Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
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Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells. / Lunemann, Sebastian; Martrus, Gloria; Goebels, Hanna; Kautz, Tobias; Langeneckert, Annika; Salzberger, Wilhelm; Koch, Martina; J Bunders, Madeleine; Nashan, Björn; van Gisbergen, Klaas P J M; Altfeld, Marcus.
In: SCI REP-UK, Vol. 7, No. 1, 27.07.2017, p. 6676.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
AU - Lunemann, Sebastian
AU - Martrus, Gloria
AU - Goebels, Hanna
AU - Kautz, Tobias
AU - Langeneckert, Annika
AU - Salzberger, Wilhelm
AU - Koch, Martina
AU - J Bunders, Madeleine
AU - Nashan, Björn
AU - van Gisbergen, Klaas P J M
AU - Altfeld, Marcus
PY - 2017/7/27
Y1 - 2017/7/27
N2 - Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown. Our aim was to assess the expression and contribution of Hobit to tissue-residency of Natural Killer (NK) cells in the human liver. The human liver was enriched for CD56bright NK cells showing increased expression levels of the transcription factor Hobit. Hobitpos CD56bright NK cells in the liver exhibited high levels of CD49a, CXCR6 and CD69. Hobitpos CD56bright NK cells in the liver furthermore expressed a unique set of transcription factors with higher frequencies and levels of T-bet and Blimp-1 when compared to Hobitneg CD56bright NK cells. Taken together, we show that the transcription factor Hobit identifies a subset of NK cells in human livers that express a distinct set of adhesion molecules and chemokine receptors consistent with tissue residency. These data suggest that Hobit is involved in regulating tissue-residency of human intrahepatic CD56bright NK cells in a subset of NK cells in inflamed livers.
AB - Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown. Our aim was to assess the expression and contribution of Hobit to tissue-residency of Natural Killer (NK) cells in the human liver. The human liver was enriched for CD56bright NK cells showing increased expression levels of the transcription factor Hobit. Hobitpos CD56bright NK cells in the liver exhibited high levels of CD49a, CXCR6 and CD69. Hobitpos CD56bright NK cells in the liver furthermore expressed a unique set of transcription factors with higher frequencies and levels of T-bet and Blimp-1 when compared to Hobitneg CD56bright NK cells. Taken together, we show that the transcription factor Hobit identifies a subset of NK cells in human livers that express a distinct set of adhesion molecules and chemokine receptors consistent with tissue residency. These data suggest that Hobit is involved in regulating tissue-residency of human intrahepatic CD56bright NK cells in a subset of NK cells in inflamed livers.
KW - Journal Article
U2 - 10.1038/s41598-017-06011-7
DO - 10.1038/s41598-017-06011-7
M3 - SCORING: Journal article
C2 - 28751776
VL - 7
SP - 6676
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -