Histomorphologische und sialoszintigraphische Befunde zur Radiosialadenitis unter fraktionierter Bestrahlung der Kopf-Hals-Region von Ratten. Ein Modell zur Evaluierung potenziell radioprotektiver Substanzen
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Histomorphologische und sialoszintigraphische Befunde zur Radiosialadenitis unter fraktionierter Bestrahlung der Kopf-Hals-Region von Ratten. Ein Modell zur Evaluierung potenziell radioprotektiver Substanzen. / Sagowski, C; Wenzel, S; Riehle, I; Tesche, S; Jenicke, L; Zywietz, F; Roeser, K; Metternich, F U.
In: HNO, Vol. 52, No. 1, 01.2004, p. 25-32.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Histomorphologische und sialoszintigraphische Befunde zur Radiosialadenitis unter fraktionierter Bestrahlung der Kopf-Hals-Region von Ratten. Ein Modell zur Evaluierung potenziell radioprotektiver Substanzen
AU - Sagowski, C
AU - Wenzel, S
AU - Riehle, I
AU - Tesche, S
AU - Jenicke, L
AU - Zywietz, F
AU - Roeser, K
AU - Metternich, F U
PY - 2004/1
Y1 - 2004/1
N2 - INTRODUCTION: The aim of this study was to correlate structural, histomorphological damage of the salivary gland with scintigraphic findings during fractioned radiotherapy.METHODS: The head and neck area of 27 WAG/RijH rats was irradiated with (60)Co-gamma-rays (60 Gy/30f/6 weeks). A port-system was implanted and (99m)Tc-pertechnetat applied at different stages of irradiation (0, 16, 30, 46, 60 Gy and 6 months post irradiation).RESULTS: After the application of 16 Gy an intra- and extra-cellular oedema developed in the salivary glands. The progressive vacuolisation (30 Gy) passed over into lipomatosis (46 Gy) and necrosis (60 Gy) in the parotid and mandibular glands. Six months after irradiation treatment, the chronic histomorphological damage corresponded to stage II according to Seifert. The corresponding loss in gland function was 13% (16 Gy); 26% (30 Gy); 57% (46 Gy); 75% (60 Gy) and 66.5% (6 months post irradiation).CONCLUSION: This animal model demonstrates the correlation between histomorphological and scintigraphic findings.
AB - INTRODUCTION: The aim of this study was to correlate structural, histomorphological damage of the salivary gland with scintigraphic findings during fractioned radiotherapy.METHODS: The head and neck area of 27 WAG/RijH rats was irradiated with (60)Co-gamma-rays (60 Gy/30f/6 weeks). A port-system was implanted and (99m)Tc-pertechnetat applied at different stages of irradiation (0, 16, 30, 46, 60 Gy and 6 months post irradiation).RESULTS: After the application of 16 Gy an intra- and extra-cellular oedema developed in the salivary glands. The progressive vacuolisation (30 Gy) passed over into lipomatosis (46 Gy) and necrosis (60 Gy) in the parotid and mandibular glands. Six months after irradiation treatment, the chronic histomorphological damage corresponded to stage II according to Seifert. The corresponding loss in gland function was 13% (16 Gy); 26% (30 Gy); 57% (46 Gy); 75% (60 Gy) and 66.5% (6 months post irradiation).CONCLUSION: This animal model demonstrates the correlation between histomorphological and scintigraphic findings.
KW - Animals
KW - Cobalt Radioisotopes
KW - Disease Models, Animal
KW - Dose Fractionation
KW - Dose-Response Relationship, Radiation
KW - Lipomatosis
KW - Male
KW - Parotid Gland
KW - Radiation Injuries, Experimental
KW - Radiation-Protective Agents
KW - Radioisotope Teletherapy
KW - Radionuclide Imaging
KW - Rats
KW - Rats, Inbred Strains
KW - Salivary Glands
KW - Sodium Pertechnetate Tc 99m
KW - Statistics as Topic
KW - Submandibular Gland
KW - Journal Article
U2 - 10.1007/s00106-003-0855-5
DO - 10.1007/s00106-003-0855-5
M3 - SCORING: Zeitschriftenaufsatz
C2 - 14740111
VL - 52
SP - 25
EP - 32
JO - HNO
JF - HNO
SN - 0017-6192
IS - 1
ER -
