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High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study

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High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study. / Tynkkynen, Juho; Hernesniemi, Jussi A; Laatikainen, Tiina; Havulinna, Aki S; Salo, Perttu; Blankenberg, Stefan; Zeller, Tanja; Salomaa, Veikko.

In: J NEUROL, Vol. 264, No. 3, 03.2017, p. 503-511.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tynkkynen, J, Hernesniemi, JA, Laatikainen, T, Havulinna, AS, Salo, P, Blankenberg, S, Zeller, T & Salomaa, V 2017, 'High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study', J NEUROL, vol. 264, no. 3, pp. 503-511. https://doi.org/10.1007/s00415-016-8378-7

APA

Tynkkynen, J., Hernesniemi, J. A., Laatikainen, T., Havulinna, A. S., Salo, P., Blankenberg, S., Zeller, T., & Salomaa, V. (2017). High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study. J NEUROL, 264(3), 503-511. https://doi.org/10.1007/s00415-016-8378-7

Vancouver

Tynkkynen J, Hernesniemi JA, Laatikainen T, Havulinna AS, Salo P, Blankenberg S et al. High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study. J NEUROL. 2017 Mar;264(3):503-511. https://doi.org/10.1007/s00415-016-8378-7

Bibtex

@article{5b4645ab027e452c969351b6ef7af68a,
title = "High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study",
abstract = "Cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to associate with incident dementia. The purpose of our study was to examine whether high-sensitivity cardiac troponin I (hs-TnI) and NT-proBNP are associated with incident dementia and Alzheimer's disease (AD) independently of each other. Our study was a part of the national population-based health examination survey, FINRISK 1997, with a total sample of 7114 subjects, including 407 incident dementia cases and 319 AD cases during the follow-up time of 18 years. Using multivariate Cox regression analyses, we calculated the hazard ratios (HR) for hs-TnI and NT-proBNP. Analyses were adjusted for the previously known dementia/AD risk factors, including the apoE genotype. NT-proBNP was independently associated with incident dementia (HR 1.32, 95% CI 1.17-1.49) and AD (HR 1.30, 95% CI 1.13-1.5). Hs-TnI was also associated with incident dementia (HR 1.12, 95% CI 1.02-1.23), but not independent of NT-proBNP (HR 1.10, 95% CI 0.99-1.21). Hs-TnI was not associated with incident AD. The results remained similar in cause-specific Cox regression models and among subjects over 40 years of age. NT-proBNP and hs-TnI improved the reclassification of dementia risk in 10 years follow-up, and hs-TNI also in 18 years of follow-up. Neither hs-TnI nor NT-proBNP was able to outperform each other in risk reclassification of dementia. Both cardiovascular biomarkers, NT-proBNP and hs-TnI, were associated with incident dementia independently of traditional dementia risk factors including the apoE genotype. NT-proBNP was also associated with AD. Both markers offered a better dementia risk reclassification compared with traditional risk factors.",
keywords = "Adult, Aged, Apolipoproteins E/genetics, Biomarkers/blood, Blood Pressure, Cholesterol/blood, Dementia/blood, Finland/epidemiology, Follow-Up Studies, Humans, Middle Aged, Multivariate Analysis, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Proportional Hazards Models, Risk Factors, Surveys and Questionnaires, Troponin I/blood",
author = "Juho Tynkkynen and Hernesniemi, {Jussi A} and Tiina Laatikainen and Havulinna, {Aki S} and Perttu Salo and Stefan Blankenberg and Tanja Zeller and Veikko Salomaa",
year = "2017",
month = mar,
doi = "10.1007/s00415-016-8378-7",
language = "English",
volume = "264",
pages = "503--511",
journal = "J NEUROL",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study

AU - Tynkkynen, Juho

AU - Hernesniemi, Jussi A

AU - Laatikainen, Tiina

AU - Havulinna, Aki S

AU - Salo, Perttu

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Salomaa, Veikko

PY - 2017/3

Y1 - 2017/3

N2 - Cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to associate with incident dementia. The purpose of our study was to examine whether high-sensitivity cardiac troponin I (hs-TnI) and NT-proBNP are associated with incident dementia and Alzheimer's disease (AD) independently of each other. Our study was a part of the national population-based health examination survey, FINRISK 1997, with a total sample of 7114 subjects, including 407 incident dementia cases and 319 AD cases during the follow-up time of 18 years. Using multivariate Cox regression analyses, we calculated the hazard ratios (HR) for hs-TnI and NT-proBNP. Analyses were adjusted for the previously known dementia/AD risk factors, including the apoE genotype. NT-proBNP was independently associated with incident dementia (HR 1.32, 95% CI 1.17-1.49) and AD (HR 1.30, 95% CI 1.13-1.5). Hs-TnI was also associated with incident dementia (HR 1.12, 95% CI 1.02-1.23), but not independent of NT-proBNP (HR 1.10, 95% CI 0.99-1.21). Hs-TnI was not associated with incident AD. The results remained similar in cause-specific Cox regression models and among subjects over 40 years of age. NT-proBNP and hs-TnI improved the reclassification of dementia risk in 10 years follow-up, and hs-TNI also in 18 years of follow-up. Neither hs-TnI nor NT-proBNP was able to outperform each other in risk reclassification of dementia. Both cardiovascular biomarkers, NT-proBNP and hs-TnI, were associated with incident dementia independently of traditional dementia risk factors including the apoE genotype. NT-proBNP was also associated with AD. Both markers offered a better dementia risk reclassification compared with traditional risk factors.

AB - Cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to associate with incident dementia. The purpose of our study was to examine whether high-sensitivity cardiac troponin I (hs-TnI) and NT-proBNP are associated with incident dementia and Alzheimer's disease (AD) independently of each other. Our study was a part of the national population-based health examination survey, FINRISK 1997, with a total sample of 7114 subjects, including 407 incident dementia cases and 319 AD cases during the follow-up time of 18 years. Using multivariate Cox regression analyses, we calculated the hazard ratios (HR) for hs-TnI and NT-proBNP. Analyses were adjusted for the previously known dementia/AD risk factors, including the apoE genotype. NT-proBNP was independently associated with incident dementia (HR 1.32, 95% CI 1.17-1.49) and AD (HR 1.30, 95% CI 1.13-1.5). Hs-TnI was also associated with incident dementia (HR 1.12, 95% CI 1.02-1.23), but not independent of NT-proBNP (HR 1.10, 95% CI 0.99-1.21). Hs-TnI was not associated with incident AD. The results remained similar in cause-specific Cox regression models and among subjects over 40 years of age. NT-proBNP and hs-TnI improved the reclassification of dementia risk in 10 years follow-up, and hs-TNI also in 18 years of follow-up. Neither hs-TnI nor NT-proBNP was able to outperform each other in risk reclassification of dementia. Both cardiovascular biomarkers, NT-proBNP and hs-TnI, were associated with incident dementia independently of traditional dementia risk factors including the apoE genotype. NT-proBNP was also associated with AD. Both markers offered a better dementia risk reclassification compared with traditional risk factors.

KW - Adult

KW - Aged

KW - Apolipoproteins E/genetics

KW - Biomarkers/blood

KW - Blood Pressure

KW - Cholesterol/blood

KW - Dementia/blood

KW - Finland/epidemiology

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Multivariate Analysis

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Proportional Hazards Models

KW - Risk Factors

KW - Surveys and Questionnaires

KW - Troponin I/blood

U2 - 10.1007/s00415-016-8378-7

DO - 10.1007/s00415-016-8378-7

M3 - SCORING: Journal article

C2 - 28039523

VL - 264

SP - 503

EP - 511

JO - J NEUROL

JF - J NEUROL

SN - 0340-5354

IS - 3

ER -