Research ExplorerPublicationsHorizontal Aorta in Transcatheter Self-Expanding Valves: Ins...

Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry

Standard

Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry. / Gallo, Francesco; Gallone, Guglielmo; Kim, Won-Keun; Reifart, Jörg; Veulemans, Verena; Zeus, Tobias; Toggweiler, Stefan; De Backer, Ole; Søndergaard, Lars; Mangieri, Antonio; Khokhar, Arif; De Marco, Federico; Regazzoli, Damiano; Reimers, Bernhard; Muntané-Carol, Guillem; Estévez-Loureiro, Rodrigo; Espino, Antonio; Moscarelli, Marco; Armario, Xavier; Mylotte, Darren; Gorla, Riccardo; Bhadra, Oliver Daniel; Conradi, Lenard; Marroquin Donday, Luis Alfonso; Nombela-Franco, Luis; Barbanti, Marco; Reddavid, Claudia; Criscione, Enrico; Brugaletta, Salvatore; Regueiro, Ander; Pérez-Fuentes, Pedro; Nicolini, Elisa; Piva, Tommaso; Tzanis, Giorgos; Rodes-Cabau, Josep; Colombo, Antonio; Giannini, Francesco.

In: CIRC-CARDIOVASC INTE, Vol. 14, No. 9, e010641, 09.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gallo, F, Gallone, G, Kim, W-K, Reifart, J, Veulemans, V, Zeus, T, Toggweiler, S, De Backer, O, Søndergaard, L, Mangieri, A, Khokhar, A, De Marco, F, Regazzoli, D, Reimers, B, Muntané-Carol, G, Estévez-Loureiro, R, Espino, A, Moscarelli, M, Armario, X, Mylotte, D, Gorla, R, Bhadra, OD, Conradi, L, Marroquin Donday, LA, Nombela-Franco, L, Barbanti, M, Reddavid, C, Criscione, E, Brugaletta, S, Regueiro, A, Pérez-Fuentes, P, Nicolini, E, Piva, T, Tzanis, G, Rodes-Cabau, J, Colombo, A & Giannini, F 2021, 'Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry', CIRC-CARDIOVASC INTE, vol. 14, no. 9, e010641. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010641

APA

Gallo, F., Gallone, G., Kim, W-K., Reifart, J., Veulemans, V., Zeus, T., Toggweiler, S., De Backer, O., Søndergaard, L., Mangieri, A., Khokhar, A., De Marco, F., Regazzoli, D., Reimers, B., Muntané-Carol, G., Estévez-Loureiro, R., Espino, A., Moscarelli, M., Armario, X., ... Giannini, F. (2021). Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry. CIRC-CARDIOVASC INTE, 14(9), [e010641]. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010641

Vancouver

Gallo F, Gallone G, Kim W-K, Reifart J, Veulemans V, Zeus T et al. Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry. CIRC-CARDIOVASC INTE. 2021 Sep;14(9). e010641. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010641

Bibtex

@article{80de45f41d5e481bb0d7ccf156ed337e,
title = "Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry",
abstract = "Background:An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves.Methods:The HORSE (Horizontal Aorta in Transcatheter Self-Expanding Valves) is an international, retrospective registry including 3862 consecutive patients undergoing transcatheter aortic valve replacement with either Evolut R/PRO (n=1959) or ACURATE neo (n=1903) devices. Patients undergoing Evolut R 34 mm implantation were excluded as no comparable prosthesis size for ACURATE neo is available. AA was evaluated with preprocedural computed tomography, and its impact on device success was evaluated.Results:In the overall population, AA did not have any impact upon device success, also when adjusting for in-study outcome predictors (odds ratio for 1° increment, 0.99 [95% CI, 0.98–1.01], P=0.306). However, increased AA was associated with lower device success with use of the Evolut R/PRO valves (odds ratio, 0.97 [95% CI, 0.95–0.99]; P=0.004), but not the ACURATE neo valves (odds ratio, 1.00 [95% CI, 0.98–1.03], P=0.304). The best AA cutoff value predicting device success was 49° (47% of the study cohort). Among patients with AA≥49°, Evolut R/PRO valves were associated with lower device success as compared to the ACURATE neo valve (inverse probability weighting odds ratio, 0.62 [95% CI, 0.46–0.83]; P=0.002).Conclusions:Horizontal aorta, as defined by an AA ≥49°, is a common feature among transcatheter aortic valve replacement candidates and predicts device failure of the Evolut R/PRO valves, but not of the ACURATE neo valve. AA may be an effect modifier of the association between self-expanding valve type and device success.",
keywords = "Aorta, Aortic Valve/diagnostic imaging, Aortic Valve Stenosis/diagnostic imaging, Bioprosthesis, Heart Valve Prosthesis, Humans, Prosthesis Design, Registries, Transcatheter Aortic Valve Replacement/adverse effects, Treatment Outcome",
author = "Francesco Gallo and Guglielmo Gallone and Won-Keun Kim and J{\"o}rg Reifart and Verena Veulemans and Tobias Zeus and Stefan Toggweiler and {De Backer}, Ole and Lars S{\o}ndergaard and Antonio Mangieri and Arif Khokhar and {De Marco}, Federico and Damiano Regazzoli and Bernhard Reimers and Guillem Muntan{\'e}-Carol and Rodrigo Est{\'e}vez-Loureiro and Antonio Espino and Marco Moscarelli and Xavier Armario and Darren Mylotte and Riccardo Gorla and Bhadra, {Oliver Daniel} and Lenard Conradi and {Marroquin Donday}, {Luis Alfonso} and Luis Nombela-Franco and Marco Barbanti and Claudia Reddavid and Enrico Criscione and Salvatore Brugaletta and Ander Regueiro and Pedro P{\'e}rez-Fuentes and Elisa Nicolini and Tommaso Piva and Giorgos Tzanis and Josep Rodes-Cabau and Antonio Colombo and Francesco Giannini",
year = "2021",
month = sep,
doi = "10.1161/CIRCINTERVENTIONS.121.010641",
language = "English",
volume = "14",
journal = "CIRC-CARDIOVASC INTE",
issn = "1941-7640",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry

AU - Gallo, Francesco

AU - Gallone, Guglielmo

AU - Kim, Won-Keun

AU - Reifart, Jörg

AU - Veulemans, Verena

AU - Zeus, Tobias

AU - Toggweiler, Stefan

AU - De Backer, Ole

AU - Søndergaard, Lars

AU - Mangieri, Antonio

AU - Khokhar, Arif

AU - De Marco, Federico

AU - Regazzoli, Damiano

AU - Reimers, Bernhard

AU - Muntané-Carol, Guillem

AU - Estévez-Loureiro, Rodrigo

AU - Espino, Antonio

AU - Moscarelli, Marco

AU - Armario, Xavier

AU - Mylotte, Darren

AU - Gorla, Riccardo

AU - Bhadra, Oliver Daniel

AU - Conradi, Lenard

AU - Marroquin Donday, Luis Alfonso

AU - Nombela-Franco, Luis

AU - Barbanti, Marco

AU - Reddavid, Claudia

AU - Criscione, Enrico

AU - Brugaletta, Salvatore

AU - Regueiro, Ander

AU - Pérez-Fuentes, Pedro

AU - Nicolini, Elisa

AU - Piva, Tommaso

AU - Tzanis, Giorgos

AU - Rodes-Cabau, Josep

AU - Colombo, Antonio

AU - Giannini, Francesco

PY - 2021/9

Y1 - 2021/9

N2 - Background:An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves.Methods:The HORSE (Horizontal Aorta in Transcatheter Self-Expanding Valves) is an international, retrospective registry including 3862 consecutive patients undergoing transcatheter aortic valve replacement with either Evolut R/PRO (n=1959) or ACURATE neo (n=1903) devices. Patients undergoing Evolut R 34 mm implantation were excluded as no comparable prosthesis size for ACURATE neo is available. AA was evaluated with preprocedural computed tomography, and its impact on device success was evaluated.Results:In the overall population, AA did not have any impact upon device success, also when adjusting for in-study outcome predictors (odds ratio for 1° increment, 0.99 [95% CI, 0.98–1.01], P=0.306). However, increased AA was associated with lower device success with use of the Evolut R/PRO valves (odds ratio, 0.97 [95% CI, 0.95–0.99]; P=0.004), but not the ACURATE neo valves (odds ratio, 1.00 [95% CI, 0.98–1.03], P=0.304). The best AA cutoff value predicting device success was 49° (47% of the study cohort). Among patients with AA≥49°, Evolut R/PRO valves were associated with lower device success as compared to the ACURATE neo valve (inverse probability weighting odds ratio, 0.62 [95% CI, 0.46–0.83]; P=0.002).Conclusions:Horizontal aorta, as defined by an AA ≥49°, is a common feature among transcatheter aortic valve replacement candidates and predicts device failure of the Evolut R/PRO valves, but not of the ACURATE neo valve. AA may be an effect modifier of the association between self-expanding valve type and device success.

AB - Background:An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves.Methods:The HORSE (Horizontal Aorta in Transcatheter Self-Expanding Valves) is an international, retrospective registry including 3862 consecutive patients undergoing transcatheter aortic valve replacement with either Evolut R/PRO (n=1959) or ACURATE neo (n=1903) devices. Patients undergoing Evolut R 34 mm implantation were excluded as no comparable prosthesis size for ACURATE neo is available. AA was evaluated with preprocedural computed tomography, and its impact on device success was evaluated.Results:In the overall population, AA did not have any impact upon device success, also when adjusting for in-study outcome predictors (odds ratio for 1° increment, 0.99 [95% CI, 0.98–1.01], P=0.306). However, increased AA was associated with lower device success with use of the Evolut R/PRO valves (odds ratio, 0.97 [95% CI, 0.95–0.99]; P=0.004), but not the ACURATE neo valves (odds ratio, 1.00 [95% CI, 0.98–1.03], P=0.304). The best AA cutoff value predicting device success was 49° (47% of the study cohort). Among patients with AA≥49°, Evolut R/PRO valves were associated with lower device success as compared to the ACURATE neo valve (inverse probability weighting odds ratio, 0.62 [95% CI, 0.46–0.83]; P=0.002).Conclusions:Horizontal aorta, as defined by an AA ≥49°, is a common feature among transcatheter aortic valve replacement candidates and predicts device failure of the Evolut R/PRO valves, but not of the ACURATE neo valve. AA may be an effect modifier of the association between self-expanding valve type and device success.

KW - Aorta

KW - Aortic Valve/diagnostic imaging

KW - Aortic Valve Stenosis/diagnostic imaging

KW - Bioprosthesis

KW - Heart Valve Prosthesis

KW - Humans

KW - Prosthesis Design

KW - Registries

KW - Transcatheter Aortic Valve Replacement/adverse effects

KW - Treatment Outcome

U2 - 10.1161/CIRCINTERVENTIONS.121.010641

DO - 10.1161/CIRCINTERVENTIONS.121.010641

M3 - SCORING: Journal article

C2 - 34455799

VL - 14

JO - CIRC-CARDIOVASC INTE

JF - CIRC-CARDIOVASC INTE

SN - 1941-7640

IS - 9

M1 - e010641

ER -