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Homoarginine supplementation improves blood glucose in diet-induced obese mice

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Homoarginine supplementation improves blood glucose in diet-induced obese mice. / Stockebrand, Malte; Hornig, Sönke; Neu, Axel; Atzler, Dorothee; Cordts, Kathrin; Böger, Rainer H; Isbrandt, Dirk; Schwedhelm, Edzard; Choe, Chi-Un.

In: AMINO ACIDS, Vol. 47, No. 9, 09.2015, p. 1921-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stockebrand, M, Hornig, S, Neu, A, Atzler, D, Cordts, K, Böger, RH, Isbrandt, D, Schwedhelm, E & Choe, C-U 2015, 'Homoarginine supplementation improves blood glucose in diet-induced obese mice', AMINO ACIDS, vol. 47, no. 9, pp. 1921-9. https://doi.org/10.1007/s00726-015-2022-1

APA

Stockebrand, M., Hornig, S., Neu, A., Atzler, D., Cordts, K., Böger, R. H., Isbrandt, D., Schwedhelm, E., & Choe, C-U. (2015). Homoarginine supplementation improves blood glucose in diet-induced obese mice. AMINO ACIDS, 47(9), 1921-9. https://doi.org/10.1007/s00726-015-2022-1

Vancouver

Stockebrand M, Hornig S, Neu A, Atzler D, Cordts K, Böger RH et al. Homoarginine supplementation improves blood glucose in diet-induced obese mice. AMINO ACIDS. 2015 Sep;47(9):1921-9. https://doi.org/10.1007/s00726-015-2022-1

Bibtex

@article{8c3dfa3dff0c4ab79e56ece019c8d6ca,
title = "Homoarginine supplementation improves blood glucose in diet-induced obese mice",
abstract = "L-Homoarginine (hArg) is an endogenous amino acid which has emerged as a novel biomarker for stroke and cardiovascular disease. Low circulating hArg levels are associated with increased mortality and vascular events, whereas recent data have revealed positive correlations between circulating hArg and metabolic vascular risk factors like obesity or blood glucose levels. However, it is unclear whether hArg levels are causally linked to metabolic parameters. Therefore, the aim of our study was to investigate whether hArg directly influences body weight, blood glucose, glucose tolerance or insulin sensitivity. Here, we show that hArg supplementation (14 and 28 mg/mL orally per drinking water) ameliorates blood glucose levels in mice on high-fat diet (HFD) by a reduction of 7.3 ± 3.7 or 13.4 ± 3.8 %, respectively. Fasting insulin concentrations were slightly, yet significantly affected (63.8 ± 11.3 or 162.1 ± 39.5 % of control animals, respectively), whereas body weight and glucose tolerance were unaltered. The substantial augmentation of hArg plasma concentrations in supplemented animals (327.5 ± 40.4 or 627.5 ± 60.3 % of control animals, respectively) diminished profoundly after the animals became obese (129.9 ± 16.6 % in control animals after HFD vs. 140.1 ± 8.5 or 206.3 ± 13.6 %, respectively). This hArg-lowering effect may contribute to the discrepancy between the inverse correlation of plasma hArg levels with stroke and cardiovascular outcome, on the one hand, and the direct correlation with cardiovascular risk factors like obesity and blood glucose, on the other hand, that has been observed in human studies. Our results suggest that the glucose-lowering effects of hArg may reflect a compensatory mechanism of blood glucose reduction by hArg upregulation in obese individuals, without directly influencing body weight or glucose tolerance.",
author = "Malte Stockebrand and S{\"o}nke Hornig and Axel Neu and Dorothee Atzler and Kathrin Cordts and B{\"o}ger, {Rainer H} and Dirk Isbrandt and Edzard Schwedhelm and Chi-Un Choe",
year = "2015",
month = sep,
doi = "10.1007/s00726-015-2022-1",
language = "English",
volume = "47",
pages = "1921--9",
journal = "AMINO ACIDS",
issn = "0939-4451",
publisher = "Springer Wien",
number = "9",

}

RIS

TY - JOUR

T1 - Homoarginine supplementation improves blood glucose in diet-induced obese mice

AU - Stockebrand, Malte

AU - Hornig, Sönke

AU - Neu, Axel

AU - Atzler, Dorothee

AU - Cordts, Kathrin

AU - Böger, Rainer H

AU - Isbrandt, Dirk

AU - Schwedhelm, Edzard

AU - Choe, Chi-Un

PY - 2015/9

Y1 - 2015/9

N2 - L-Homoarginine (hArg) is an endogenous amino acid which has emerged as a novel biomarker for stroke and cardiovascular disease. Low circulating hArg levels are associated with increased mortality and vascular events, whereas recent data have revealed positive correlations between circulating hArg and metabolic vascular risk factors like obesity or blood glucose levels. However, it is unclear whether hArg levels are causally linked to metabolic parameters. Therefore, the aim of our study was to investigate whether hArg directly influences body weight, blood glucose, glucose tolerance or insulin sensitivity. Here, we show that hArg supplementation (14 and 28 mg/mL orally per drinking water) ameliorates blood glucose levels in mice on high-fat diet (HFD) by a reduction of 7.3 ± 3.7 or 13.4 ± 3.8 %, respectively. Fasting insulin concentrations were slightly, yet significantly affected (63.8 ± 11.3 or 162.1 ± 39.5 % of control animals, respectively), whereas body weight and glucose tolerance were unaltered. The substantial augmentation of hArg plasma concentrations in supplemented animals (327.5 ± 40.4 or 627.5 ± 60.3 % of control animals, respectively) diminished profoundly after the animals became obese (129.9 ± 16.6 % in control animals after HFD vs. 140.1 ± 8.5 or 206.3 ± 13.6 %, respectively). This hArg-lowering effect may contribute to the discrepancy between the inverse correlation of plasma hArg levels with stroke and cardiovascular outcome, on the one hand, and the direct correlation with cardiovascular risk factors like obesity and blood glucose, on the other hand, that has been observed in human studies. Our results suggest that the glucose-lowering effects of hArg may reflect a compensatory mechanism of blood glucose reduction by hArg upregulation in obese individuals, without directly influencing body weight or glucose tolerance.

AB - L-Homoarginine (hArg) is an endogenous amino acid which has emerged as a novel biomarker for stroke and cardiovascular disease. Low circulating hArg levels are associated with increased mortality and vascular events, whereas recent data have revealed positive correlations between circulating hArg and metabolic vascular risk factors like obesity or blood glucose levels. However, it is unclear whether hArg levels are causally linked to metabolic parameters. Therefore, the aim of our study was to investigate whether hArg directly influences body weight, blood glucose, glucose tolerance or insulin sensitivity. Here, we show that hArg supplementation (14 and 28 mg/mL orally per drinking water) ameliorates blood glucose levels in mice on high-fat diet (HFD) by a reduction of 7.3 ± 3.7 or 13.4 ± 3.8 %, respectively. Fasting insulin concentrations were slightly, yet significantly affected (63.8 ± 11.3 or 162.1 ± 39.5 % of control animals, respectively), whereas body weight and glucose tolerance were unaltered. The substantial augmentation of hArg plasma concentrations in supplemented animals (327.5 ± 40.4 or 627.5 ± 60.3 % of control animals, respectively) diminished profoundly after the animals became obese (129.9 ± 16.6 % in control animals after HFD vs. 140.1 ± 8.5 or 206.3 ± 13.6 %, respectively). This hArg-lowering effect may contribute to the discrepancy between the inverse correlation of plasma hArg levels with stroke and cardiovascular outcome, on the one hand, and the direct correlation with cardiovascular risk factors like obesity and blood glucose, on the other hand, that has been observed in human studies. Our results suggest that the glucose-lowering effects of hArg may reflect a compensatory mechanism of blood glucose reduction by hArg upregulation in obese individuals, without directly influencing body weight or glucose tolerance.

U2 - 10.1007/s00726-015-2022-1

DO - 10.1007/s00726-015-2022-1

M3 - SCORING: Journal article

C2 - 26077714

VL - 47

SP - 1921

EP - 1929

JO - AMINO ACIDS

JF - AMINO ACIDS

SN - 0939-4451

IS - 9

ER -