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HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells

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HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. / Körner, Christian; Simoneau, Camille R; Schommers, Philipp; Granoff, Mitchell; Ziegler, Maja; Hölzemer, Angelique; Lunemann, Sebastian; Chukwukelu, Janet; Corleis, Björn; Naranbhai, Vivek; Kwon, Douglas S; Scully, Eileen P; Jost, Stephanie; Kirchhoff, Frank; Carrington, Mary; Altfeld, Marcus.

In: CELL HOST MICROBE, Vol. 22, No. 1, 12.07.2017, p. 111-119.e4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Körner, C, Simoneau, CR, Schommers, P, Granoff, M, Ziegler, M, Hölzemer, A, Lunemann, S, Chukwukelu, J, Corleis, B, Naranbhai, V, Kwon, DS, Scully, EP, Jost, S, Kirchhoff, F, Carrington, M & Altfeld, M 2017, 'HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells', CELL HOST MICROBE, vol. 22, no. 1, pp. 111-119.e4. https://doi.org/10.1016/j.chom.2017.06.008

APA

Körner, C., Simoneau, C. R., Schommers, P., Granoff, M., Ziegler, M., Hölzemer, A., Lunemann, S., Chukwukelu, J., Corleis, B., Naranbhai, V., Kwon, D. S., Scully, E. P., Jost, S., Kirchhoff, F., Carrington, M., & Altfeld, M. (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. CELL HOST MICROBE, 22(1), 111-119.e4. https://doi.org/10.1016/j.chom.2017.06.008

Vancouver

Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A et al. HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. CELL HOST MICROBE. 2017 Jul 12;22(1):111-119.e4. https://doi.org/10.1016/j.chom.2017.06.008

Bibtex

@article{1b88b0cc921a4a56b216aab74703fe23,
title = "HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells",
abstract = "It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity compared to their unlicensed counterparts, potentially due to residual binding to the respective inhibitory receptors. Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increased antiviral activity when exposed to viral strains with differential abilities to downmodulate HLA-C. These results suggest that the capability of HLA-C-licensed NK cells to control HIV-1 replication is determined by the strength of KIR/HLA-C interactions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregulation.",
keywords = "Journal Article",
author = "Christian K{\"o}rner and Simoneau, {Camille R} and Philipp Schommers and Mitchell Granoff and Maja Ziegler and Angelique H{\"o}lzemer and Sebastian Lunemann and Janet Chukwukelu and Bj{\"o}rn Corleis and Vivek Naranbhai and Kwon, {Douglas S} and Scully, {Eileen P} and Stephanie Jost and Frank Kirchhoff and Mary Carrington and Marcus Altfeld",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = jul,
day = "12",
doi = "10.1016/j.chom.2017.06.008",
language = "English",
volume = "22",
pages = "111--119.e4",
journal = "CELL HOST MICROBE",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells

AU - Körner, Christian

AU - Simoneau, Camille R

AU - Schommers, Philipp

AU - Granoff, Mitchell

AU - Ziegler, Maja

AU - Hölzemer, Angelique

AU - Lunemann, Sebastian

AU - Chukwukelu, Janet

AU - Corleis, Björn

AU - Naranbhai, Vivek

AU - Kwon, Douglas S

AU - Scully, Eileen P

AU - Jost, Stephanie

AU - Kirchhoff, Frank

AU - Carrington, Mary

AU - Altfeld, Marcus

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/7/12

Y1 - 2017/7/12

N2 - It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity compared to their unlicensed counterparts, potentially due to residual binding to the respective inhibitory receptors. Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increased antiviral activity when exposed to viral strains with differential abilities to downmodulate HLA-C. These results suggest that the capability of HLA-C-licensed NK cells to control HIV-1 replication is determined by the strength of KIR/HLA-C interactions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregulation.

AB - It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity compared to their unlicensed counterparts, potentially due to residual binding to the respective inhibitory receptors. Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increased antiviral activity when exposed to viral strains with differential abilities to downmodulate HLA-C. These results suggest that the capability of HLA-C-licensed NK cells to control HIV-1 replication is determined by the strength of KIR/HLA-C interactions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregulation.

KW - Journal Article

U2 - 10.1016/j.chom.2017.06.008

DO - 10.1016/j.chom.2017.06.008

M3 - SCORING: Journal article

C2 - 28704647

VL - 22

SP - 111-119.e4

JO - CELL HOST MICROBE

JF - CELL HOST MICROBE

SN - 1931-3128

IS - 1

ER -