High-level βIII-tubulin overexpression occurs in most head and neck cancers but is unrelated to clinical outcome
Standard
High-level βIII-tubulin overexpression occurs in most head and neck cancers but is unrelated to clinical outcome. / Nienstedt, Julie C; Gröbe, Alexander; Clauditz, Till; Simon, Ronald; Muenscher, Adrian; Knecht, Rainald; Sauter, Guido; Moebius, Christoph; Blessmann, Marco; Heiland, Max; Pflug, Christina.
In: J ORAL PATHOL MED, Vol. 46, No. 10, 11.2017, p. 986-990.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - High-level βIII-tubulin overexpression occurs in most head and neck cancers but is unrelated to clinical outcome
AU - Nienstedt, Julie C
AU - Gröbe, Alexander
AU - Clauditz, Till
AU - Simon, Ronald
AU - Muenscher, Adrian
AU - Knecht, Rainald
AU - Sauter, Guido
AU - Moebius, Christoph
AU - Blessmann, Marco
AU - Heiland, Max
AU - Pflug, Christina
N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2017/11
Y1 - 2017/11
N2 - BACKGROUND: βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential high importance of a prognostic biomarker in these cancers, this study aimed to investigate the clinical relevance of immunohistochemical TUBB3 expression in HNSCC.METHODS: Tissue microarray (TMA) sections containing samples from 667 cancers of oral cavity, oro- and hypopharynx, and larynx for which follow-up data were available were analyzed for TUBB3 expression by immunohistochemistry.RESULTS: Over 90% of our analyzed cancers showed unequivocal cytoplasmic TUBB3 expression. Staining was considered weak in 69 (15.5%), moderate in 149 (33.5%), and strong in 188 (42.2%) of cancers. The frequent TUBB3 overexpression showed no significant correlation with pathological grading, tumor stage, nodal status, or surgical margin and had no impact on patient outcomes.CONCLUSION: Despite lacking prognostic utility in HNSCC, the remarkable high prevalence of TUBB3 expression in HNSCC emphasizes its putative relevance as a target for future drugs targeting TUBB3.
AB - BACKGROUND: βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential high importance of a prognostic biomarker in these cancers, this study aimed to investigate the clinical relevance of immunohistochemical TUBB3 expression in HNSCC.METHODS: Tissue microarray (TMA) sections containing samples from 667 cancers of oral cavity, oro- and hypopharynx, and larynx for which follow-up data were available were analyzed for TUBB3 expression by immunohistochemistry.RESULTS: Over 90% of our analyzed cancers showed unequivocal cytoplasmic TUBB3 expression. Staining was considered weak in 69 (15.5%), moderate in 149 (33.5%), and strong in 188 (42.2%) of cancers. The frequent TUBB3 overexpression showed no significant correlation with pathological grading, tumor stage, nodal status, or surgical margin and had no impact on patient outcomes.CONCLUSION: Despite lacking prognostic utility in HNSCC, the remarkable high prevalence of TUBB3 expression in HNSCC emphasizes its putative relevance as a target for future drugs targeting TUBB3.
KW - Journal Article
U2 - 10.1111/jop.12607
DO - 10.1111/jop.12607
M3 - SCORING: Journal article
C2 - 28640948
VL - 46
SP - 986
EP - 990
JO - J ORAL PATHOL MED
JF - J ORAL PATHOL MED
SN - 0904-2512
IS - 10
ER -
