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Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2

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Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2. / Sato, Shoichiro; Heeley, Emma; Arima, Hisatomi; Delcourt, Candice; Hirakawa, Yoichiro; Pamidimukkala, Vijaya; Li, Zhendong; Tao, Qingling; Xu, Yuehong; Hennerici, Michael G; Robinson, Thompson; Tzourio, Christophe; Lindley, Richard I; Chalmers, John; Anderson, Craig S; INTERACT Investigators.

In: J NEUROL NEUROSUR PS, Vol. 86, No. 12, 12.2015, p. 1319-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sato, S, Heeley, E, Arima, H, Delcourt, C, Hirakawa, Y, Pamidimukkala, V, Li, Z, Tao, Q, Xu, Y, Hennerici, MG, Robinson, T, Tzourio, C, Lindley, RI, Chalmers, J, Anderson, CS & INTERACT Investigators 2015, 'Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2', J NEUROL NEUROSUR PS, vol. 86, no. 12, pp. 1319-23. https://doi.org/10.1136/jnnp-2014-309870

APA

Sato, S., Heeley, E., Arima, H., Delcourt, C., Hirakawa, Y., Pamidimukkala, V., Li, Z., Tao, Q., Xu, Y., Hennerici, M. G., Robinson, T., Tzourio, C., Lindley, R. I., Chalmers, J., Anderson, C. S., & INTERACT Investigators (2015). Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2. J NEUROL NEUROSUR PS, 86(12), 1319-23. https://doi.org/10.1136/jnnp-2014-309870

Vancouver

Sato S, Heeley E, Arima H, Delcourt C, Hirakawa Y, Pamidimukkala V et al. Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2. J NEUROL NEUROSUR PS. 2015 Dec;86(12):1319-23. https://doi.org/10.1136/jnnp-2014-309870

Bibtex

@article{0bbaa6103cd24d54bdf424fbffe34e4b,
title = "Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2",
abstract = "BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.",
keywords = "Aged, Blood Pressure, Cause of Death, Cerebral Hemorrhage, Disability Evaluation, Endpoint Determination, Female, Functional Laterality, Glasgow Coma Scale, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pilot Projects, Prognosis, Survivors, Treatment Outcome",
author = "Shoichiro Sato and Emma Heeley and Hisatomi Arima and Candice Delcourt and Yoichiro Hirakawa and Vijaya Pamidimukkala and Zhendong Li and Qingling Tao and Yuehong Xu and Hennerici, {Michael G} and Thompson Robinson and Christophe Tzourio and Lindley, {Richard I} and John Chalmers and Anderson, {Craig S} and {INTERACT Investigators} and Michael Rosenkranz and Christoph Beck and G{\"o}tz Thomalla and Bastian Cheng",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",
year = "2015",
month = dec,
doi = "10.1136/jnnp-2014-309870",
language = "English",
volume = "86",
pages = "1319--23",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2

AU - Sato, Shoichiro

AU - Heeley, Emma

AU - Arima, Hisatomi

AU - Delcourt, Candice

AU - Hirakawa, Yoichiro

AU - Pamidimukkala, Vijaya

AU - Li, Zhendong

AU - Tao, Qingling

AU - Xu, Yuehong

AU - Hennerici, Michael G

AU - Robinson, Thompson

AU - Tzourio, Christophe

AU - Lindley, Richard I

AU - Chalmers, John

AU - Anderson, Craig S

AU - INTERACT Investigators

AU - Rosenkranz, Michael

AU - Beck, Christoph

AU - Thomalla, Götz

AU - Cheng, Bastian

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2015/12

Y1 - 2015/12

N2 - BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

AB - BACKGROUND AND PURPOSE: Controversy exists over the prognostic significance of the affected hemisphere in stroke. We aimed to determine the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcomes.METHODS: A subsidiary analysis of the INTERACT Pilot and INTERACT2 studies--randomised controlled trials of patients with spontaneous acute ICH with elevated systolic blood pressure (BP), randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Outcomes were the combined and separate end points of death and major disability (modified Rankin scale (mRS) scores of 3-6, 6 and 3-5, respectively) at 90 days.RESULTS: A total of 2708 patients had supratentorial/hemispheric ICH and information on mRS at 90 days. Patients with right hemispheric ICH (1327, 49%) had a higher risk of death at 90 days compared to those with left hemispheric ICH after adjustment for potential confounding variables (OR, 1.77 (95% CI 1.33 to 2.37)). There were no differences between patients with right and left hemispheric ICH regarding the combined end point of death or major disability or major disability in the multivariable-adjusted models (1.07 (0.89 to 1.29) and 0.85 (0.72 to 1.01), respectively).CONCLUSIONS: Right hemispheric lesion was associated with increased risk of death in patients with acute ICH. The laterality of the ICH does not appear to affect the level of disability in survivors.TRIAL REGISTRATION NUMBER: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

KW - Aged

KW - Blood Pressure

KW - Cause of Death

KW - Cerebral Hemorrhage

KW - Disability Evaluation

KW - Endpoint Determination

KW - Female

KW - Functional Laterality

KW - Glasgow Coma Scale

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Prognosis

KW - Survivors

KW - Treatment Outcome

U2 - 10.1136/jnnp-2014-309870

DO - 10.1136/jnnp-2014-309870

M3 - SCORING: Journal article

C2 - 25589782

VL - 86

SP - 1319

EP - 1323

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 12

ER -