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Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation

Standard

Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation. / Kunz, Lukas; Wang, Liang; Lachner-Piza, Daniel; Zhang, Hui; Brandt, Armin; Dümpelmann, Matthias; Reinacher, Peter C; Coenen, Volker A; Chen, Dong; Wang, Wen-Xu; Zhou, Wenjing; Liang, Shuli; Grewe, Philip; Bien, Christian G; Bierbrauer, Anne; Navarro Schröder, Tobias; Schulze-Bonhage, Andreas; Axmacher, Nikolai.

In: SCI ADV, Vol. 5, No. 7, 07.2019, p. eaav8192.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kunz, L, Wang, L, Lachner-Piza, D, Zhang, H, Brandt, A, Dümpelmann, M, Reinacher, PC, Coenen, VA, Chen, D, Wang, W-X, Zhou, W, Liang, S, Grewe, P, Bien, CG, Bierbrauer, A, Navarro Schröder, T, Schulze-Bonhage, A & Axmacher, N 2019, 'Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation', SCI ADV, vol. 5, no. 7, pp. eaav8192. https://doi.org/10.1126/sciadv.aav8192

APA

Kunz, L., Wang, L., Lachner-Piza, D., Zhang, H., Brandt, A., Dümpelmann, M., Reinacher, P. C., Coenen, V. A., Chen, D., Wang, W-X., Zhou, W., Liang, S., Grewe, P., Bien, C. G., Bierbrauer, A., Navarro Schröder, T., Schulze-Bonhage, A., & Axmacher, N. (2019). Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation. SCI ADV, 5(7), eaav8192. https://doi.org/10.1126/sciadv.aav8192

Vancouver

Kunz L, Wang L, Lachner-Piza D, Zhang H, Brandt A, Dümpelmann M et al. Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation. SCI ADV. 2019 Jul;5(7):eaav8192. https://doi.org/10.1126/sciadv.aav8192

Bibtex

@article{76067fbe35d6404cbdc18913c662a025,
title = "Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation",
abstract = "Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.",
keywords = "Adult, Epilepsy/physiopathology, Female, Goals, Hippocampus/diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Mental Navigation Tests, Signal Processing, Computer-Assisted, Spatial Navigation, Theta Rhythm/physiology",
author = "Lukas Kunz and Liang Wang and Daniel Lachner-Piza and Hui Zhang and Armin Brandt and Matthias D{\"u}mpelmann and Reinacher, {Peter C} and Coenen, {Volker A} and Dong Chen and Wen-Xu Wang and Wenjing Zhou and Shuli Liang and Philip Grewe and Bien, {Christian G} and Anne Bierbrauer and {Navarro Schr{\"o}der}, Tobias and Andreas Schulze-Bonhage and Nikolai Axmacher",
year = "2019",
month = jul,
doi = "10.1126/sciadv.aav8192",
language = "English",
volume = "5",
pages = "eaav8192",
journal = "SCI ADV",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation

AU - Kunz, Lukas

AU - Wang, Liang

AU - Lachner-Piza, Daniel

AU - Zhang, Hui

AU - Brandt, Armin

AU - Dümpelmann, Matthias

AU - Reinacher, Peter C

AU - Coenen, Volker A

AU - Chen, Dong

AU - Wang, Wen-Xu

AU - Zhou, Wenjing

AU - Liang, Shuli

AU - Grewe, Philip

AU - Bien, Christian G

AU - Bierbrauer, Anne

AU - Navarro Schröder, Tobias

AU - Schulze-Bonhage, Andreas

AU - Axmacher, Nikolai

PY - 2019/7

Y1 - 2019/7

N2 - Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.

AB - Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.

KW - Adult

KW - Epilepsy/physiopathology

KW - Female

KW - Goals

KW - Hippocampus/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Mental Navigation Tests

KW - Signal Processing, Computer-Assisted

KW - Spatial Navigation

KW - Theta Rhythm/physiology

U2 - 10.1126/sciadv.aav8192

DO - 10.1126/sciadv.aav8192

M3 - SCORING: Journal article

C2 - 31281882

VL - 5

SP - eaav8192

JO - SCI ADV

JF - SCI ADV

SN - 2375-2548

IS - 7

ER -