High-risk donors: extending our criteria in times of organ shortage

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High-risk donors: extending our criteria in times of organ shortage. / Bernhardt, Alexander M; Reichenspurner, Hermann.

In: CURR OPIN ORGAN TRAN, Vol. 19, No. 5, 10.2014, p. 494-499.

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@article{f5fbe036b8ae43639ec511c42fb3f447,
title = "High-risk donors: extending our criteria in times of organ shortage",
abstract = "PURPOSE OF REVIEW: Increasing waiting lists and declining transplant numbers due to organ shortage are a global problem that needs a multimodal approach to overcome this situation. Extending the criteria for transplantation may be one part of the solution.RECENT FINDINGS: There are political efforts to increase the donor rate and change the listing criteria and the allocation process. Recently, the cardiac allocation score was introduced enhancing the factor urgency to the allocation process. Marginal donor organs can be accepted using ex-vivo perfusion strategies. Experimental approaches, such as donation after circulatory death and xenotransplantation, need to be further developed to be applied to humans and increase the pool of available transplant organs.SUMMARY: Organ shortage needs new approaches to overcome the discrepancy between the number of patients on the wait list and performed heart transplantations, reduce wait list mortality and improve long-term outcomes after transplantation.",
keywords = "Animals, Heart Transplantation, Humans, Risk Factors, Tissue Donors/supply & distribution, Tissue and Organ Procurement/statistics & numerical data, Transplantation, Heterologous, Waiting Lists",
author = "Bernhardt, {Alexander M} and Hermann Reichenspurner",
year = "2014",
month = oct,
doi = "10.1097/MOT.0000000000000118",
language = "English",
volume = "19",
pages = "494--499",
journal = "CURR OPIN ORGAN TRAN",
issn = "1087-2418",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - High-risk donors: extending our criteria in times of organ shortage

AU - Bernhardt, Alexander M

AU - Reichenspurner, Hermann

PY - 2014/10

Y1 - 2014/10

N2 - PURPOSE OF REVIEW: Increasing waiting lists and declining transplant numbers due to organ shortage are a global problem that needs a multimodal approach to overcome this situation. Extending the criteria for transplantation may be one part of the solution.RECENT FINDINGS: There are political efforts to increase the donor rate and change the listing criteria and the allocation process. Recently, the cardiac allocation score was introduced enhancing the factor urgency to the allocation process. Marginal donor organs can be accepted using ex-vivo perfusion strategies. Experimental approaches, such as donation after circulatory death and xenotransplantation, need to be further developed to be applied to humans and increase the pool of available transplant organs.SUMMARY: Organ shortage needs new approaches to overcome the discrepancy between the number of patients on the wait list and performed heart transplantations, reduce wait list mortality and improve long-term outcomes after transplantation.

AB - PURPOSE OF REVIEW: Increasing waiting lists and declining transplant numbers due to organ shortage are a global problem that needs a multimodal approach to overcome this situation. Extending the criteria for transplantation may be one part of the solution.RECENT FINDINGS: There are political efforts to increase the donor rate and change the listing criteria and the allocation process. Recently, the cardiac allocation score was introduced enhancing the factor urgency to the allocation process. Marginal donor organs can be accepted using ex-vivo perfusion strategies. Experimental approaches, such as donation after circulatory death and xenotransplantation, need to be further developed to be applied to humans and increase the pool of available transplant organs.SUMMARY: Organ shortage needs new approaches to overcome the discrepancy between the number of patients on the wait list and performed heart transplantations, reduce wait list mortality and improve long-term outcomes after transplantation.

KW - Animals

KW - Heart Transplantation

KW - Humans

KW - Risk Factors

KW - Tissue Donors/supply & distribution

KW - Tissue and Organ Procurement/statistics & numerical data

KW - Transplantation, Heterologous

KW - Waiting Lists

U2 - 10.1097/MOT.0000000000000118

DO - 10.1097/MOT.0000000000000118

M3 - SCORING: Review article

C2 - 25160699

VL - 19

SP - 494

EP - 499

JO - CURR OPIN ORGAN TRAN

JF - CURR OPIN ORGAN TRAN

SN - 1087-2418

IS - 5

ER -