Hirano bodies and chronic alcoholism

R Laas; C Hagel

Hirano bodies and chronic alcoholism

Standard

Hirano bodies and chronic alcoholism. / Laas, R; Hagel, C.

In: NEUROPATH APPL NEURO, Vol. 20, No. 1, 01.02.1994, p. 12-21.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Laas, R & Hagel, C 1994, 'Hirano bodies and chronic alcoholism', NEUROPATH APPL NEURO, vol. 20, no. 1, pp. 12-21.

APA

Laas, R., & Hagel, C. (1994). Hirano bodies and chronic alcoholism. NEUROPATH APPL NEURO, 20(1), 12-21.

Vancouver

Laas R, Hagel C. Hirano bodies and chronic alcoholism. NEUROPATH APPL NEURO. 1994 Feb 1;20(1):12-21.

Bibtex

@article{f4a3e80259474b638b53b04b35f057fb,

title = "Hirano bodies and chronic alcoholism",

abstract = "Experiments on rodents have shown convincingly that chronic ethanol ingestion may damage the hippocampal formation. Nevertheless this region has, hitherto, not been considered as a target for alcoholism-induced brain lesions in man. Guided by the observation of increased numbers of Hirano bodies (HB) in the hippocampus of chronic alcoholics, this study determines the maximum number of HB per high power field (HPF: 0.19 mm2) in the stratum pyramidale (HBpyr) and in the stratum lacunosum (HBlac) of Ammon's horn in 123 chronic alcoholics and in 197 controls. The average count of HBlac found in alcoholics was 14.4 (SD = 17.7) compared with 4.2 (SD = 7.4) in non-alcoholics (P < 0.001). Counts of more than 19 HBlac per HPF were revealed as highly indicative of chronic alcoholism being observed in 33 (27%) alcoholics and in six (3%) non-alcoholics (P < 0.001). An increased number of HBlac was the most frequent of the neuropathological findings in the alcoholics. Affirming observations of others, the count of HBlac peaked during middle age and declined thereafter. The maximum count of HBpyr, in contrast, increased with age and was independent of alcoholism. It is proposed that increased numbers of HBlac indicate alterations of the apical dendrites of the pyramidal neurons of the CA1 field of Ammon's horn which probably are due to direct neurotoxic effects of ethanol and which may be reversible in nature.",

keywords = "Adult, Aged, Aging, Alcoholism, Female, Hippocampus, Humans, Inclusion Bodies, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Sex Characteristics",

author = "R Laas and C Hagel",

year = "1994",

month = feb,

day = "1",

language = "English",

volume = "20",

pages = "12--21",

journal = "NEUROPATH APPL NEURO",

issn = "0305-1846",

publisher = "Wiley-Blackwell",

number = "1",

}

RIS

TY - JOUR

T1 - Hirano bodies and chronic alcoholism

AU - Laas, R

AU - Hagel, C

PY - 1994/2/1

Y1 - 1994/2/1

N2 - Experiments on rodents have shown convincingly that chronic ethanol ingestion may damage the hippocampal formation. Nevertheless this region has, hitherto, not been considered as a target for alcoholism-induced brain lesions in man. Guided by the observation of increased numbers of Hirano bodies (HB) in the hippocampus of chronic alcoholics, this study determines the maximum number of HB per high power field (HPF: 0.19 mm2) in the stratum pyramidale (HBpyr) and in the stratum lacunosum (HBlac) of Ammon's horn in 123 chronic alcoholics and in 197 controls. The average count of HBlac found in alcoholics was 14.4 (SD = 17.7) compared with 4.2 (SD = 7.4) in non-alcoholics (P < 0.001). Counts of more than 19 HBlac per HPF were revealed as highly indicative of chronic alcoholism being observed in 33 (27%) alcoholics and in six (3%) non-alcoholics (P < 0.001). An increased number of HBlac was the most frequent of the neuropathological findings in the alcoholics. Affirming observations of others, the count of HBlac peaked during middle age and declined thereafter. The maximum count of HBpyr, in contrast, increased with age and was independent of alcoholism. It is proposed that increased numbers of HBlac indicate alterations of the apical dendrites of the pyramidal neurons of the CA1 field of Ammon's horn which probably are due to direct neurotoxic effects of ethanol and which may be reversible in nature.

AB - Experiments on rodents have shown convincingly that chronic ethanol ingestion may damage the hippocampal formation. Nevertheless this region has, hitherto, not been considered as a target for alcoholism-induced brain lesions in man. Guided by the observation of increased numbers of Hirano bodies (HB) in the hippocampus of chronic alcoholics, this study determines the maximum number of HB per high power field (HPF: 0.19 mm2) in the stratum pyramidale (HBpyr) and in the stratum lacunosum (HBlac) of Ammon's horn in 123 chronic alcoholics and in 197 controls. The average count of HBlac found in alcoholics was 14.4 (SD = 17.7) compared with 4.2 (SD = 7.4) in non-alcoholics (P < 0.001). Counts of more than 19 HBlac per HPF were revealed as highly indicative of chronic alcoholism being observed in 33 (27%) alcoholics and in six (3%) non-alcoholics (P < 0.001). An increased number of HBlac was the most frequent of the neuropathological findings in the alcoholics. Affirming observations of others, the count of HBlac peaked during middle age and declined thereafter. The maximum count of HBpyr, in contrast, increased with age and was independent of alcoholism. It is proposed that increased numbers of HBlac indicate alterations of the apical dendrites of the pyramidal neurons of the CA1 field of Ammon's horn which probably are due to direct neurotoxic effects of ethanol and which may be reversible in nature.

KW - Adult

KW - Aged

KW - Aging

KW - Alcoholism

KW - Female

KW - Hippocampus

KW - Humans

KW - Inclusion Bodies

KW - Liver Cirrhosis, Alcoholic

KW - Male

KW - Middle Aged

KW - Sex Characteristics

M3 - SCORING: Journal article

C2 - 8208336

VL - 20

SP - 12

EP - 21

JO - NEUROPATH APPL NEURO

JF - NEUROPATH APPL NEURO

SN - 0305-1846

IS - 1

ER -