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Hippocampal gray matter volume in bilateral vestibular failure

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Hippocampal gray matter volume in bilateral vestibular failure. / Göttlich, Martin; Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Center for Clinical Trials Lübeck, University of Lübeck, Lübeck., Department; Sprenger, Andreas; Wojak, Jann F; Münte, Thomas F; Krämer, Ulrike M; Helmchen, Christoph.

In: HUM BRAIN MAPP, Vol. 37, No. 5, 05.2016, p. 1998-2006.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Göttlich, M, Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Center for Clinical Trials Lübeck, University of Lübeck, Lübeck., D, Sprenger, A, Wojak, JF, Münte, TF, Krämer, UM & Helmchen, C 2016, 'Hippocampal gray matter volume in bilateral vestibular failure', HUM BRAIN MAPP, vol. 37, no. 5, pp. 1998-2006. https://doi.org/10.1002/hbm.23152

APA

Göttlich, M., Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Center for Clinical Trials Lübeck, University of Lübeck, Lübeck., D., Sprenger, A., Wojak, J. F., Münte, T. F., Krämer, U. M., & Helmchen, C. (2016). Hippocampal gray matter volume in bilateral vestibular failure. HUM BRAIN MAPP, 37(5), 1998-2006. https://doi.org/10.1002/hbm.23152

Vancouver

Göttlich M, Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Center for Clinical Trials Lübeck, University of Lübeck, Lübeck. D, Sprenger A, Wojak JF, Münte TF, Krämer UM et al. Hippocampal gray matter volume in bilateral vestibular failure. HUM BRAIN MAPP. 2016 May;37(5):1998-2006. https://doi.org/10.1002/hbm.23152

Bibtex

@article{8b2b2c660e144d3ca79a871f68983cc4,
title = "Hippocampal gray matter volume in bilateral vestibular failure",
abstract = "Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF. Although the two groups did not generally differ in their hippocampal GMV, a reduction of GMV in the bilateral hippocampal CA3 region was significantly correlated with increased vestibulopathy-related clinical impairment. We propose that GMV reduction in the hippocampus of BVF patients is related to the severity of vestibular-induced disability which is in line with combined hippocampal atrophy and disorders of spatial navigation in complete vestibular deafferentation due to bilateral nerve section. Clinically, however, the most frequent etiologies of BVF cause incomplete lesions. Accordingly, hippocampus atrophy and deficits in spatial navigation occur possibly less frequently than previously suspected. Hum Brain Mapp 37:1998-2006, 2016. {\textcopyright} 2016 Wiley Periodicals, Inc.",
keywords = "Aged, Atrophy/pathology, Bilateral Vestibulopathy/diagnostic imaging, Case-Control Studies, Electroencephalography, Evoked Potentials/physiology, Female, Gray Matter/diagnostic imaging, Hippocampus/pathology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reflex, Vestibulo-Ocular/physiology, Regression Analysis, Severity of Illness Index, Surveys and Questionnaires",
author = "Martin G{\"o}ttlich and {Medical Biometry and Statistics, University of L{\"u}beck, University Medical Center Schleswig-Holstein, Campus L{\"u}beck, Center for Clinical Trials L{\"u}beck, University of L{\"u}beck, L{\"u}beck.}, Department and Andreas Sprenger and Wojak, {Jann F} and M{\"u}nte, {Thomas F} and Kr{\"a}mer, {Ulrike M} and Christoph Helmchen",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2016",
month = may,
doi = "10.1002/hbm.23152",
language = "English",
volume = "37",
pages = "1998--2006",
journal = "HUM BRAIN MAPP",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Hippocampal gray matter volume in bilateral vestibular failure

AU - Göttlich, Martin

AU - Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Center for Clinical Trials Lübeck, University of Lübeck, Lübeck., Department

AU - Sprenger, Andreas

AU - Wojak, Jann F

AU - Münte, Thomas F

AU - Krämer, Ulrike M

AU - Helmchen, Christoph

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2016/5

Y1 - 2016/5

N2 - Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF. Although the two groups did not generally differ in their hippocampal GMV, a reduction of GMV in the bilateral hippocampal CA3 region was significantly correlated with increased vestibulopathy-related clinical impairment. We propose that GMV reduction in the hippocampus of BVF patients is related to the severity of vestibular-induced disability which is in line with combined hippocampal atrophy and disorders of spatial navigation in complete vestibular deafferentation due to bilateral nerve section. Clinically, however, the most frequent etiologies of BVF cause incomplete lesions. Accordingly, hippocampus atrophy and deficits in spatial navigation occur possibly less frequently than previously suspected. Hum Brain Mapp 37:1998-2006, 2016. © 2016 Wiley Periodicals, Inc.

AB - Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF. Although the two groups did not generally differ in their hippocampal GMV, a reduction of GMV in the bilateral hippocampal CA3 region was significantly correlated with increased vestibulopathy-related clinical impairment. We propose that GMV reduction in the hippocampus of BVF patients is related to the severity of vestibular-induced disability which is in line with combined hippocampal atrophy and disorders of spatial navigation in complete vestibular deafferentation due to bilateral nerve section. Clinically, however, the most frequent etiologies of BVF cause incomplete lesions. Accordingly, hippocampus atrophy and deficits in spatial navigation occur possibly less frequently than previously suspected. Hum Brain Mapp 37:1998-2006, 2016. © 2016 Wiley Periodicals, Inc.

KW - Aged

KW - Atrophy/pathology

KW - Bilateral Vestibulopathy/diagnostic imaging

KW - Case-Control Studies

KW - Electroencephalography

KW - Evoked Potentials/physiology

KW - Female

KW - Gray Matter/diagnostic imaging

KW - Hippocampus/pathology

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Reflex, Vestibulo-Ocular/physiology

KW - Regression Analysis

KW - Severity of Illness Index

KW - Surveys and Questionnaires

U2 - 10.1002/hbm.23152

DO - 10.1002/hbm.23152

M3 - SCORING: Journal article

C2 - 26918638

VL - 37

SP - 1998

EP - 2006

JO - HUM BRAIN MAPP

JF - HUM BRAIN MAPP

SN - 1065-9471

IS - 5

ER -