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Histopathological patterns of nephrocalcinosis

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Histopathological patterns of nephrocalcinosis : a phosphate type can be distinguished from a calcium type. / Wiech, Thorsten; Hopfer, Helmut; Gaspert, Ariana; Banyai-Falger, Susanne; Hausberg, Martin; Schröder, Josef; Werner, Martin; Mihatsch, Michael J.

In: NEPHROL DIAL TRANSPL, Vol. 27, No. 3, 01.03.2012, p. 1122-31.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiech, T, Hopfer, H, Gaspert, A, Banyai-Falger, S, Hausberg, M, Schröder, J, Werner, M & Mihatsch, MJ 2012, 'Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type', NEPHROL DIAL TRANSPL, vol. 27, no. 3, pp. 1122-31. https://doi.org/10.1093/ndt/gfr414

APA

Wiech, T., Hopfer, H., Gaspert, A., Banyai-Falger, S., Hausberg, M., Schröder, J., Werner, M., & Mihatsch, M. J. (2012). Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type. NEPHROL DIAL TRANSPL, 27(3), 1122-31. https://doi.org/10.1093/ndt/gfr414

Vancouver

Wiech T, Hopfer H, Gaspert A, Banyai-Falger S, Hausberg M, Schröder J et al. Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type. NEPHROL DIAL TRANSPL. 2012 Mar 1;27(3):1122-31. https://doi.org/10.1093/ndt/gfr414

Bibtex

@article{6db2fc9731f54e3daf3351df79e3e3c7,
title = "Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type",
abstract = "BACKGROUND: The etiology of nephrocalcinosis is variable. In this study, we wanted to elucidate whether the histopathological appearance of calcium phosphate deposits provides information about possible etiology.METHODS: Autopsy cases from the years 1988 to 2007 and native kidney biopsies from a 50-year period (1959-2008) with nephrocalcinosis were identified. The biopsy cases were re-evaluated by light microscopy. The autopsy cases were analysed according to the underlying disease. The biopsy cases were grouped with respect to the likely etiology of nephrocalcinosis. Total number, density, localization, size and pattern of all calcification foci were documented and correlated with clinical and laboratory data.RESULTS: About 223 of 12,960 autopsy cases (1.7%) had nephrocalcinosis, 111 of which (49.8%) suffered from advanced malignant tumours. Nephrocalcinosis was the main diagnosis in 48 of 12,480 native kidney biopsies (0.4%). Clinicopathological correlation revealed a specific pattern of calcification associated with hyperphosphataemia and/or hyperphosphaturia: these cases showed predominant globular or shell-like calcifications (phosphate type). In contrast, the biopsies of the hypercalcaemic/hypercalciuric group had a different predominant pattern with clumpy or finely granular calcifications (calcium type).CONCLUSIONS: Our results indicate that hyperphosphaturia-associated cases of nephrocalcinosis can be distinguished from hypercalciuria-associated cases histopathologically.",
keywords = "Adolescent, Adult, Aged, Autopsy, Calcium, Child, Child, Preschool, Female, Humans, Hypophosphatemia, Familial, Infant, Male, Middle Aged, Neoplasms, Nephrocalcinosis, Phosphates, Prognosis, Young Adult",
author = "Thorsten Wiech and Helmut Hopfer and Ariana Gaspert and Susanne Banyai-Falger and Martin Hausberg and Josef Schr{\"o}der and Martin Werner and Mihatsch, {Michael J}",
year = "2012",
month = mar,
day = "1",
doi = "10.1093/ndt/gfr414",
language = "English",
volume = "27",
pages = "1122--31",
journal = "NEPHROL DIAL TRANSPL",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Histopathological patterns of nephrocalcinosis

T2 - a phosphate type can be distinguished from a calcium type

AU - Wiech, Thorsten

AU - Hopfer, Helmut

AU - Gaspert, Ariana

AU - Banyai-Falger, Susanne

AU - Hausberg, Martin

AU - Schröder, Josef

AU - Werner, Martin

AU - Mihatsch, Michael J

PY - 2012/3/1

Y1 - 2012/3/1

N2 - BACKGROUND: The etiology of nephrocalcinosis is variable. In this study, we wanted to elucidate whether the histopathological appearance of calcium phosphate deposits provides information about possible etiology.METHODS: Autopsy cases from the years 1988 to 2007 and native kidney biopsies from a 50-year period (1959-2008) with nephrocalcinosis were identified. The biopsy cases were re-evaluated by light microscopy. The autopsy cases were analysed according to the underlying disease. The biopsy cases were grouped with respect to the likely etiology of nephrocalcinosis. Total number, density, localization, size and pattern of all calcification foci were documented and correlated with clinical and laboratory data.RESULTS: About 223 of 12,960 autopsy cases (1.7%) had nephrocalcinosis, 111 of which (49.8%) suffered from advanced malignant tumours. Nephrocalcinosis was the main diagnosis in 48 of 12,480 native kidney biopsies (0.4%). Clinicopathological correlation revealed a specific pattern of calcification associated with hyperphosphataemia and/or hyperphosphaturia: these cases showed predominant globular or shell-like calcifications (phosphate type). In contrast, the biopsies of the hypercalcaemic/hypercalciuric group had a different predominant pattern with clumpy or finely granular calcifications (calcium type).CONCLUSIONS: Our results indicate that hyperphosphaturia-associated cases of nephrocalcinosis can be distinguished from hypercalciuria-associated cases histopathologically.

AB - BACKGROUND: The etiology of nephrocalcinosis is variable. In this study, we wanted to elucidate whether the histopathological appearance of calcium phosphate deposits provides information about possible etiology.METHODS: Autopsy cases from the years 1988 to 2007 and native kidney biopsies from a 50-year period (1959-2008) with nephrocalcinosis were identified. The biopsy cases were re-evaluated by light microscopy. The autopsy cases were analysed according to the underlying disease. The biopsy cases were grouped with respect to the likely etiology of nephrocalcinosis. Total number, density, localization, size and pattern of all calcification foci were documented and correlated with clinical and laboratory data.RESULTS: About 223 of 12,960 autopsy cases (1.7%) had nephrocalcinosis, 111 of which (49.8%) suffered from advanced malignant tumours. Nephrocalcinosis was the main diagnosis in 48 of 12,480 native kidney biopsies (0.4%). Clinicopathological correlation revealed a specific pattern of calcification associated with hyperphosphataemia and/or hyperphosphaturia: these cases showed predominant globular or shell-like calcifications (phosphate type). In contrast, the biopsies of the hypercalcaemic/hypercalciuric group had a different predominant pattern with clumpy or finely granular calcifications (calcium type).CONCLUSIONS: Our results indicate that hyperphosphaturia-associated cases of nephrocalcinosis can be distinguished from hypercalciuria-associated cases histopathologically.

KW - Adolescent

KW - Adult

KW - Aged

KW - Autopsy

KW - Calcium

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Hypophosphatemia, Familial

KW - Infant

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Nephrocalcinosis

KW - Phosphates

KW - Prognosis

KW - Young Adult

U2 - 10.1093/ndt/gfr414

DO - 10.1093/ndt/gfr414

M3 - SCORING: Journal article

C2 - 21804087

VL - 27

SP - 1122

EP - 1131

JO - NEPHROL DIAL TRANSPL

JF - NEPHROL DIAL TRANSPL

SN - 0931-0509

IS - 3

ER -