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Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion

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Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion. / Broocks, Gabriel; Groffmann, Maximilian; Meyer, Lukas; Elsayed, Sarah; Kniep, Helge; Kemmling, Andre; van Horn, Noel; McDonough, Rosalie; Faizy, Tobias D; Bechstein, Matthias; Sporns, Peter; Rusche, Thilo; Schön, Gerhard; Nawabi, Jawed; Fiehler, Jens; Hanning, Uta.

In: J NEUROL, Vol. 269, No. 6, 06.2022, p. 3286-3294.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Broocks, G, Groffmann, M, Meyer, L, Elsayed, S, Kniep, H, Kemmling, A, van Horn, N, McDonough, R, Faizy, TD, Bechstein, M, Sporns, P, Rusche, T, Schön, G, Nawabi, J, Fiehler, J & Hanning, U 2022, 'Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion', J NEUROL, vol. 269, no. 6, pp. 3286-3294. https://doi.org/10.1007/s00415-021-10948-1

APA

Broocks, G., Groffmann, M., Meyer, L., Elsayed, S., Kniep, H., Kemmling, A., van Horn, N., McDonough, R., Faizy, T. D., Bechstein, M., Sporns, P., Rusche, T., Schön, G., Nawabi, J., Fiehler, J., & Hanning, U. (2022). Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion. J NEUROL, 269(6), 3286-3294. https://doi.org/10.1007/s00415-021-10948-1

Vancouver

Broocks G, Groffmann M, Meyer L, Elsayed S, Kniep H, Kemmling A et al. Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion. J NEUROL. 2022 Jun;269(6):3286-3294. https://doi.org/10.1007/s00415-021-10948-1

Bibtex

@article{f747c6b852c44c0fb026c146fcec29c7,
title = "Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion",
abstract = "PURPOSE: Evidence regarding the effect of mechanical thrombectomy (MT) of basilar artery occlusion (BAO) stroke is yet sparse. As successful recanalization has been suggested as major determinant of outcome, the early identification of modifiable factors associated with successful recanalization could be of importance to improve functional outcome. Hyperglycemia has been associated with enhanced thrombin generation and unfavorably altered clot features.OBJECTIVE: We hypothesized that serum baseline glucose is associated with likelihood of vessel recanalization mediated by collateral quality and clot burden in BAO stroke.METHODS: BAO stroke patients who received multimodal CT on admission were analyzed. The association of vessel recanalization defined using modified Thrombolysis in cerebral infarction scale (mTICI) scores 2b-3, and baseline imaging and clinical parameters were tested in logistic regression analyses. Collateral quality and clot burden were evaluated using the Basilar Artery on CT-Angiography (BATMAN) score.RESULTS: Out of 117 BAO patients, 91 patients (78%) underwent MT. In 70 patients (77%), successful recanalization could be achieved (mTICI 2b/3). In multivariable logistic regression analysis, only a higher BGL (aOR 0.97, 95% CI 0.96-0.99, p = 0.03) and higher BATMAN score (aOR 1.77, 95% CI 1.11-2.82, p = 0.02) were independently associated with vessel recanalization. Application of alteplase, or time from symptom onset-imaging revealed no independent association with recanalization status.CONCLUSION: Higher BGL was significantly associated with reduced likelihood for recanalization success besides BATMAN score as a measure of collateral quality and clot burden. BGL could be tested as a modifiable parameter to increase likelihood for recanalization in BAO stroke, aiming to improve functional outcome.",
author = "Gabriel Broocks and Maximilian Groffmann and Lukas Meyer and Sarah Elsayed and Helge Kniep and Andre Kemmling and {van Horn}, Noel and Rosalie McDonough and Faizy, {Tobias D} and Matthias Bechstein and Peter Sporns and Thilo Rusche and Gerhard Sch{\"o}n and Jawed Nawabi and Jens Fiehler and Uta Hanning",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = jun,
doi = "10.1007/s00415-021-10948-1",
language = "English",
volume = "269",
pages = "3286--3294",
journal = "J NEUROL",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion

AU - Broocks, Gabriel

AU - Groffmann, Maximilian

AU - Meyer, Lukas

AU - Elsayed, Sarah

AU - Kniep, Helge

AU - Kemmling, Andre

AU - van Horn, Noel

AU - McDonough, Rosalie

AU - Faizy, Tobias D

AU - Bechstein, Matthias

AU - Sporns, Peter

AU - Rusche, Thilo

AU - Schön, Gerhard

AU - Nawabi, Jawed

AU - Fiehler, Jens

AU - Hanning, Uta

N1 - © 2022. The Author(s).

PY - 2022/6

Y1 - 2022/6

N2 - PURPOSE: Evidence regarding the effect of mechanical thrombectomy (MT) of basilar artery occlusion (BAO) stroke is yet sparse. As successful recanalization has been suggested as major determinant of outcome, the early identification of modifiable factors associated with successful recanalization could be of importance to improve functional outcome. Hyperglycemia has been associated with enhanced thrombin generation and unfavorably altered clot features.OBJECTIVE: We hypothesized that serum baseline glucose is associated with likelihood of vessel recanalization mediated by collateral quality and clot burden in BAO stroke.METHODS: BAO stroke patients who received multimodal CT on admission were analyzed. The association of vessel recanalization defined using modified Thrombolysis in cerebral infarction scale (mTICI) scores 2b-3, and baseline imaging and clinical parameters were tested in logistic regression analyses. Collateral quality and clot burden were evaluated using the Basilar Artery on CT-Angiography (BATMAN) score.RESULTS: Out of 117 BAO patients, 91 patients (78%) underwent MT. In 70 patients (77%), successful recanalization could be achieved (mTICI 2b/3). In multivariable logistic regression analysis, only a higher BGL (aOR 0.97, 95% CI 0.96-0.99, p = 0.03) and higher BATMAN score (aOR 1.77, 95% CI 1.11-2.82, p = 0.02) were independently associated with vessel recanalization. Application of alteplase, or time from symptom onset-imaging revealed no independent association with recanalization status.CONCLUSION: Higher BGL was significantly associated with reduced likelihood for recanalization success besides BATMAN score as a measure of collateral quality and clot burden. BGL could be tested as a modifiable parameter to increase likelihood for recanalization in BAO stroke, aiming to improve functional outcome.

AB - PURPOSE: Evidence regarding the effect of mechanical thrombectomy (MT) of basilar artery occlusion (BAO) stroke is yet sparse. As successful recanalization has been suggested as major determinant of outcome, the early identification of modifiable factors associated with successful recanalization could be of importance to improve functional outcome. Hyperglycemia has been associated with enhanced thrombin generation and unfavorably altered clot features.OBJECTIVE: We hypothesized that serum baseline glucose is associated with likelihood of vessel recanalization mediated by collateral quality and clot burden in BAO stroke.METHODS: BAO stroke patients who received multimodal CT on admission were analyzed. The association of vessel recanalization defined using modified Thrombolysis in cerebral infarction scale (mTICI) scores 2b-3, and baseline imaging and clinical parameters were tested in logistic regression analyses. Collateral quality and clot burden were evaluated using the Basilar Artery on CT-Angiography (BATMAN) score.RESULTS: Out of 117 BAO patients, 91 patients (78%) underwent MT. In 70 patients (77%), successful recanalization could be achieved (mTICI 2b/3). In multivariable logistic regression analysis, only a higher BGL (aOR 0.97, 95% CI 0.96-0.99, p = 0.03) and higher BATMAN score (aOR 1.77, 95% CI 1.11-2.82, p = 0.02) were independently associated with vessel recanalization. Application of alteplase, or time from symptom onset-imaging revealed no independent association with recanalization status.CONCLUSION: Higher BGL was significantly associated with reduced likelihood for recanalization success besides BATMAN score as a measure of collateral quality and clot burden. BGL could be tested as a modifiable parameter to increase likelihood for recanalization in BAO stroke, aiming to improve functional outcome.

U2 - 10.1007/s00415-021-10948-1

DO - 10.1007/s00415-021-10948-1

M3 - SCORING: Journal article

C2 - 34984515

VL - 269

SP - 3286

EP - 3294

JO - J NEUROL

JF - J NEUROL

SN - 0340-5354

IS - 6

ER -