen NZ et al. Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. NAT METAB. 2019 Aug;1(8):830-843. https://doi.org/10.1038/s42255-019-0101-4

Bibtex

@article{a6cb246705234f6295768e085527dd41,
title = "Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice",
abstract = "Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 °C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.",
keywords = "Adipose Tissue, Brown/physiology, Animals, Humans, Mice, Thermogenesis",
author = "{de Jong}, {Jasper M A} and Wenfei Sun and Pires, {Nuno D} and Andrea Frontini and Miroslav Balaz and Jespersen, {Naja Z} and Amir Feizi and Katarina Petrovic and Fischer, {Alexander W} and Bokhari, {Muhammad Hamza} and Tarja Niemi and Pirjo Nuutila and Saverio Cinti and S{\o}ren Nielsen and Camilla Scheele and Kirsi Virtanen and Barbara Cannon and Jan Nedergaard and Christian Wolfrum and Natasa Petrovic",
year = "2019",
month = aug,
doi = "10.1038/s42255-019-0101-4",
language = "English",
volume = "1",
pages = "830--843",
journal = "NAT METAB",
issn = "2522-5812",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

AU - de Jong, Jasper M A

AU - Sun, Wenfei

AU - Pires, Nuno D

AU - Frontini, Andrea

AU - Balaz, Miroslav

AU - Jespersen, Naja Z

AU - Feizi, Amir

AU - Petrovic, Katarina

AU - Fischer, Alexander W

AU - Bokhari, Muhammad Hamza

AU - Niemi, Tarja

AU - Nuutila, Pirjo

AU - Cinti, Saverio

AU - Nielsen, Søren

AU - Scheele, Camilla

AU - Virtanen, Kirsi

AU - Cannon, Barbara

AU - Nedergaard, Jan

AU - Wolfrum, Christian

AU - Petrovic, Natasa

PY - 2019/8

Y1 - 2019/8

N2 - Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 °C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.

AB - Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 °C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.

KW - Adipose Tissue, Brown/physiology

KW - Animals

KW - Humans

KW - Mice

KW - Thermogenesis

U2 - 10.1038/s42255-019-0101-4

DO - 10.1038/s42255-019-0101-4

M3 - SCORING: Journal article

C2 - 32694768

VL - 1

SP - 830

EP - 843

JO - NAT METAB

JF - NAT METAB

SN - 2522-5812

IS - 8

ER -