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High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia

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High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia. / Muijsers, Hella E C; Westermann, Dirk; Birukov, Anna; van der Heijden, Olivier W H; Drost, José T; Kräker, Kristin; Haase, Nadine; Müller, Dominik N; Herse, Florian; Maas, Angela H E M; Dechend, Ralf; Zeller, Tanja; Roeleveld, Nel.

In: J HYPERTENS, Vol. 38, No. 10, 10.2020, p. 1948-1954.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Muijsers, HEC, Westermann, D, Birukov, A, van der Heijden, OWH, Drost, JT, Kräker, K, Haase, N, Müller, DN, Herse, F, Maas, AHEM, Dechend, R, Zeller, T & Roeleveld, N 2020, 'High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia', J HYPERTENS, vol. 38, no. 10, pp. 1948-1954. https://doi.org/10.1097/HJH.0000000000002497

APA

Muijsers, H. E. C., Westermann, D., Birukov, A., van der Heijden, O. W. H., Drost, J. T., Kräker, K., Haase, N., Müller, D. N., Herse, F., Maas, A. H. E. M., Dechend, R., Zeller, T., & Roeleveld, N. (2020). High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia. J HYPERTENS, 38(10), 1948-1954. https://doi.org/10.1097/HJH.0000000000002497

Vancouver

Muijsers HEC, Westermann D, Birukov A, van der Heijden OWH, Drost JT, Kräker K et al. High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia. J HYPERTENS. 2020 Oct;38(10):1948-1954. https://doi.org/10.1097/HJH.0000000000002497

Bibtex

@article{0bd56a63ded34445963b3c1cc6c7319f,
title = "High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia",
abstract = "OBJECTIVE: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. We investigated whether high-sensitivity cardiac troponin I (hs-cTnI) levels are associated with a history of early-onset preeclampsia, and with hypertension in these high-risk women.METHODS: Approximately 9-10 years after pregnancy, hs-cTnI levels were measured for 339 women of the Preeclampsia Risk Evaluation in FEMales cohort, consisting of 177 women with a history of early-onset preeclampsia and 162 women with a previous uncomplicated index pregnancy. Associations were analyzed using several statistical tests and linear regression analysis.RESULTS: The median hs-cTnI levels (IQR) were 2.50 ng/l (2.30) in women with a history of early-onset preeclampsia and 2.35 ng/l (2.50) in women without a history of preeclampsia, P = 0.53. Among women with a history of early-onset preeclampsia, the hs-cTnI levels were higher in women who were hypertensive compared with their normotensive counterparts (medians 2.60 versus 2.30; P = 0.03). In addition, blood pressure levels increased with increasing hs-cTnI levels.CONCLUSION: We did not find a difference in hs-cTnI levels between women with and without a history of early-onset preeclampsia. Nonetheless, hs-cTnI levels were statistically significantly higher in current hypertensive women with a history of preeclampsia compared with their normotensive counterparts. Therefore, hs-cTnI levels might improve risk prediction for women at the highest risk of cardiovascular disease.",
keywords = "Blood Pressure, Cohort Studies, Female, Humans, Hypertension/epidemiology, Pre-Eclampsia/blood, Pregnancy, Risk Factors, Troponin I/blood",
author = "Muijsers, {Hella E C} and Dirk Westermann and Anna Birukov and {van der Heijden}, {Olivier W H} and Drost, {Jos{\'e} T} and Kristin Kr{\"a}ker and Nadine Haase and M{\"u}ller, {Dominik N} and Florian Herse and Maas, {Angela H E M} and Ralf Dechend and Tanja Zeller and Nel Roeleveld",
year = "2020",
month = oct,
doi = "10.1097/HJH.0000000000002497",
language = "English",
volume = "38",
pages = "1948--1954",
journal = "J HYPERTENS",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia

AU - Muijsers, Hella E C

AU - Westermann, Dirk

AU - Birukov, Anna

AU - van der Heijden, Olivier W H

AU - Drost, José T

AU - Kräker, Kristin

AU - Haase, Nadine

AU - Müller, Dominik N

AU - Herse, Florian

AU - Maas, Angela H E M

AU - Dechend, Ralf

AU - Zeller, Tanja

AU - Roeleveld, Nel

PY - 2020/10

Y1 - 2020/10

N2 - OBJECTIVE: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. We investigated whether high-sensitivity cardiac troponin I (hs-cTnI) levels are associated with a history of early-onset preeclampsia, and with hypertension in these high-risk women.METHODS: Approximately 9-10 years after pregnancy, hs-cTnI levels were measured for 339 women of the Preeclampsia Risk Evaluation in FEMales cohort, consisting of 177 women with a history of early-onset preeclampsia and 162 women with a previous uncomplicated index pregnancy. Associations were analyzed using several statistical tests and linear regression analysis.RESULTS: The median hs-cTnI levels (IQR) were 2.50 ng/l (2.30) in women with a history of early-onset preeclampsia and 2.35 ng/l (2.50) in women without a history of preeclampsia, P = 0.53. Among women with a history of early-onset preeclampsia, the hs-cTnI levels were higher in women who were hypertensive compared with their normotensive counterparts (medians 2.60 versus 2.30; P = 0.03). In addition, blood pressure levels increased with increasing hs-cTnI levels.CONCLUSION: We did not find a difference in hs-cTnI levels between women with and without a history of early-onset preeclampsia. Nonetheless, hs-cTnI levels were statistically significantly higher in current hypertensive women with a history of preeclampsia compared with their normotensive counterparts. Therefore, hs-cTnI levels might improve risk prediction for women at the highest risk of cardiovascular disease.

AB - OBJECTIVE: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. We investigated whether high-sensitivity cardiac troponin I (hs-cTnI) levels are associated with a history of early-onset preeclampsia, and with hypertension in these high-risk women.METHODS: Approximately 9-10 years after pregnancy, hs-cTnI levels were measured for 339 women of the Preeclampsia Risk Evaluation in FEMales cohort, consisting of 177 women with a history of early-onset preeclampsia and 162 women with a previous uncomplicated index pregnancy. Associations were analyzed using several statistical tests and linear regression analysis.RESULTS: The median hs-cTnI levels (IQR) were 2.50 ng/l (2.30) in women with a history of early-onset preeclampsia and 2.35 ng/l (2.50) in women without a history of preeclampsia, P = 0.53. Among women with a history of early-onset preeclampsia, the hs-cTnI levels were higher in women who were hypertensive compared with their normotensive counterparts (medians 2.60 versus 2.30; P = 0.03). In addition, blood pressure levels increased with increasing hs-cTnI levels.CONCLUSION: We did not find a difference in hs-cTnI levels between women with and without a history of early-onset preeclampsia. Nonetheless, hs-cTnI levels were statistically significantly higher in current hypertensive women with a history of preeclampsia compared with their normotensive counterparts. Therefore, hs-cTnI levels might improve risk prediction for women at the highest risk of cardiovascular disease.

KW - Blood Pressure

KW - Cohort Studies

KW - Female

KW - Humans

KW - Hypertension/epidemiology

KW - Pre-Eclampsia/blood

KW - Pregnancy

KW - Risk Factors

KW - Troponin I/blood

U2 - 10.1097/HJH.0000000000002497

DO - 10.1097/HJH.0000000000002497

M3 - SCORING: Journal article

C2 - 32890270

VL - 38

SP - 1948

EP - 1954

JO - J HYPERTENS

JF - J HYPERTENS

SN - 0263-6352

IS - 10

ER -