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HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

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HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. / Feger, Ute; Tolosa, Eva; Huang, Yu-Hwa; Waschbisch, Anne; Biedermann, Tilo; Melms, Arthur; Wiendl, Heinz.

In: BLOOD, Vol. 110, No. 2, 2, 2007, p. 568-577.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Feger, U, Tolosa, E, Huang, Y-H, Waschbisch, A, Biedermann, T, Melms, A & Wiendl, H 2007, 'HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.', BLOOD, vol. 110, no. 2, 2, pp. 568-577. <http://www.ncbi.nlm.nih.gov/pubmed/17371944?dopt=Citation>

APA

Feger, U., Tolosa, E., Huang, Y-H., Waschbisch, A., Biedermann, T., Melms, A., & Wiendl, H. (2007). HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. BLOOD, 110(2), 568-577. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17371944?dopt=Citation

Vancouver

Feger U, Tolosa E, Huang Y-H, Waschbisch A, Biedermann T, Melms A et al. HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. BLOOD. 2007;110(2):568-577. 2.

Bibtex

@article{6b3f670783174f49a519a6bf7a5e3f69,
title = "HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.",
abstract = "Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G-expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G-positive (HLA-G(pos)) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-G(pos) T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.",
keywords = "Humans, Phenotype, Lymphocyte Activation, Polymerase Chain Reaction, DNA Primers, HLA Antigens/*genetics, Immunosuppression, T-Lymphocytes/immunology, T-Lymphocytes, Regulatory/*immunology, RNA/genetics/isolation & purification, CD8-Positive T-Lymphocytes/immunology, T-Lymphocyte Subsets/immunology, Dendritic Cells/immunology, CD4-Positive T-Lymphocytes/immunology, HLA-G Antigens, Histocompatibility Antigens Class I/*genetics, Inflammation/*immunology, Muscle, Skeletal/immunology/physiopathology, Humans, Phenotype, Lymphocyte Activation, Polymerase Chain Reaction, DNA Primers, HLA Antigens/*genetics, Immunosuppression, T-Lymphocytes/immunology, T-Lymphocytes, Regulatory/*immunology, RNA/genetics/isolation & purification, CD8-Positive T-Lymphocytes/immunology, T-Lymphocyte Subsets/immunology, Dendritic Cells/immunology, CD4-Positive T-Lymphocytes/immunology, HLA-G Antigens, Histocompatibility Antigens Class I/*genetics, Inflammation/*immunology, Muscle, Skeletal/immunology/physiopathology",
author = "Ute Feger and Eva Tolosa and Yu-Hwa Huang and Anne Waschbisch and Tilo Biedermann and Arthur Melms and Heinz Wiendl",
year = "2007",
language = "English",
volume = "110",
pages = "568--577",
journal = "BLOOD",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "2",

}

RIS

TY - JOUR

T1 - HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

AU - Feger, Ute

AU - Tolosa, Eva

AU - Huang, Yu-Hwa

AU - Waschbisch, Anne

AU - Biedermann, Tilo

AU - Melms, Arthur

AU - Wiendl, Heinz

PY - 2007

Y1 - 2007

N2 - Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G-expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G-positive (HLA-G(pos)) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-G(pos) T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.

AB - Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G-expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G-positive (HLA-G(pos)) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-G(pos) T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.

KW - Humans

KW - Phenotype

KW - Lymphocyte Activation

KW - Polymerase Chain Reaction

KW - DNA Primers

KW - HLA Antigens/genetics

KW - Immunosuppression

KW - T-Lymphocytes/immunology

KW - T-Lymphocytes, Regulatory/immunology

KW - RNA/genetics/isolation & purification

KW - CD8-Positive T-Lymphocytes/immunology

KW - T-Lymphocyte Subsets/immunology

KW - Dendritic Cells/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - HLA-G Antigens

KW - Histocompatibility Antigens Class I/genetics

KW - Inflammation/immunology

KW - Muscle, Skeletal/immunology/physiopathology

KW - Humans

KW - Phenotype

KW - Lymphocyte Activation

KW - Polymerase Chain Reaction

KW - DNA Primers

KW - HLA Antigens/genetics

KW - Immunosuppression

KW - T-Lymphocytes/immunology

KW - T-Lymphocytes, Regulatory/immunology

KW - RNA/genetics/isolation & purification

KW - CD8-Positive T-Lymphocytes/immunology

KW - T-Lymphocyte Subsets/immunology

KW - Dendritic Cells/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - HLA-G Antigens

KW - Histocompatibility Antigens Class I/genetics

KW - Inflammation/immunology

KW - Muscle, Skeletal/immunology/physiopathology

M3 - SCORING: Journal article

VL - 110

SP - 568

EP - 577

JO - BLOOD

JF - BLOOD

SN - 0006-4971

IS - 2

M1 - 2

ER -